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Recombinant Human ADD2 Protein, GST-tagged

Cat.No. : ADD2-337H
Product Overview : Human ADD2 full-length ORF ( AAH65525.1, 1 a.a. - 726 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 107.2 kDa
AA Sequence : MSEETVPEAASPPPPQGQPYFDRFS EDDPEYMRLRNRAADLRQDFNLMEQ KKRVTMILQSPSFREELEGLIQEQM KKGNNSSNIWALRQIADFMASTSHA VFPTSSMNVSMMTPINDLHTADSLN LAKGERLMRCKISSVYRLLDLYGWA QLSDTYVTLRVSKEQDHFLISPKGV SCSEVTASSLIKVNILGEVVEKGSS CFPVDTTGFCLHSAIYAARPDVRCI IHLHTPATAAVSAMKWGLLPVSHNA LLVGDMAYYDFNGEMEQEADRINLQ KCLGPTCKILVLRNHGVVALGDTVE EAFYKIFHLQAACEIQVSALSSAGG VENLILLEQEKHRPHEVGSVQWAGS TFGPMQKSRLGEHEFEALMRMLDNL GYRTGYTYRHPFVQEKTKHKSEVEI PATVTAFVFEEDGAPVPALRQHAQK QQKEKTRWLNTPNAYLRVNVADEVQ RSMGSPRPKTTWMKADEVEKSSSGM PIRIENPNQFVPLYTDPQEVLEMRN KIREQNRQDVKSAGPQSQLLASVIA EKSRSPSTESQLMSKGDEDTKDDSE ETVPNPFSQLTDQELEEYKKEVERK KLELDGEKETAPEEPGSPAKSAPAS PVQSPAKEAETKSPLVSPSKSLEEG TKKTETSKAATTEPETTQPEGVVVN GREEEQTAEEILSKGLSQMTTSADT DVDTSKDKTESVTSGPMSPEGSPSK SPSKKKKKFRTPSFLKKSKKKEKVE S
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ADD2 adducin 2 (beta) [ Homo sapiens ]
Official Symbol : ADD2
Synonyms : ADD2; adducin 2 (beta); beta-adducin; ADDB; erythrocyte adducin subunit beta;
Gene ID : 119
mRNA Refseq : NM_001185054
Protein Refseq : NP_001171983
MIM : 102681
UniProt ID : P35612

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Are there any small molecules or drugs that can selectively modulate the activity or stability of ADD2? 09/20/2022

There may exist small molecules or drugs that selectively modulate the activity or stability of ADD2.

Are there specific interacting proteins or binding partners that associate with ADD2 in a cell- or context-specific manner? 05/19/2021

ADD2 interacts with specific proteins or binding partners, and these interactions can be context-dependent.

What is the expression profile of ADD2 in different tissues and cell types? 04/27/2020

The expression profile of ADD2 varies across different tissues and cell types.

What are the downstream signaling pathways or target molecules regulated by ADD2, and how do they contribute to its cellular functions? 02/16/2020

ADD2 regulates downstream signaling pathways or target molecules that contribute to its cellular functions.

Can specific antibodies or probes be developed to visualize the localization or dynamics of ADD2 in live cells or tissues? 05/07/2019

Specific antibodies or probes can be developed to visualize the localization or dynamics of ADD2 in live cells or tissues.

What post-translational modifications, such as phosphorylation or ubiquitination, occur on ADD2 and how do they impact its function? 02/15/2017

Post-translational modifications, such as phosphorylation or ubiquitination, occur on ADD2 and can influence its function.

Can the functional domains or motifs within ADD2 be identified and characterized? 02/06/2017

Functional domains or motifs within ADD2 can be identified and characterized.

How is the expression of ADD2 regulated during development or in response to specific stimuli? 07/30/2016

The expression of ADD2 can be regulated during development or in response to specific stimuli.

What are the consequences of modulating the expression or activity of ADD2 on cellular processes like cytoskeletal organization, cell motility, or membrane dynamics? 07/15/2016

Modulating the expression or activity of ADD2 can impact cellular processes like cytoskeletal organization, cell motility, or membrane dynamics.

What is the subcellular localization of ADD2 within cells? Does it exhibit any dynamic localization or translocation? 07/07/2016

ADD2 exhibits subcellular localization, and its localization may undergo dynamic changes or translocation.

Customer Reviews (2)

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Reviews
12/07/2021

    Highly sensitive in bioactivity assays, accurately detecting the activity and concentration of bioactive factors.

    05/31/2017

      Provides accurate and reliable quantification of protein biomarkers in clinical samples.

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