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ABHD11

  • Official Full Name

    abhydrolase domain containing 11

  • Overview

    This gene encodes a protein containing an alpha/beta hydrolase fold domain. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
  • Synonyms

    ABHD11; abhydrolase domain containing 11; WBSCR21, Williams Beuren syndrome chromosome region 21; abhydrolase domain-containing protein 11; PP1226; WBSCR21; Williams-Beuren syndrome chromosomal region 21 protein; Williams Beuren syndrome chromosome region 21;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His|SUMO
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ABHD11-072H Recombinant Human ABHD11 Protein, GST-Tagged Wheat Germ GST
Human ABHD11-9140HCL Recombinant Human ABHD11 293 Cell Lysate HEK293 N/A
Human ABHD11-826HF Recombinant Full Length Human ABHD11 Protein, GST-tagged In Vitro Cell Free System GST 315 amino acids
Mouse ABHD11-1747M Recombinant Mouse ABHD11 Protein (1-307 aa), His-tagged Yeast His 1-307 aa
Mouse Abhd11-1466M Recombinant Mouse Abhd11 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ABHD11-1062M Recombinant Mouse ABHD11 Protein (1-307 aa), His-SUMO-tagged E.coli His/SUMO 1-307 aa
Zebrafish ABHD11-1236Z Recombinant Zebrafish ABHD11 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ABHD11 Related Articles

ABHD11 involved in several pathways and played different roles in them. We selected most pathways ABHD11 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ABHD11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ABHD11 has several biochemical functions, for example, carboxylic ester hydrolase activity, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by ABHD11 itself. We selected most functions ABHD11 had, and list some proteins which have the same functions with ABHD11. You can find most of the proteins on our site.

Function Related Protein
carboxylic ester hydrolase activityLIPH;LYPLA2;Cel;Ces2e;ACOT9;ACOT10;PNPLA7;NCEH1B;NOTUM1A
molecular_functionNLRP9C;ARRDC3B;ELP5;TMX2A;LRRTM1;TMEM125;PRF1.6;GAS8;TC2N

ABHD11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABHD11 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABHD11.

Wiedl, T; Arni, S; et al. Activity-based proteomics: Identification of ABHD11 and ESD activities as potential biomarkers for human lung adenocarcinoma. JOURNAL OF PROTEOMICS 74:1884-1894(2011).
  • Q&As
  • Reviews

Q&As (10)

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What kind of disease is ABHD a biomarker? 02/26/2022

ABHD11 is a potential biomarker of lung adenocarcinoma, and is linked to breast cancer malignancy.

What is the influence of ABHD11 for 2-oxoglutarate in metabolic pathways? 01/09/2022

ABHD11 loss or inhibition drives a rapid increase in 2-OG levels by impairing lipoylation of the 2-OG dehydrogenase complex (OGDHc)—the rate limiting step for mitochondrial 2-OG metabolism.

What disease caused by the ABHD11 abnormal? 04/10/2021

ABHD11 is one of several genes deleted in Williams–Beuren syndrome, a developmental disorder associated with haploinsufficiency of multiple genes.

What fact suggest that ABHD11 was involved in the maintenance of embryonic stem cell identity? 02/21/2021

The results of bioinformatic analysis demonstrated that ABHD11 and ABHD10 were downregulated, while most other ABHD family genes, such as Abhd 1, 3, 5, 6, and 7 were upregulated in OCT4-negative cells.

What is the consequences if knockout ABHD11 gene? 02/03/2021

ABHD11 knockout disturbed GSK3β/β-Catenin and ERK signaling transduction; ABHD11 knockout led to the misexpression of key metabolic enzymes related to lipid synthesis, glycolysis, and amino acid metabolism.

What disease often use the ABHD11 as prognostic marker? 12/01/2020

The ABHD11 often as a prognostic marker of renal cancer.

Where does the ABHD11 protein express in human body? 01/06/2019

Kidney - Transmembrane transport (mainly)

What is the results if the ABHD11 overexpress in yeast? 08/11/2018

In yeast, the overexpression of ABHD11 or its yeast homolog causes a reduction in the levels of non-polar lipids.

List at least three cellular components of the ABHD11 protein? 01/27/2018

1. plasma membrane, 2. endosome, 3. mitochondrion

What results we got when a study conlcuded that qRT-PCR to show that the ABHD11-AS1 expression level was higher in ovarian cancer tissues than in normal ovarian tissue? 01/09/2018

This results suggested that the ABHD11 gene promote cancer cell proliferation, metastasis, and invasion, and inhibit cancer cell apoptosis.

Customer Reviews (4)

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Reviews
07/10/2022

    Great work on ELISA with recommended dilution !

    06/07/2022

      Excellent quality products!

      11/06/2021

        We are satisfied with the WB results of ABHD11 product.

        03/15/2021

          After-sales questions were answered in a timely manner. Good!

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