ADD2
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Official Full Name
adducin 2 (beta)
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Overview
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. -
Synonyms
ADD2; adducin 2 (beta); beta-adducin; ADDB; ADD 2; ADDB_HUMAN; Adducin2; Beta adducin; Erythrocyte adducin subunit beta; OTTHUMP00000203378; OTTHUMP00000203908;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ADD2 Related Articles
ADD2 involved in several pathways and played different roles in them. We selected most pathways ADD2 participated on our site, such as Miscellaneous transport and binding events, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Miscellaneous transport and binding events | MRS2;ADD3;CTNS;ANKH;EPB49;NIPAL3;ADD3A;NIPA1;ADD2 |
Transmembrane transport of small molecules | SLC9A8;ANO5;ATP10A;SRI;RHCGL1;SLC4A4A;ATP1A1A.5;SLC20A2;SLC4A8 |
ADD2 has several biochemical functions, for example, actin binding, actin filament binding, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADD2 itself. We selected most functions ADD2 had, and list some proteins which have the same functions with ADD2. You can find most of the proteins on our site.
Function | Related Protein |
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actin binding | MED28;MSRB1A;VASPA;SPTBN1;EPB41L3A;GC;MYHZ1.2;SMYHC1;DIAPH1 |
actin filament binding | SHROOM3;AIF1L;ACTN1;BLOC1S6;FSCN1A;MYH11;GAS2L2;MYH3;PKNOX2 |
calmodulin binding | SPHK1;MYH7;MYH9;MYLK;SNTA1;CAMK2D1;MARCKSL1;SNTB1;CAMK2G1 |
protein heterodimerization activity | ITGB1;SLC51A;SLC3A1;AXL;WHRN;RAB3GAP2;TLX1;DVL3;RBP4 |
protein homodimerization activity | RAB11FIP4B;MTMR2;ASCL1;DAPK3;SYNDIG1;DMRT3A;DMRT2B;ABCD1;GLA |
spectrin binding | CAMSAP1;MYO7A;CAMSAP1L1;STX4A;MYO10;UNC13A;SLC26A5;ANK1;ADD1 |
ADD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADD2.
- Q&As
- Reviews
Q&As (10)
Ask a questionThere may exist small molecules or drugs that selectively modulate the activity or stability of ADD2.
ADD2 interacts with specific proteins or binding partners, and these interactions can be context-dependent.
The expression profile of ADD2 varies across different tissues and cell types.
ADD2 regulates downstream signaling pathways or target molecules that contribute to its cellular functions.
Specific antibodies or probes can be developed to visualize the localization or dynamics of ADD2 in live cells or tissues.
Post-translational modifications, such as phosphorylation or ubiquitination, occur on ADD2 and can influence its function.
Functional domains or motifs within ADD2 can be identified and characterized.
The expression of ADD2 can be regulated during development or in response to specific stimuli.
Modulating the expression or activity of ADD2 can impact cellular processes like cytoskeletal organization, cell motility, or membrane dynamics.
ADD2 exhibits subcellular localization, and its localization may undergo dynamic changes or translocation.
Customer Reviews (2)
Write a reviewHighly sensitive in bioactivity assays, accurately detecting the activity and concentration of bioactive factors.
Provides accurate and reliable quantification of protein biomarkers in clinical samples.
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