abl2
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  • Official Full Name
  • v-abl Abelson murine leukemia viral oncogene homolog 2
  • Background
  • This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
  • Synonyms
  • ABL2; v-abl Abelson murine leukemia viral oncogene homolog 2; ABLL, v abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson related gene); Abelson tyrosine-protein kinase 2; Abelson related gene; ARG; tyrosine-protein kinase ARG; abelson-rel
Cat.#:ABL2-105HTag:His
Source (Host):InsectSpecies:Human
Product nameRecombinant Human ABL2 Protein, His-Tagged
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Cat.#:ABL2-106HTag:GST
Source (Host):Wheat Germ (in vitro)Species:Human
Product nameRecombinant Human ABL2 Protein, GST-Tagged
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Cat.#:ABL2-233HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ABL2, His-tagged
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Cat.#:ABL2-673HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ABL2, GST-tagged
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Cat.#:ABL2-9250HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ABL2, His-tagged
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Cat.#:Abl2-233MTag:His
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Abl2, His-tagged, Active
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Cat.#:ARG-3620MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse ARG, His-tagged
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Cat.#:ABL2-6578ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ABL2
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Cat.#:ABL2-9126HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ABL2 293 Cell Lysate
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Involved Pathway

Abl2 involved in several pathways and played different roles in them. We selected most pathways Abl2 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Viral myocarditis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Abl2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
RPS6KB1B; PIK3CA; CBLB; PIK3R5; CBL; NCK2; PAK2A; KRAS; PRKCBA; NCK2B
Ras signaling pathway
STK4; RAF1; KLK1B4; MAP2K1; CALM1; PLA2G12A; FGF4; RRAS; SOS1; RAPGEF5
Viral myocarditis
ITGAL; SGCB; EIF4G2; LAMA2; HLA-E; ACTG1; SGCD; HLA-DRB5; HLA-DQA2; HLA-DMB

Protein Function

Abl2 has several biochemical functions, for example, ATP binding, actin filament binding, actin monomer binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Abl2 itself. We selected most functions Abl2 had, and list some proteins which have the same functions with Abl2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein NLRP4B; KIF3A; DYRK1A; FARSA; DYRK4; CKMA; DNAHC8; DHX37; SGK3; PIK3R4
Function actin filament binding
Related Protein SCIN; AASS; TRIOBP; CORO1A; SHROOM4; ACTN2; PANX1; BLOC1S6; PLS1; CORO2B
Function actin monomer binding
Related Protein ABL1; TWF2; TMSB15B; PRKCE; NOS3; MYL4; LIMA1; PFN1; MYL2; TMSB4X
Function magnesium ion binding
Related Protein FARS2; MARK1; STK38L; PTENA; GLUL; ATP8A1; ATP11A; SERPINB1A; NT5C3B; PPA1B
Function manganese ion binding
Related Protein LAP3; PPM1AB; SLC11A2; GYLTL1B; GLUL; XPNPEP3; DYRK2; NUDT16; PAPOLA; PPM1BA
Function non-membrane spanning protein tyrosine kinase activity
Related Protein TNK2; TYK2; HCK; FYNB; JAK2B; SRMS; TNK2B; FES; TEC; BTK
Function protein binding
Related Protein LRR1; EIF4A2; FAM82A2; CXorf40A; OPA1; SOCS5; C19orf60; VDAC1; ARR3; ZNF385C
Function protein kinase activity
Related Protein MAPK8A; CAMK2B1; NLK2; NAT1; ERBB3A; NEK10; EPHB4A; RPS6KB1; RBM4.3; NTRK3A
Function protein tyrosine kinase activity
Related Protein JAK2; MATK; FYNB; CLK2; CLK4; NTRK2B; FGFR1; BAZ1B; PTK6B; MAP3K9
Function receptor binding
Related Protein FGF20A; HFE; IFNL3; HFE2; H2-Q10; ANGPTL1; TYROBP; RARRES2; NUDT19; WNT2BA

Interacting Protein

Abl2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Abl2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Abl2.
CRK; PLCG1; EGFR; NCK1

Abl2 Related Articles

Pershad, K; Pavlovic, JD; et al. Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display. PROTEIN ENGINEERING DESIGN & SELECTION 23:279-288(2010).
Liu, M; Oh, A; et al. Peptidylarginine deiminase (PAD) is a mouse cortical granule protein that plays a role in preimplantation embryonic development. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 3:-(2005).