ADA

  • Official Full Name

    adenosine deaminase
  • Overview

    This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been;described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe;combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired;cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been;associated with congenital hemolytic anemia.
  • Synonyms

    ADA;adenosine deaminase;adenosine aminohydrolase

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • Rat
  • Zebrafish
  • Bovine
  • Insect Cells
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • E.Coli/Yeast
  • HEK293
  • Bovine Intestine
  • His
  • Non
  • GST
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
ADA-1112H Active Recombinant Human ADA protein, His-tagged Insect Cells Human His 1-363 a.a.
ADA-39H Active Recombinant Human ADA protein E.coli Human Non
ADA-40H Recombinant Human ADA Protein, 1-363aa, N-His tagged E.coli Human His 1-363aa
ADA-1007H Recombinant Human ADA, His-tagged E.coli Human His
ADA-1271M Recombinant Mouse ADA Protein Mammalian Cells Mouse His
ADA-1435C Recombinant Chicken ADA Mammalian Cells Chicken His
ADA-268H Recombinant Human ADA Protein, GST-tagged Wheat Germ Human GST
Ada-3155M Recombinant Mouse Ada, His-tagged E.Coli/Yeast Mouse His 352
ADA-3H Recombinant Human Adenosine Deaminase Human Non
ADA-499R Recombinant Rat ADA Protein Mammalian Cells Rat His
ADA-756Z Recombinant Zebrafish ADA Mammalian Cells Zebrafish His
ADA-001HCL Recombinant Human ADA cell lysate Insect Cells Human Non
ADA-0652H Recombinant Human ADA Protein (Lys11-Val280), N-His-tagged E.coli Human His Lys11-Val280
ADA-0689H Recombinant Human ADA Protein (Lys11-Val280) E.coli Human Non Lys11-Val280
ADA-155R Recombinant Rat ADA Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
ADA-155R-B Recombinant Rat ADA Protein Pre-coupled Magnetic Beads HEK293 Rat
ADA-303M Recombinant Mouse ADA Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
ADA-303M-B Recombinant Mouse ADA Protein Pre-coupled Magnetic Beads HEK293 Mouse
ADA-9H Human Adenosine deaminase Reference Standard Human Non
ADA-P036B Native Bovine adenosine deaminase therapeutic protein (Pegademase bovine) Bovine Intestine Bovine Non
Kit-1101 Adenosine Deaminase Activity Assay Kit (Colorimetric) Non
Kit-2148 Adenosine Deaminase Fluorometric Activity Assay Kit Non

    Involved Pathway

    ADA involved in several pathways and played different roles in them. We selected most pathways ADA participated on our site, such as C-MYB transcription factor network,Metabolic pathways,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism KCNG4,SLC52A3,ITPKA,APOC2,CYP2K22,NUDT10,ACOT10,CTRB1,TM9SF1,SLC5A6A
    Purine metabolism AMPD1,POLR2C,GMPR2,ENPP1,POLR2L,PDE6G,ITPA,PRPS1L1,PNP,AK8
    Metabolism of nucleotides DPYD,ADAL,DCK,GLRX,ADSSL1,DHODH,TM9SF1,UPP2,ADSS,PNP5B
    C-MYB transcription factor network MYOD1,LECT2,CSF1R,SMARCA2,SLC25A3,PTCRA,MYC,CEBPB,YEATS4,ELANE
    Primary immunodeficiency TNFRSF13C,CD3E; CD3D
    Purine salvage ADK,TM9SF1,PNP5B,DGUOK,DCK,ADAL
    Metabolic pathways ARG1,FBP1,ADSSL1,NME7,HOGA1,ATP6V1A,UGT2A3,SCP2A,PGM2,ATP5O

    Protein Function

    ADA has several biochemical functions, for example, adenosine deaminase activity,protein binding,purine nucleoside binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADA itself. We selected most functions ADA had, and list some proteins which have the same functions with ADA. You can find most of the proteins on our site.

    Function Related Protein
    adenosine deaminase activity ADAD1,ADAD2,CECR1A,ADARB2,ADARB1,CECR1,ADAL,ADARB1A
    zinc ion binding CHURC1,SYVN1,CUL9,MARCH8,NR1D2,TRAF2,LMO4A,NEIL3,ADAMTS15,MMP8
    protein binding USP15,APOBEC2B,TRA2B,PRDX1,MCM2,GTF2A1,PTPN2,RAB17,DDX20,AMHR2
    purine nucleoside binding ADORA1,C6orf130

    Interacting Protein

    ADA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADA here. Most of them are supplied by our site. Hope this information will be useful for your research of ADA.

    PIAS2;SGCD;TINF2;TERF2IP

    Resources

    References

    • Zhang, JC; Yu, BB; et al. Non-Normal Random Effects Models for Immunogenicity Assay Cut Point Determination. JOURNAL OF BIOPHARMACEUTICAL STATISTICS 25:295-306(2015).
    • Zandvliet, A; Glasgow, S; et al. Tildrakizumab, a novel anti-IL-23 monoclonal antibody, is unaffected by ethnic variability in Caucasian, Chinese, and Japanese subjects. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 53:139-146(2015).

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