ADCYAP1
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Official Full Name
adenylate cyclase activating polypeptide 1 (pituitary)
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Overview
Pituitary adenylate cyclase-activating polypeptide also known as PACAP is a protein that in humans is encoded by the ADCYAP1 gene. PACAP is similar to vasoactive intestinal peptide. One of its effects is to stimulate enterochromaffin-like cells. It binds to vasoactive intestinal peptide receptor. -
Synonyms
ADCYAP1; PACAP; adenylate cyclase activating polypeptide 1 (pituitary); pituitary adenylate cyclase-activating polypeptide; MGC126852; OTTHUMP00000162201; PACAP 38; PRP-48; Pituitary adenylate cyclase-activating polypeptide 27; PACAP-27; PACAP27; Pituitary adenylate cyclase-activating polypeptide 38; PACAP-38; PACAP38;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|T7
- Myc
- DDK
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
ADCYAP1 involved in several pathways and played different roles in them. We selected most pathways ADCYAP1 participated on our site, such as Activation of TRKA receptors, Class B/2 (Secretin family receptors), G alpha (s) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADCYAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Activation of TRKA receptors | ADCYAP1;ADCYAP1R1;ADORA2A;NTF7 |
Class B/2 (Secretin family receptors) | PTH2;RAMP2;GHRH;FZD10;ADM2;PTHLHA;EMR4;ADCYAP1B;GNB3A |
G alpha (s) signalling events | PTHLHA;ADORA2A;RXFP2B;NPSR1;ADM2;CRH;POMCB;CALCB;ADCYAP1B |
GPCR downstream signaling | PLEKHG2;GNA13B;EDNRA;LPAR2B;RXFP2;LPAR1;CRHB;LPAR5A;EDN1 |
GPCR ligand binding | ADM2A;CCL35.2;PYYA;TAC2;LTB4R;LPAR2A;CALCA;HEBP1;OXGR1A.2 |
Insulin secretion | SLC2A2;GNAQ;ATF4;TRPM4;GPR119;CAMK2A;PDX1;KCNMB2;KCNJ11 |
NGF signalling via TRKA from the plasma membrane | DNAL4A;RIT2;KIDINS220B;ADCYAP1;NTF7;DNAL4;DNAL4B;RIT1 |
ADCYAP1 has several biochemical functions, for example, neuropeptide hormone activity, peptide hormone receptor binding, pituitary adenylate cyclase activating polypeptide activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADCYAP1 itself. We selected most functions ADCYAP1 had, and list some proteins which have the same functions with ADCYAP1. You can find most of the proteins on our site.
Function | Related Protein |
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neuropeptide hormone activity | POMCA;CORT;NPFFL;CCK;GAL;CRH;PPY;PYY;ADCYAP1 |
peptide hormone receptor binding | RUNDC3A;NPPA;PTHLHA;PTPN11;JAK2;NPPC;PTHLH;ADCYAP1;FYN |
pituitary adenylate cyclase activating polypeptide activity | |
protein binding | GAD1;RABGAP1L;PKP4;UBE2G2;SHMT1;MRPS27;YY1;MTCH1;APOBEC2A |
receptor binding | PVRL3;ZAP70;FGF13B;IDH1;HLA-B;INSL3;SMARCD1;ACOT2;HCST |
receptor signaling protein activity | RGS14A;CD19;TRAIP;DCLK1;ADRB1;ARF1;SMAD1;PLCG1;IFITM1 |
ADCYAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADCYAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADCYAP1.
CLU; DPP4; FAP
- Q&As
- Reviews
Q&As (13)
Ask a questionADCYAP1 is not currently being used as a treatment for Alzheimer's disease. However, there are ongoing studies investigating the use of ADCYAP1 and its analogues as potential therapeutics for the treatment of cognitive impairment in Alzheimer's disease and other neurodegenerative disorders.
ADCYAP1 can be used as a potential therapeutic target for the treatment of inflammatory disorders. Drugs that target ADCYAP1 could potentially inhibit the production of pro-inflammatory cytokines and increase the levels of anti-inflammatory cytokines, leading to a reduction in inflammation.
ADCYAP1 can be used as a potential therapeutic target for the treatment of migraines. Drugs that target ADCYAP1 could potentially block its activity and reduce the release of neuropeptides like substance P and CGRP that are involved in migraine pain sensitization.
The potential side effects of targeting ADCYAP1 are currently unknown, as there are no drugs targeting this protein that have reached clinical trials. However, the complex regulation and interactions of ADCYAP1 with other systems, such as the immune system, may increase the risk of side effects. In addition, as ADCYAP1 plays a role in various physiological processes, targeting it may have unintended effects beyond the intended therapeutic target.
There are currently no drugs targeting ADCYAP1 that have been approved by regulatory agencies for clinical use. However, there are ongoing preclinical studies investigating the use of ADCYAP1 and its analogues as potential therapeutics for various conditions, including Alzheimer's disease, diabetes, and inflammatory disorders.
Targeting ADCYAP1 protein may have therapeutic applications in various diseases and conditions, including migraine headache, Alzheimer's disease, schizophrenia, diabetes, and inflammatory disorders.
Various approaches are being explored for targeting ADCYAP1 protein in drug development, including small molecule inhibitors, monoclonal antibodies, and gene therapy. Small molecule inhibitors that target ADCYAP1 activity or expression are being developed and tested in preclinical studies. Monoclonal antibodies that bind to ADCYAP1 or its receptors are being developed for diagnostic and therapeutic purposes. Gene therapy approaches are being explored to deliver ADCYAP1-targeted therapeutics to specific tissues.
As of 2021, there are no drugs targeting ADCYAP1 that have reached clinical trials. However, several small molecule inhibitors of ADCYAP1 are being developed by pharmaceutical companies and tested in preclinical studies.
ADCYAP1 has anti-inflammatory properties and has been shown to regulate the function of immune cells such as macrophages and T cells. It reduces inflammation by inhibiting the production of pro-inflammatory cytokines and increasing the levels of anti-inflammatory cytokines. Elevated levels of ADCYAP1 have been found in the synovial fluid of patients with rheumatoid arthritis, suggesting that it may play a role in modulating the inflammatory response in this disorder.
ADCYAP1 can be used as a potential therapeutic target for the treatment of diabetes. Drugs that target ADCYAP1 could potentially stimulate insulin release from pancreatic beta cells and enhance insulin sensitivity in peripheral tissues, leading to improved glucose homeostasis.
As ADCYAP1 is involved in various physiological processes and diseases, potential biomarkers for monitoring the efficacy of ADCYAP1-targeted therapies may depend on the disease or condition being treated. For example, in migraine headache, biomarkers such as headache frequency and severity, medication use, and neuroimaging measures may be used. In Alzheimer's disease, biomarkers such as cognitive function and neuroimaging measures may be monitored. In diabetes, biomarkers such as blood glucose levels and insulin sensitivity may be measured.
ADCYAP1 has neuroprotective properties and has been shown to improve cognitive function in animal models of Alzheimer's disease. It also regulates the production and clearance of beta-amyloid, a protein that accumulates in the brains of Alzheimer's patients and is associated with neurodegeneration. However, studies have also shown that elevated levels of ADCYAP1 in the brain may contribute to the formation of tau protein, another hallmark of Alzheimer's disease pathology.
One challenge in developing ADCYAP1-targeted therapies is that ADCYAP1 is not the only neuropeptide that plays a role in the physiological processes and diseases in which it is implicated. Its physiological effects may also depend on its interactions with other neuropeptides, receptors, and signaling pathways. Additionally, the complex regulation and interactions of ADCYAP1 with other systems, such as the immune system, may complicate the design and optimization of ADCYAP1-targeted therapeutics.
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