ABHD11
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Official Full Name
abhydrolase domain containing 11
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Overview
This gene encodes a protein containing an alpha/beta hydrolase fold domain. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. -
Synonyms
ABHD11; abhydrolase domain containing 11; WBSCR21, Williams Beuren syndrome chromosome region 21; abhydrolase domain-containing protein 11; PP1226; WBSCR21; Williams-Beuren syndrome chromosomal region 21 protein; Williams Beuren syndrome chromosome region 21;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- His|SUMO
- Myc
- DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | ABHD11-072H | Recombinant Human ABHD11 Protein, GST-Tagged | Wheat Germ | GST | ||
Human | ABHD11-9140HCL | Recombinant Human ABHD11 293 Cell Lysate | HEK293 | N/A | ||
Human | ABHD11-826HF | Recombinant Full Length Human ABHD11 Protein, GST-tagged | In Vitro Cell Free System | GST | 315 amino acids | |
Mouse | ABHD11-1747M | Recombinant Mouse ABHD11 Protein (1-307 aa), His-tagged | Yeast | His | 1-307 aa | |
Mouse | Abhd11-1466M | Recombinant Mouse Abhd11 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Mouse | ABHD11-1062M | Recombinant Mouse ABHD11 Protein (1-307 aa), His-SUMO-tagged | E.coli | His/SUMO | 1-307 aa | |
Zebrafish | ABHD11-1236Z | Recombinant Zebrafish ABHD11 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- ABHD11 Related Articles
ABHD11 involved in several pathways and played different roles in them. We selected most pathways ABHD11 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ABHD11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ABHD11 has several biochemical functions, for example, carboxylic ester hydrolase activity, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by ABHD11 itself. We selected most functions ABHD11 had, and list some proteins which have the same functions with ABHD11. You can find most of the proteins on our site.
Function | Related Protein |
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carboxylic ester hydrolase activity | LIPH;LYPLA2;Cel;Ces2e;ACOT9;ACOT10;PNPLA7;NCEH1B;NOTUM1A |
molecular_function | NLRP9C;ARRDC3B;ELP5;TMX2A;LRRTM1;TMEM125;PRF1.6;GAS8;TC2N |
ABHD11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABHD11 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABHD11.
- Q&As
- Reviews
Q&As (10)
Ask a questionABHD11 is a potential biomarker of lung adenocarcinoma, and is linked to breast cancer malignancy.
ABHD11 loss or inhibition drives a rapid increase in 2-OG levels by impairing lipoylation of the 2-OG dehydrogenase complex (OGDHc)—the rate limiting step for mitochondrial 2-OG metabolism.
ABHD11 is one of several genes deleted in Williams–Beuren syndrome, a developmental disorder associated with haploinsufficiency of multiple genes.
The results of bioinformatic analysis demonstrated that ABHD11 and ABHD10 were downregulated, while most other ABHD family genes, such as Abhd 1, 3, 5, 6, and 7 were upregulated in OCT4-negative cells.
ABHD11 knockout disturbed GSK3β/β-Catenin and ERK signaling transduction; ABHD11 knockout led to the misexpression of key metabolic enzymes related to lipid synthesis, glycolysis, and amino acid metabolism.
The ABHD11 often as a prognostic marker of renal cancer.
Kidney - Transmembrane transport (mainly)
In yeast, the overexpression of ABHD11 or its yeast homolog causes a reduction in the levels of non-polar lipids.
1. plasma membrane, 2. endosome, 3. mitochondrion
This results suggested that the ABHD11 gene promote cancer cell proliferation, metastasis, and invasion, and inhibit cancer cell apoptosis.
Customer Reviews (4)
Write a reviewGreat work on ELISA with recommended dilution !
Excellent quality products!
We are satisfied with the WB results of ABHD11 product.
After-sales questions were answered in a timely manner. Good!
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