Active Recombinant Human ABL2, His-tagged

• Cat.No.: ABL2-233H
• Product Overview: Recombinant human ABL2 (38-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.

Specification

• Description: This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
• Source: Sf9 insect cells
• Species: Human
• Tag: His
• Form: Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
• Bio-activity: 1218 nmol/min/mg
• Molecular Mass: ~132 kDa
• AA Sequence: 38-end
• Purity: >70%
• Applications: Kinase Assay, Western Blot
• Stability: 1 yr at -70°C from date of shipment.
• Storage: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 ug/ul

Gene Information

• Gene Name: ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase [ Homo sapiens (human) ]
• Official Symbol: ABL2
• Synonyms: ABL2; v-abl Abelson murine leukemia viral oncogene homolog 2; Abelson murine leukemia viral (v-abl) oncogene homolog 2; OTTHUMP00000033140; OTTHUMP00000218106; abelson murine leukemia viral oncogene homolog 2; abelson-related gene protein; arg tyrosine kinase; tyrosine-protein kinase ABL2; tyrosine-protein kinase ARG; v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene); ARG; ABLL; FLJ22224; FLJ31718; FLJ41441; ABL2; EC 2.7.10.2
• Gene ID: 27
• mRNA Refseq: NM_005158
• Protein Refseq: NP_005149
• MIM: 164690
• UniProt ID: P42684
• Chromosome Location: 1q25.2
• Pathway: Developmental Biology; ErbB signaling pathway; Role of Abl in Robo-Slit signaling
• Function: ATP binding; magnesium ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding