ACTN4
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Official Full Name
actinin, alpha 4
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Overview
The two major cytoskeletal proteins implicated in cell motility are actin and myosin. There are three a-actin (skeletal, cardiac, and smooth muscle), one b-actin (b ?nonmuscle), and two y-actins (y-smooth nuscle and y-nonmuscle). Antibody to b-actin provides a specific and useful tool in studying the intracellular distribution of b-actin and the static and dynamic aspects of the cytoskeleton. -
Synonyms
ACTN4; actinin, alpha 4; focal segmental glomerulosclerosis 1 , FSGS1; alpha-actinin-4; actinin alpha4 isoform; non-muscle alpha-actinin 4; F-actin cross-linking protein; focal segmental glomerulosclerosis 1; FSGS; FSGS1; ACTININ-4; DKFZp686K23158;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ACTN4 Related Articles
ACTN4 involved in several pathways and played different roles in them. We selected most pathways ACTN4 participated on our site, such as Focal adhesion, Adherens junction, Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTN4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Focal adhesion | PAK3;COL2A1B;TLN2A;SHC2;COL1A1A;ILK;ITGA6;ERBB2;COL6A2 |
| Adherens junction | LMO7;RHOAA;ACP1;CTNNA1;BAIAP2A;SMAD4;CTNNA2;PTBP3;LEF1 |
| Tight junction | MRAS;PPP2CA;MYLPFA;EPB41;JAM3B;CLDN11B;CLDNJ;CLDN9;MYL7 |
| Leukocyte transendothelial migration | ITGB2L;GNAI1;CYBA;CLDN18;CLDN8;CLDN4;ESAM;MYL7;PECAM1 |
| Regulation of actin cytoskeleton | GNA12;PIK3R3A;APC2;FGF6B;ARHGEF6;ITGA6B;RAC1B;ACTN3;PPP1CAA |
| Amoebiasis | LAMC3;COL4A3;Itgam&Itgb2;PRKCG;CXCL1;PTK2;LAMA3;COL3A1;RELA |
| Viral carcinogenesis | TRAF1;STAT5A;HIST1H4F;HIST1H4A;HNRNPK;RELA;HDAC4;CREB5;HIST1H2BN |
| Systemic lupus erythematosus | C8G;HLA-DRB5;HIST2H3A;HLA-DPA1;HIST1H2BO;CD40LG;HIST1H2BN;HIST1H2AP;HIST1H3G |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ITGA4;ITGAV;ITGA2B;JUP;CDH2;ACTB;LMNA;PKP2;ITGB6 |
ACTN4 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, actin binding, actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTN4 itself. We selected most functions ACTN4 had, and list some proteins which have the same functions with ACTN4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II regulatory region sequence-specific DNA binding | PAX9;ONECUT3;RELA;GFI1AA;BCL6AB;ATF3;ZFAT;RUNX3;BARHL2 |
| actin binding | PDLIM5;NEXN;PHACTR3B;CAMK2B;DIAP1;GAS2L3;FHL3;ADD2;GSNB |
| actin filament binding | NEXN;BLOC1S6;MYH9;CTNNAL1;FLNA;TTN;TRIOBP;RCSD1;ACTN2B |
| calcium ion binding | EFCAB12;CLSTN3;NCL;CAPNS1A;S100A6;EFCAB1;NUCB2;NOTCH2;PCDHGA11 |
| chromatin DNA binding | SLAMF7;PRDM14;VAX1;WBP2;SRF;ACTN4;H2AFY2;FOXC2;ATOH1 |
| integrin binding | AMICA1;NIPAL1;EDIL3;ITGB1;SEMA7A;ICAM5;ILK;CTGFB;GFAP |
| ion channel binding | RNF207;HOMER1;CALM;PKP2;CALM1;KCNE1L;NOS1;KCNE4;ASPH |
| ligand-dependent nuclear receptor transcription coactivator activity | SRA1;SLC30A9;PPRC1;ACTN1;HMGA1;TADA3;ZCCHC18;FGF2;MED30 |
| nuclear hormone receptor binding | CTNNB1;SMARCD3;CRY1;NCOA1;ACTN4;NCOA2;NCOR1;HIF1A;SIRT1 |
| nucleoside binding | POLA1;ACTN4;AASS;CDA;PNP |
| poly(A) RNA binding | FNDC3A;ATP5A1;TRA2B;ASCC3;MRPS12;FAM50A;RPS18;PPIA;YWHAZ |
| protein N-terminus binding | ALOX5AP;BIRC2;EXOC5;HDAC1;CHMP6;KCNQ2;EIF3E;STXBP1;ALG2 |
| protein binding | SMC1A;PDLIM4;RERG;TPSB2;PILRB;ESR2;RBM5;PTMA;CCT3 |
| protein homodimerization activity | CALCOCO2;ATG7;CARD9;STC2;ODC1;APOE;C16orf89;CADM1A;PRDM6 |
| retinoic acid receptor binding | PRAMEF1;CNOT1;NSD1;HMGA1;ACTN4;MED25;AASS;RXRA;LRIF1 |
ACTN4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTN4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTN4.
MYOZ2; CTNNB1; IQGAP1; TJP1
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