Recombinant Human ACTN4, GST-tagged
Cat.No. : | ACTN4-9342H |
Product Overview : | Recombinant Human ACTN4 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 611-911a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | ACTN4 actinin, alpha 4 [ Homo sapiens ] |
Official Symbol : | ACTN4 |
Synonyms : | ACTN4; actinin, alpha 4; focal segmental glomerulosclerosis 1 , FSGS1; alpha-actinin-4; actinin alpha4 isoform; non-muscle alpha-actinin 4; F-actin cross-linking protein; focal segmental glomerulosclerosis 1; FSGS; FSGS1; ACTININ-4; DKFZp686K23158; |
Gene ID : | 81 |
mRNA Refseq : | NM_004924 |
Protein Refseq : | NP_004915 |
MIM : | 604638 |
UniProt ID : | O43707 |
Chromosome Location : | 19q13 |
Pathway : | Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Cell-Cell communication, organism-specific biosystem; |
Function : | actin binding; actin filament binding; calcium ion binding; integrin binding; nucleoside binding; protein N-terminus binding; protein binding; protein homodimerization activity; |
Products Types
◆ Recombinant Protein | ||
ACTN4-2470H | Recombinant Human ACTN4 protein(391-860 aa), C-His-tagged | +Inquiry |
ACTN4-290M | Recombinant Mouse ACTN4 Protein, His (Fc)-Avi-tagged | +Inquiry |
Actn4-01M | Recombinant Mouse Actn4 Protein | +Inquiry |
ACTN4-272H | Recombinant Human ACTN4 Protein, His (Fc)-Avi-tagged | +Inquiry |
ACTN4-53R | Recombinant Rhesus Macaque ACTN4 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
ACTN4-9055HCL | Recombinant Human ACTN4 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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