Rat MRP2 Vesicles, ABC transporter vesicles

• Cat.No.: MRP2 Vesicles-02R
• Product Overview: Rat MRP2 Vesicles are insect derived purified plasma membranes with inserted MRP2 transport protein (multidrug resistance-associated protein, ABCC2). Our Rat MRP2 Vesicles can be used to evaluate test compounds and drug interactions with MRP2 in in vitro assays. MRP2 is an ATP-binding cassette (ABC) transporter that carries organic anions.

Specification

• Species: Rat
• Source: Insect Cells
• Description: Rat MRP2 Vesicles are part of a larger group of transporter vesicles known as ABC transporter vesicles. They are prepared from purified plasma membranes isolated from an insect cell system (Sf9 cells transfected with baculovirus) expressing MRP2. MRP2 is expressed in various organs, and is thought to play a role in excretion of various compounds from the kidney and liver, based on its localization on the canalicular plasma membrane of hepatocytes and brush border membrane of tubular epithelial cells.
• Form: Frozen
• Concept Behind ABC Transporter Vesicles: ABC transporter vesicles are easy-to-use, efficient reagents for early assessment of a drug candidate's substrate and drug interaction potential. While ABC transporters typically mediate the export of substrates out of cells, transporters expressed on these inside-out vesicles import substrates into the vesicles. It is therefore possible to quantitatively evaluate transport activity for your compound by determining the amount incorporated into the vesicles.
• Clear and Reliable Results: Prepared from Sf9 cells which have been engineered to over-express specific ABC transporters, these 'inside-out' vesicles provide high levels of transporter activity with low background, giving you a clear signal if your compound is a substrate or inhibitor of a specific efflux transporter.
• Applications: Use Rat MRP2 Vesicles to: Investigate the transporter interactions of your drug candidates Assess potential for transporter-mediated drug-drug interactions Obtain high quality results with a large signal to noise ratios
• Notes: For Research Use Only. Not for use in diagnostic procedures.
• Storage: Store at -80 centigrade.
• Shipping: Dry Ice

Gene Information

• Gene Name: Abcc2 ATP binding cassette subfamily C member 2 [ Rattus norvegicus (Norway rat) ]
• Official Symbol: ABCC2
• Synonyms: ABCC2; ATP-binding cassette, subfamily C (CFTR/MRP), member 2; canalicular multispecific organic anion transporter 1; canalicular multidrug resistance protein; multidrug resistance associated protein 2; multidrug resistance-associated protein 2; ATP-binding cassette sub-family C member 2; calicular multispecific organic anion transporter; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mrp2; Cmoat
• Gene ID: 25303
• mRNA Refseq: NM_012833
• Protein Refseq: NP_036965
• UniProt ID: Q63120