Recombinant Human ACTN4, GST-tagged

• Cat.No.: ACTN4-9342H
• Product Overview: Recombinant Human ACTN4 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 611-911a.a.
• Description: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: ACTN4 actinin, alpha 4 [ Homo sapiens ]
• Official Symbol: ACTN4
• Synonyms: ACTN4; actinin, alpha 4; focal segmental glomerulosclerosis 1 , FSGS1; alpha-actinin-4; actinin alpha4 isoform; non-muscle alpha-actinin 4; F-actin cross-linking protein; focal segmental glomerulosclerosis 1; FSGS; FSGS1; ACTININ-4; DKFZp686K23158
• Gene ID: 81
• mRNA Refseq: NM_004924
• Protein Refseq: NP_004915
• MIM: 604638
• UniProt ID: O43707
• Chromosome Location: 19q13
• Pathway: Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Cell-Cell communication, organism-specific biosystem
• Function: actin binding; actin filament binding; calcium ion binding; integrin binding; nucleoside binding; protein N-terminus binding; protein binding; protein homodimerization activity