| Description : |
This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
126.5 kDa |
| AA Sequence : |
MVLGTVLLPPNSYGRDQDTSLCCLC TEASESALPDLTDHFASCVEDGFEG DKTGGSSPEALHRPYGCDVEPQALN EAIRWSSKENLLGATESDPNLFVAL YDFVASGDNTLSITKGEKLRVLGYN QNGEWSEVRSKNGQGWVPSNYITPV NSLEKHSWYHGPVSRSAAEYLLSSL INGSFLVRESESSPGQLSISLRYEG RVYHYRINTTADGKVYVTAESRFST LAELVHHHSTVADGLVTTLHYPAPK CNKPTVYGVSPIHDKWEMERTDITM KHKLGGGQYGEVYVGVWKKYSLTVA VKTLKEDTMEVEEFLKEAAVMKEIK HPNLVQLLGVCTLEPPFYIVTEYMP YGNLLDYLRECNREEVTAVVLLYMA TQISSAMEYLEKKNFIHRDLAARNC LVGENHVVKVADFGLSRLMTGDTYT AHAGAKFPIKWTAPESLAYNTFSIK SDVWAFGVLLWEIATYGMSPYPGID LSQVYDLLEKGYRMEQPEGCPPKVY ELMRACWKWSPADRPSFAETHQAFE TMFHDSSISEEVAEELGRAASSSSV VPYLPRLPILPSKTRTLKKQVENKE NIEGAQDATENSASSLAPGFIRGAQ ASSGSPALPRKQRDKSPSSLLEDAK ETCFTRDRKGGFFSSFMKKRNAPTP PKRSSSFREMENQPHKKYELTGNFS SVASLQHADGFSFTPAQQEANLVPP KCYGGSFAQRNLCNDDGGGGGGSGT AGGGWSGITGFFTPRLIKKTLGLRA GKPTASDDTSKPFPRSNSTSSMSSG LPEQDRMAMTLPRNCQRSKLQLERT VSTSSQPEENVDRANDMLPKKSEES AAPSRERPKAKLLPRGATALPLRTP SGDLAITEKDPPGVGVAGVAAAPKG KEKNGGARLGMAGVPEDGEQPGWPS PAKAAPVLPTTHNHKVPVLISPTLK HTPADVQLIGTDSQGNKFKLLSEHQ VTSSGDKDRPRRVKPKCAPPPPPVM RLLQHPSICSDPTEEPTALTAGQST SETQEGGKKAALGAVPISGKAGRPV MPPPQVPLPTSSISPAKMANGTAGT KVALRKTKQAAEKISADKISKEALL ECADLLSSALTEPVPNSQLVDTGHQ LLDYCSGYVDCIPQTRNKFAFREAV SKLELSLQELQVSSAAAGVPGTNPV LNNLLSCVQEISDVVQRTRTRPLEQ KLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
