adarb1 Protein, adenosine deaminase, RNA-specific, B1


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Official Full Name adenosine deaminase, RNA-specific, B1
Background This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region.
Synonyms ADARB1; adenosine deaminase, RNA-specific, B1; adenosine deaminase, RNA specific, B1 (homolog of rat RED1); double-stranded RNA-specific editase 1; ADAR2; ADAR2a; ADAR2a L1; ADAR2a L2; ADAR2a L3; ADAR2b; ADAR2c; ADAR2d; ADAR2g; DRABA2; DRADA2; hRED1; RED1; RED1 homolog (rat); ADARB 1; 1700057H01Rik; Adenosine deaminase, RNA specific, 2; Adenosine deaminase, RNA specific, B1 (RED1 homolog rat); Adenosine deaminase, RNA specific, B1; AW124433; AW558573; BB220382; D10Bwg0447e; Double stranded RNA specific editase 1; dsRNA adenosine deaminase; EC 3.5.-.-; Human dsRNA adenosine deaminase DRADA2; Human dsRNA adenosine deaminase DRADA2b, EC 3.5; OTTHUMP00000115341; OTTHUMP00000115342; RED 1; RNA editase; RNA editase 1; RNA editing deaminase 1; RNA editing enzyme 1; RNA editing enzyme 1, rat, homolog of; RNA specific adenosine deaminase B1; RED1 homolog; OTTHUMP00000115339; OTTHUMP00000115340; OTTHUMP00000174981; OTTHUMP00000214128; RNA-editing enzyme 1; RNA-editing deaminase 1; dsRNA ad
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Adarb1-473M Recombinant Mouse Adarb1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human ADARB1-1147H Recombinant Human ADARB1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ADARB1-28HCL Recombinant Human ADARB1 cell lysate N/A
    Human ADARB1-314H Recombinant Human ADARB1 Protein, GST-tagged Wheat Germ GST
    Human ADARB1-315H Recombinant Human ADARB1 Protein, GST-tagged Wheat Germ GST
    Rat ADARB1-511R Recombinant Rat ADARB1 Protein Mammalian Cell His
    Chicken ADARB1-3775C Recombinant Chicken ADARB1 Mammalian Cell His
    Chicken ADARB1-5813C Recombinant Chicken ADARB1 Mammalian Cell His

    adarb1 involved in several pathways and played different roles in them. We selected most pathways adarb1 participated on our site, such as C6 deamination of adenosine, Formation of editosomes by ADAR proteins, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with adarb1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    C6 deamination of adenosine ADARB1A; ADAR; ADARB1
    Formation of editosomes by ADAR proteins ADAR; ADARB1A; ADARB1
    Gene Expression HNRNPA0L; IGF2BP3; ZNF286A; ZFP28; ZNF213; MED8; CLP1; SMG9; NR1D2B; SNAPC3
    mRNA Editing: A to I Conversion ADARB1A; ADARB1

    adarb1 has several biochemical functions, for example, RNA binding, adenosine deaminase activity, double-stranded RNA adenosine deaminase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by adarb1 itself. We selected most functions adarb1 had, and list some proteins which have the same functions with adarb1. You can find most of the proteins on our site.

    Function Related Protein
    adenosine deaminase activity ADARB2; CECR1; ADAL; ADAD1; CECR1A; ADAD2; ADARB1A; ADA; ADARB1
    double-stranded RNA adenosine deaminase activity ADAR; ADARB1; PKZ; ZBP1
    double-stranded RNA binding VIM; HSPD1; TUBA1B; EIF2AK2; PRKRIP1; OAS1A; OAS1; ACTN1; TUBB4B; ELAVL1
    mRNA binding CSTF2; EIF4A3; LUC7L2; TDRD7; PARK7; RPL13A; RBM38; FXR1; NUDT21; HSP26
    metal ion binding CYP4F18; ACSM2B; MICALL2B; GMIP; ZNF317; HDAC9; FAM170A; ZNF436; CA15B; MGAT4B
    poly(A) RNA binding YTHDF2; EIF2S2; HELZ; EIF4A2; HIST1H47; CD3EAP; HNRPDL; CDKN2A; ESF1; MYO18A
    protein binding FUS; RPS6KA5; CAMK1; GTF2IRD2; ARHGEF38; NBR1; GMPPB; DLA; GFM2; ILF3

    adarb1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with adarb1 here. Most of them are supplied by our site. Hope this information will be useful for your research of adarb1.

    PIN1; WWP2; HNRNPA1; Rpl35; Ufl1

    Allegra, D; Bilan, V; et al. Defective DROSHA processing contributes to downregulation of MiR-15/-16 in chronic lymphocytic leukemia. LEUKEMIA 28:98-107(2014).
    Mertens, D; Allegra, D; et al. ADARB1 Is Involved In a Reduced Maturation Of The miR15a/Mir-16-1 Family In Chronic Lymphocytic Leukemia. BLOOD 122:-(2013).

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