ACOT9
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Official Full Name
acyl-CoA thioesterase 9
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Overview
The protein encoded by this gene is a mitochondrial acyl-CoA thioesterase of unknown function. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ACOT9; acyl-CoA thioesterase 9; acyl-coenzyme A thioesterase 9, mitochondrial; ACATE2; CGI 16; MT ACT48; acyl-CoA thioester hydrolase 9; mitochondrial Acyl-CoA Thioesterase; acyl-Coenzyme A thioesterase 2, mitochondrial; CGI-16; MTACT48; MT-ACT48;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | ACOT9-145H | Recombinant Human ACOT9 Protein, GST-Tagged | Wheat Germ | GST | ||
Human | ACOT9-9302H | Recombinant Human ACOT9, GST-tagged | E.coli | GST | 1-212a.a. | |
Human | ACOT9-15HCL | Recombinant Human ACOT9 cell lysate | N/A | |||
Human | ACOT9-5404H | Recombinant Human ACOT9 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | ACOT9-915HF | Recombinant Full Length Human ACOT9 Protein, GST-tagged | In Vitro Cell Free System | GST | 212 amino acids | |
Human | ACOT9-3818H | Recombinant Human ACOT9 protein, His-tagged | E.coli | His | 1-212 aa | |
Mouse | ACOT9-1207M | Recombinant Mouse ACOT9 Protein | Mammalian Cell | His | ||
Mouse | ACOT9-260M-B | Recombinant Mouse ACOT9 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | ACOT9-260M | Recombinant Mouse ACOT9 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | Acot9-1501M | Recombinant Mouse Acot9 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Chicken | ACOT9-2049C | Recombinant Chicken ACOT9 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ACOT9 involved in several pathways and played different roles in them. We selected most pathways ACOT9 participated on our site, such as Fatty Acyl-CoA Biosynthesis, Fatty acid, triacylglycerol, and ketone body metabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACOT9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Fatty Acyl-CoA Biosynthesis | ACSF3;ACOT9.1;THEM5;ACOT7;ACOT10;ACOT8;ELOVL1A;ACOT11A;ACSF2 |
Fatty acid, triacylglycerol, and ketone body metabolism | MED31;ACOT12;APOA5;AGPAT6;SLC25A20;ACOT2;ACOT11B;MED22;MED18 |
Metabolism | ACY3;NUDT5;ST3GAL3A;DHCR7;NUDT18;MED31;CYP2A13;CBLC-1;RHAG |
Metabolism of lipids and lipoproteins | APOF;CETP;INSIG1;CPTP;FAM213B;MED23;FA2H;G0S2;MED16 |
Triglyceride Biosynthesis | ACOT13;THEM5;TMEM195;ACOT9;DGAT1B;ELOVL1A;ACSF3;ACOT7;ACOT12 |
acyl-CoA hydrolysis | ACOT9;ACOT10 |
ACOT9 has several biochemical functions, for example, acetyl-CoA hydrolase activity, carboxylic ester hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACOT9 itself. We selected most functions ACOT9 had, and list some proteins which have the same functions with ACOT9. You can find most of the proteins on our site.
Function | Related Protein |
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acetyl-CoA hydrolase activity | ACOT12;NUDT7;ACOT9 |
carboxylic ester hydrolase activity | LYPLA2;ABHD5;LIPCA;ACOT7;Ces2c;FAM135A;ESD;LYPLAL1;FAM135B |
ACOT9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACOT9 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACOT9.
Nyap1; Nyap2; MYO16; PA; lysR; Ubr5; ssrna_ag; Dab2; ICT1; SIRT4; Shcbp1
- Q&As
- Reviews
Q&As (14)
Ask a questionACOT9 protein can be produced using recombinant DNA technology in bacterial, yeast, or mammalian expression systems. The ACOT9 gene can be inserted into a plasmid vector and transferred into the host cells, where it is transcribed and translated into protein. Purification of the recombinant protein can be achieved using chromatography techniques.
There is currently no evidence to suggest that ACOT9 protein can be used to improve athletic performance. However, as ACOT9 plays a role in energy metabolism and lipid utilization, it may be relevant in the context of exercise and metabolism. More research is needed to fully explore potential applications of ACOT9 in sports science and exercise physiology.
Currently, there are no drugs or therapies available that specifically target ACOT9 protein. However, there are some inhibitors that can reduce the activity of related enzymes, such as ACOT7 and ACOT8, which may have overlapping functions with ACOT9. Additionally, research is ongoing to develop drugs or therapies that target ACOT9 specifically.
As ACOT9 is a relatively new target for drug development, there is limited information on the potential side effects or toxicity of ACOT9-targeted therapies. However, studies have shown that ACOT9 inhibition can lead to alterations in lipid metabolism and energy balance. Potential side effects may also vary depending on the specific compound used to target ACOT9. More research is needed to determine the safety and efficacy of ACOT9-targeted therapies.
While ACOT9 has not been specifically studied as a therapeutic target for cancer treatment, some studies have suggested that this protein may play a role in certain aspects of cancer biology such as cell growth and proliferation. However, more research is needed to fully understand the role of ACOT9 in cancer and whether targeting this protein could be an effective therapeutic strategy.
ACOT9 protein levels and activity have been shown to be altered in metabolic disorders such as NAFLD and diabetes. Measuring ACOT9 protein levels in blood or tissue samples could potentially serve as a biomarker for these disorders, providing a non-invasive and cost-effective diagnostic tool. Additionally, ACOT9 protein may be used as a biomarker to monitor the effectiveness of ACOT9-targeted therapies.
Yes, ACOT9 has been identified as a potential target for the treatment of NAFLD. Inhibition of ACOT9 activity has been shown to decrease the accumulation of triglycerides in the liver and improve insulin sensitivity in animal models. However, further research is needed to determine the efficacy and safety of ACOT9-targeted therapies for the treatment of NAFLD in humans.
One of the main challenges in developing ACOT9-targeted therapies is the need to selectively target ACOT9 without affecting other proteins or pathways involved in cellular processes. Additionally, more research is needed to fully understand the mechanisms by which ACOT9 regulates lipid metabolism, cell signaling, and vesicular transport, and to identify safe and effective compounds that can modulate its activity.
ACOT9-targeted therapies may be customized for different patient populations by developing compounds that selectively target ACOT9 in specific tissues or cell types. This may involve modifying the chemical structure or delivery of the compound, or identifying specific biomarkers that indicate the presence or activity of ACOT9. Additionally, patient-specific factors such as disease severity and genetic background may influence the efficacy and safety of ACOT9-targeted therapies.
ACOT9 has been identified as a potential target for the treatment of obesity, as it plays a role in the breakdown of fatty acids and the regulation of lipid metabolism. However, further research is needed to determine the efficacy and safety of ACOT9-targeted therapies for the treatment of obesity in humans.
The potential side effects of ACOT9-targeted therapies are not fully understood, as there are currently no drugs or therapies available that specifically target ACOT9. However, it is possible that inhibition of ACOT9 activity could have negative effects on lipid metabolism or other cellular processes. Further research is necessary to fully evaluate the safety and efficacy of ACOT9-targeted therapies.
ACOT9 has been identified as a potential target for the treatment of diabetes, as it plays a role in the regulation of lipid metabolism and insulin sensitivity. Inhibition of ACOT9 activity has been shown to improve insulin sensitivity in animal models. However, further research is needed to determine the efficacy and safety of ACOT9-targeted therapies for the treatment of diabetes in humans.
Yes, ACOT9 protein can be used in biotechnology applications such as lipid production and modification. Its role in lipid metabolism makes it a potentially useful enzyme in bioprocessing applications. However, further research is needed to optimize the use of ACOT9 in these applications.
ACOT9 has been shown to regulate lipid metabolism by hydrolyzing or breaking down specific lipid molecules, including long-chain acyl-CoA derivatives. This activity helps to prevent the accumulation of excess lipids in cells and tissues. ACOT9 also plays a role in regulating the distribution and utilization of fatty acids within the body.
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