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Official Full Name AF4/FMR2 family, member 1
Background Note=A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation t(4;11)(q21;q23) with MLL/HRX. The result is a rogue activator protein.
Synonyms AFF1; AF4/FMR2 family, member 1; AF4; PBM1; MLLT2; AF4/FMR2 family member 1; protein AF-4; proto-oncogene AF4; pre-B-cell monocytic leukemia partner 1; ALL1-fused gene from chromosome 4 protein; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2;
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • E.Coli or Yeast
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AFF1-1732H Recombinant Human AFF1 protein, His & T7-tagged E.coli His/T7
    Human AFF1-26446TH Recombinant Human AFF1 Wheat Germ N/A
    Human AFF1-405H Recombinant Human AFF1 Protein, GST-tagged Wheat Germ GST
    Mouse Aff1-3230M Recombinant Mouse Aff1, His-tagged E.Coli or Yeast His

    AFF1 involved in several pathways and played different roles in them. We selected most pathways AFF1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with AFF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Transcriptional misregulation in cancer TMPRSS2; SPINT1; BCL2A1A; CCNT2; SSX2; HIST1H3F; HIST1H3C; HIST2H3C1; PRCC; HIST2H3A

    AFF1 has several biochemical functions, for example, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AFF1 itself. We selected most functions AFF1 had, and list some proteins which have the same functions with AFF1. You can find most of the proteins on our site.

    Function Related Protein
    transcription factor activity, sequence-specific DNA binding FOXM1; NR2F6B; ZFP27; ZNF192; NFIA; NFYA; NR5A5; ATF6B; AHR; ESR2

    AFF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AFF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AFF1.

    Lu, HS; Li, ZC; et al. AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:E15-E24(2014).
    Cen, H; Leng, RX; et al. Association of AFF1 rs340630 and AFF3 rs10865035 polymorphisms with systemic lupus erythematosus in a Chinese population. IMMUNOGENETICS 64:935-938(2012).

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