Abl2
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Official Full Name
v-abl Abelson murine leukemia viral oncogene homolog 2
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Overview
This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. -
Synonyms
ABL2; v-abl Abelson murine leukemia viral oncogene homolog 2; ABLL, v abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson related gene); Abelson tyrosine-protein kinase 2; Abelson related gene; ARG; tyrosine-protein kinase ARG; abelson-rel;
- Recombinant Proteins
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- Human
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- Sf9 Insect Cell
- Wheat Germ
- GST
- His
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
Abl2 involved in several pathways and played different roles in them. We selected most pathways Abl2 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Viral myocarditis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Abl2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ErbB signaling pathway | ERBB4A;CDKN1BB;PRKCA;BTC;NRG2;BRAF;GRB2B;RPS6KB1;HRAS |
| Ras signaling pathway | RASA3;RAB5C;ETS1;SHC4;LOC608458;FLT4;GRIN1;NGFR;RALB |
| Viral myocarditis | BID;HLA-G;CASP8;HLA-DQA2;HLA-DRB4;HLA-DRB5;Casp3;HLA-DRB3;CYCS |
Abl2 has several biochemical functions, for example, ATP binding, actin filament binding, actin monomer binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Abl2 itself. We selected most functions Abl2 had, and list some proteins which have the same functions with Abl2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MYH13;MAP3K6;PAK4;TOP2A;DHX36;EGFRA;SLFNL1;YRK;PSMC3 |
| actin filament binding | ANXA8;SHROOM1;MYH10;TNNC1;SLC6A4;SHROOM3;MYO7A;SHROOM2;SMYHC2 |
| actin monomer binding | PKNOX2;MYL4;MTSS1;NOS3;MKL1;TMSB4X;TMSB10;COBLL1;COBL |
| magnesium ion binding | ENOPH1;FDXACB1;IDH3G;PINK1;PPM1AB;TSSK2;PPM1NB;ADSS;NT5C1A |
| manganese ion binding | FAM20C;B4GALT7;XPNPEP1;PPM1NB;PPM1A;PIM1;MTPAP;DYRK2;GYLTL1B |
| non-membrane spanning protein tyrosine kinase activity | PRKCD;ZAP70;JAK2B;BLK;TEC;FRK;FYNA;EIF2AK2;FYNB |
| protein binding | IFITM1;NONO;CLINT1;SH3BP4;FAM96B;DDX19B;RRP7A;ARHGAP26;NFASC |
| protein kinase activity | EPHA4B;ERBB3B;GC3;MAP2K4A;AURKC;RBM4.3;DYRK1AA;STK38A;BMPR2A |
| protein tyrosine kinase activity | MAP2K6;Fert2;DYRK3;LCK;JAK1;ALK;KDR;TTN;ERBB4 |
| receptor binding | POMC;NPPA;EPB49;NRG2A;CADM1B;NCK1;GLA;LHB;ACOT8 |
Abl2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Abl2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Abl2.
CRK; PLCG1; EGFR; NCK1
Research Area
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Q&As (8)
Ask a questionMagnesium, Manganese,Nucleotide, etc.
ABL2 localization in cytoplasm and cytoskeleton.
ABL2 involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35.
ABL2 has polyubiquitination and glycosylation modifications, etc.
Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis.
abl1 is the important paralog of abl2. abl2 plays an abl1-overlapping role in key processes linked to cell growth and survival.
Diseases associated with ABL2 include Leukemia and B-Lymphoblastic Leukemia/Lymphoma With Bcr-Abl1.
This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia.
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