ADH7
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Official Full Name
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
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Overview
This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. -
Synonyms
ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; alcohol dehydrogenase class 4 mu/sigma chain; ADH 4; ADH 7; ADH4; Alcohol dehydrogenase class IV mu/sigma chain; Gastric alcohol dehydrogenase; Retinol dehydrogenase; alcohol dehydrogenase-7; alcohol dehydrogenase VII; class IV sigma-1 alcohol dehydrogenase; class IV sigmasigma alcohol dehydrogenase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- His
- GST
- His (Fc)
- Avi
- His|SUMO
- MYC
- DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
ADH7 involved in several pathways and played different roles in them. We selected most pathways ADH7 participated on our site, such as Biological oxidations, Chemical carcinogenesis, Drug metabolism - cytochrome P450, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADH7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Biological oxidations | DPEP2;UGT1B2;CYP2R1;SLC35B2;ACY3;ABHD14B;AS3MT;CYP2C19;CYP2AD2 |
Chemical carcinogenesis | SULT1A2;UGT1A7;CYP2A13;CYP2E1;UGT2A1;ADH6;ADH1B;CYP2C9;CYP3A7 |
Drug metabolism - cytochrome P450 | ADH1A;CYP2C8;CYP2C19;CYP2B6;CYP3A5;ADH7;CYP2E1;ADH2-1;ADH2-2 |
Ethanol oxidation | ADH8B;ADH1A;ADH8A;ADH1B;ADH1C;ADH7;ADH6;ADH5;ADH4 |
Fatty Acid Omega Oxidation | ADH1B;CYP4A11;ADH1A;CYP2E1;CYP1A1;CYP2D6;ADH7;CYP2A6;ADH1C |
Fatty acid degradation | ALDH1B1;ALDH2;ACADM;CYP4A12A;ADH5;ALDH2.1;CPT2;CPT1B;ACSL1A |
Glycolysis / Gluconeogenesis | ADPGK;ENO2;ALDH1A3;ADH6;PDHA2;LDHAL6A;PGAM1;AKR1A1B;PKM2 |
Metabolic pathways | CMASA;ALPL;ADH4;IDH3B;COQ6;MTMR1B;PCCB;TKT;NANP |
ADH7 has several biochemical functions, for example, alcohol dehydrogenase (NAD) activity, alcohol dehydrogenase activity, zinc-dependent, aldehyde oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADH7 itself. We selected most functions ADH7 had, and list some proteins which have the same functions with ADH7. You can find most of the proteins on our site.
Function | Related Protein |
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alcohol dehydrogenase (NAD) activity | ADH4;ADH1A;ADH5;ADH6;ADH1C;DHRS9;ADH8A;ADH8B;ADH1 |
alcohol dehydrogenase activity, zinc-dependent | ADH7;ADH4;ADH1B;ADH1A |
aldehyde oxidase activity | AOX1;AOX4;ADH7;AOX3;AOX3L1 |
ethanol binding | ADH1;ADH7;ADH4;PRKCE |
receptor antagonist activity | LRPAP1;DKK1;IL18BP;ESR2;AGTR2;ADH7 |
retinol binding | ADH7;RLBP1;RBP7;RBP3;C8G;RBP4;RBP1;RBP5;CRABP2 |
retinol dehydrogenase activity | HSD17B6;ADH4;RDH8;RDH5;ADH7;RDH11;DHRS7C;SDR9C7;RDH12 |
zinc ion binding | ISL2;SIRT5;ADAM8A;MMP14A;UBR3;NSD1;ADH7;RNF13;BHMT2 |
ADH7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADH7 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADH7.
- Q&As
- Reviews
Q&As (10)
Ask a questionADH7 can interact with specific partners or cofactors that modulate its activity or function, and studying the underlying molecular mechanisms elucidates its regulatory mechanisms.
Genetic variations or polymorphisms in the ADH7 gene may impact alcohol metabolism and susceptibility to alcohol-related disorders, emphasizing the role of genetic factors in its function.
ADH7 activity may be modulated by pharmacological agents or environmental factors, suggesting potential therapeutic implications and the possibility of targeting ADH7 in treatment strategies.
ADH7 expression and activity can change in response to varying alcohol concentrations or exposure durations, and understanding the molecular mechanisms involved enhances our knowledge of alcohol-related effects.
ADH7 expression is regulated at the transcriptional and post-transcriptional levels by various factors and signaling pathways, providing insights into its regulation.
ADH7 exhibits a tissue-specific expression pattern, which may differ from other ADH isoforms, highlighting its unique role in specific tissues.
Exploring the consequences of ADH7 deficiency or overexpression provides insights into its role in alcohol metabolism and its impact on physiological processes related to alcohol-related disorders.
ADH7 may participate in the metabolism of other endogenous compounds or xenobiotics, suggesting its involvement in broader physiological functions beyond alcohol metabolism.
The enzymatic kinetics and substrate specificity of ADH7 contribute to its function in alcohol metabolism, enabling efficient conversion of specific alcohol substrates.
Investigating the structural features of ADH7 provides valuable information on its catalytic activity and binding properties, aiding in understanding its function.
Customer Reviews (2)
Write a reviewHighly specific in recognizing and binding to target antigens in immunodiagnostic assays.
Exhibits excellent resistance to thermal denaturation in thermal shift assays.
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