Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

ADH5

  • Official Full Name

    alcohol dehydrogenase 5 (class III), chi polypeptide

  • Overview

    This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene.
  • Synonyms

    ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide; FDH, formaldehyde dehydrogenase; alcohol dehydrogenase class-3; ADH 3; ADHX; Alcohol dehydrogenase (class III) chi polypeptide; alcohol dehydrogenase 5 (class III) chi polypeptide; Alcohol dehydrogenase class 3; Alcohol dehydrogenase class chi chain; Alcohol dehydrogenase class III; class III alcohol dehydrogenase 5 chi subunit; FDH; formaldehyde dehydrogenase; Glutathione dependent formaldehyde dehydrogenase; hydroxymethyllutathione dehydrogenase; OTTHUMP00000219913; alcohol dehydrogenase class-III; S-(hydroxymethyl)glutathione dehydrogenase; glutathione-dependent formaldehyde dehydrogenase; alcohol dehydroge; ADH-3; FALDH; GSNOR; GSH-FDH;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADH5-27095TH Recombinant Human ADH5, His-tagged E.coli His
Human ADH5-349H Recombinant Human ADH5 Protein, GST-tagged Wheat Germ GST
Human ADH5-13564H Recombinant Human ADH5, His-tagged E.coli His 1-374a.a.
Human ADH5-30HCL Recombinant Human ADH5 cell lysate N/A
Human ADH5-1370H Recombinant Human ADH5 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ADH5-4736H Recombinant Human ADH5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ADH5-284H Recombinant Human ADH5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ADH5-2488H Recombinant Human ADH5 protein, GST-tagged E.coli GST 2-374aa
Human ADH5-26H Recombinant Human ADH5 Protein, His-tagged E. coli His 1-374 aa
Human ADH5-2175HFL Recombinant Full Length Human ADH5 Protein, C-Flag-tagged Mammalian cells Flag
Human ADH5-0257H Recombinant Human ADH5 Protein (M1-I374), GST tagged E.coli GST M1-I374
Human ADH5-0256H Recombinant Human ADH5 Protein (M1-I374), Tag Free E.coli No tag M1-I374
Human ADH5-1317H Recombinant Human ADH5 Protein (2-374 aa), His-tagged Yeast His 2-374 aa
Human ADH5-284H-B Recombinant Human ADH5 Protein Pre-coupled Magnetic Beads HEK293
Human ADH5-927HF Recombinant Full Length Human ADH5 Protein, GST-tagged In Vitro Cell Free System GST 374 amino acids
Mouse ADH5-1355M Recombinant Mouse ADH5 Protein Mammalian Cell His
Mouse Adh5-543M Recombinant Mouse Adh5 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse ADH5-344M-B Recombinant Mouse ADH5 Protein Pre-coupled Magnetic Beads HEK293
Mouse ADH5-344M Recombinant Mouse ADH5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ADH5-524R Recombinant Rat ADH5 Protein Mammalian Cell His
Rat Adh5-3257R Recombinant Rat Adh5, His-tagged E.Coli or Yeast His 374
Rat ADH5-180R-B Recombinant Rat ADH5 Protein Pre-coupled Magnetic Beads HEK293
Rat ADH5-180R Recombinant Rat ADH5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ADH5-9355Z Recombinant Zebrafish ADH5 Mammalian Cell His
Chicken ADH5-2824C Recombinant Chicken ADH5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ADH5 involved in several pathways and played different roles in them. We selected most pathways ADH5 participated on our site, such as Biological oxidations, Biosynthesis of antibiotics, Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADH5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Biological oxidationsCYP3A5;Sult2a2;CYP3A7;ADH8A;CYP7A1;CYP2N13;AKR1A1;CYP4T8;GLYAT
Biosynthesis of antibioticsUAP1L1;AK8;BPNT1;GALM;LDHAL6B;AK7;ANI_1_2390104;EHHADH;SDSL
Carbon metabolismIDH2;TKTB;PFKMB;MCEE;GOT2;HAO1;RPE;FH;FBP1
Chemical carcinogenesisADH1;CYP2C39;CYP2C37;MGST2;ADH5;GSTP1;UGT1A7C;CYP3A7-CYP3AP1;GSTO2
Degradation of aromatic compoundsAKR1A1A;AKR1A1;RGN;ADH5;AKR1A1B
Drug metabolism - cytochrome P450ADH1C;ADH5;CYP2E1;GSTK1;CYP3A5;GSTO2;ADH4;CYP2C8;ADH2-1
Ethanol oxidationADH1B;ADH1C;ADH1A;ADH4;ADH8A;ADH6;ADH5;ADH8B;ADH7
Fatty acid degradationADH1A;ADH1;ADH7;ADH4;ACSL4B;GCDHA;PECI;ACOX1;ALDH3A2A

ADH5 has several biochemical functions, for example, S-(hydroxymethyl)glutathione dehydrogenase activity, alcohol dehydrogenase (NAD) activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADH5 itself. We selected most functions ADH5 had, and list some proteins which have the same functions with ADH5. You can find most of the proteins on our site.

Function Related Protein
S-(hydroxymethyl)glutathione dehydrogenase activity
alcohol dehydrogenase (NAD) activityADH6;ADH1A;ADH7;ADH8A;ADH1C;ADH8B;ADH1;ADH5;DHRS9
electron carrier activityAOC2;DHDH;NCF2;XDH;GLDC;AKR1A1;AKR7A3;GPX2;FDX1B
fatty acid bindingFABP1;FABP2;FABP10A;FABP5;NDUFAB1;PTGDS;FABP4;ADH5;HNF4A
formaldehyde dehydrogenase activityADH5;ADH8B
protein homodimerization activityRBM44;PON3;FGFR1OP;NOS1;ERCC5;FLNA;SRM;BMP4;NRF1
zinc ion bindingS100A5;S100A12;RC3H1;FBXO11A;RNF183;TRIM31;ADAM1B;TRIM63;NANOS2

ADH5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADH5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADH5.

VTN; ESRRA; ARNT; CSNK2B; PRDX1; CHD3; PQLC1; HDAC1

  • Q&As
  • Reviews

Q&As (10)

Ask a question
What is the tissue-specific expression pattern of ADH5, and how is its expression regulated under normal physiological conditions and in response to specific stimuli? 03/07/2022

ADH5 exhibits a tissue-specific expression pattern, and its expression is regulated by various factors such as transcriptional control and signaling pathways.

Can ADH5 efficiently metabolize different alcohol substrates, and how does its substrate specificity compare to other ADH enzymes? 09/21/2021

ADH5 can efficiently metabolize different alcohol substrates, and its substrate specificity may differ from other ADH enzymes.

How does ADH5 expression and activity change in response to chronic alcohol exposure or alcohol withdrawal, and what are the molecular mechanisms underlying these changes? 09/03/2021

ADH5 expression and activity can be influenced by chronic alcohol exposure or withdrawal, and studying the underlying molecular mechanisms can shed light on alcohol-related effects.

Can the activity or function of ADH5 be modulated by pharmacological agents or environmental factors, and are there potential therapeutic implications? 08/17/2020

The activity or function of ADH5 can potentially be modulated by pharmacological agents or environmental factors, presenting potential therapeutic implications.

Are there any specific interacting proteins or cofactors that influence the activity or function of ADH5, and what are the underlying molecular mechanisms? 07/30/2020

Interacting proteins or cofactors can modulate the activity or function of ADH5, and investigating the molecular mechanisms involved can enhance our understanding of its regulation.

What are the enzymatic kinetics and catalytic properties of ADH5, and how do they contribute to its overall activity? 11/23/2019

The enzymatic kinetics and catalytic properties of ADH5 contribute to its overall activity and efficiency in alcohol metabolism.

Can ADH5 play a role in the metabolism of other endogenous compounds or xenobiotics, and if so, what are the implications for its broader physiological functions? 05/10/2019

ADH5 may have implications in the metabolism of other endogenous compounds or xenobiotics, suggesting its involvement in broader physiological functions.

Are there any known genetic variations or polymorphisms in the ADH5 gene associated with altered alcohol metabolism or susceptibility to alcohol-related disorders? 06/13/2018

Genetic variations or polymorphisms in the ADH5 gene may impact alcohol metabolism and susceptibility to alcohol-related disorders, emphasizing the role of genetic factors in its function.

What are the structural features of ADH5, and how do they contribute to its catalytic activity and binding affinity for alcohol? 02/08/2017

The structural features of ADH5 play a crucial role in its catalytic activity and binding affinity for alcohol, and understanding these features provides insights into its function.

What is the impact of ADH5 deficiency or overexpression on alcohol metabolism and its physiological consequences? 06/05/2016

Exploring the consequences of ADH5 deficiency or overexpression provides insights into its role in alcohol metabolism and its impact on physiological processes.

Customer Reviews (2)

Write a review
Reviews
07/29/2022

    Highly effective in stabilizing and enhancing the activity of enzymes in enzyme engineering.

    05/29/2016

      Demonstrates excellent resistance to aggregation and aggregation-prone conditions.

      Ask a Question for All ADH5 Products

      Required fields are marked with *

      My Review for All ADH5 Products

      Required fields are marked with *

      logo

      FOLLOW US

      Terms and Conditions        Privacy Policy

      Copyright © 2024 Creative BioMart. All Rights Reserved.

      Contact Us

      • /

      Stay Updated on the Latest Bioscience Trends