Recombinant Human ADAMTS2 protein, His & SUMO-tagged

• Cat.No.: ADAMTS2-1778H
• Product Overview: Recombinant Human ADAMTS2 aa. (Gln23~Pro161) fused with N-terminal His & SUMO tag was produced in E. coli cells.

Specification

• Source: E. coli
• Species: Human
• Tag: His & SUMO
• Form: Freeze-dried powder
• Molecular Mass: 40kDa as determined by SDS-PAGE reducing conditions.
• Protein length: Gln23~Pro161
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >94%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Concentration: 200μg/mL
• Storage buffer: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300.
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
• Isoelectric Point: 4.2

Gene Information

• Gene Name: ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif 2 [ Homo sapiens (human) ]
• Official Symbol: ADAMTS2
• Synonyms: NPI; PNPI; PCINP; PCPNI; PCI-NP; PC I-NP; ADAM-TS2; ADAMTS-2; ADAMTS-3; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2; procollagen I N-proteinase; procollagen I/II amino propeptide-processing enzyme; procollagen N-endopeptidase; A disintegrin and metalloproteinase with thrombospondin motifs 2
• Gene ID: 9509
• mRNA Refseq: NM_014244.4
• Protein Refseq: NP_055059.2
• UniProt ID: O95450

Reviews

09/20/2022

The protein received was tailored to my needs, allowing me to move forward with my research.

10/15/2021

Technicians are able to provide helpful advice on product use.

03/01/2021

High protein concentrations were received and the desired experimental results were obtained.

06/30/2020

Smooth communication and timely shipment, allowing my experiment to be implemented as soon as possible.

06/28/2020

The sales staff gave me good advice and allowed me to purchase products that met my research needs.

Q&As

What protein does ADAMTS2 have the highest homology with?

ADAMTS2 has high sequence homology with ADAMTS14 and ADAMTS3.

How does ADAMTS2 affect the development of myocardial hypertrophy?

Overexpression of ADAMTS2 significantly improves cardiac function and inhibits the development of myocardial hypertrophy, meaning that ADAMTS2 plays a protective role in the development of cardiac hypertrophy.

Can the tag of Recombinant Mouse Adamts2 be removed?

Yes, we are able to provide custom manufactured ADAMTS2 according to your needs.

What is the physiological function of ADAMTS2?

ADAMTS2 affects the pathogenesis of cardiovascular disease and regulates myocardial hypertrophy.

Do you offer ADAMTS2 (GST-tagged)?

We can custom produce ADAMTS2 (GST-tagged) for you.

In which tissues is ADAMTS2 mainly expressed?

ADAMTS2 is mainly expressed in connective tissues extending from the lymphatic network.

What are the effects of mutations in the ADAMTS2 gene?

Mutations in the ADAMTS2 gene cause abnormal skin development in animals and congenital connective tissue dysplasia syndrome in humans.

What substances promote the secretion of ADAMTS2?

Both cytokines TNF-α and TGF-β promote the secretion of ADAMTS2.

What diseases is ADAMTS2 currently used in research?

ADAMTS2 is widely used in cardiovascular disease research.

Will His affect my downstream experiments?

Due to the small molecular weight of the His tag, it generally does not affect the downstream application of the protein.