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AFF1

  • Official Full Name

    AF4/FMR2 family, member 1

  • Overview

    Note=A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation t(4;11)(q21;q23) with MLL/HRX. The result is a rogue activator protein.
  • Synonyms

    AFF1; AF4/FMR2 family, member 1; AF4; PBM1; MLLT2; AF4/FMR2 family member 1; protein AF-4; proto-oncogene AF4; pre-B-cell monocytic leukemia partner 1; ALL1-fused gene from chromosome 4 protein; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AFF1-405H Recombinant Human AFF1 Protein, GST-tagged Wheat Germ GST
Human AFF1-26446TH Recombinant Human AFF1 Wheat Germ N/A 100 amino acids
Human AFF1-1732H Recombinant Human AFF1 protein, His & T7-tagged E.coli His/T7 Met1~Gly183 (Accession # P51825)
Mouse Aff1-3230M Recombinant Mouse Aff1, His-tagged E.Coli or Yeast His 1216
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AFF1 Related Articles

AFF1 involved in several pathways and played different roles in them. We selected most pathways AFF1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with AFF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Transcriptional misregulation in cancerSMAD1;ETV1;EWSR1;FCGR1A;WNT16;ZBTB17;PRCC;SLC45A3;HHEX

AFF1 has several biochemical functions, for example, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AFF1 itself. We selected most functions AFF1 had, and list some proteins which have the same functions with AFF1. You can find most of the proteins on our site.

Function Related Protein
transcription factor activity, sequence-specific DNA bindingTRP53;GLI2;KAT7;STAT5B;HOXD4A;HOMEZA;TEFB;SIX3;SOX32

AFF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AFF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AFF1.

Lu, HS; Li, ZC; et al. AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:E15-E24(2014).
Cen, H; Leng, RX; et al. Association of AFF1 rs340630 and AFF3 rs10865035 polymorphisms with systemic lupus erythematosus in a Chinese population. IMMUNOGENETICS 64:935-938(2012).
  • Q&As
  • Reviews

Q&As (10)

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Can AFF1 protein be targeted or manipulated to modulate gene expression or disease phenotypes, and what are the potential implications for therapeutic interventions? 11/07/2021

AFF1 protein holds potential as a target for modulating gene expression or disease phenotypes, and further research is needed to explore its implications for therapeutic interventions.

Are there any genetic variations or mutations in the gene encoding AFF1 protein that impact its expression or function, and what are the implications for cellular processes or disease susceptibility? 05/11/2021

Genetic variations or mutations in the gene encoding AFF1 protein may impact its expression or function, influencing cellular processes or disease susceptibility.

How does AFF1 protein contribute to cellular processes such as development, differentiation, or disease progression, and what are the underlying molecular mechanisms? 10/08/2020

AFF1 protein contributes to cellular processes such as development, differentiation, or disease progression, and the underlying molecular mechanisms are currently being investigated.

What experimental techniques or assays have been used to study the functional significance of AFF1 protein, such as chromatin immunoprecipitation, RNA-seq, or gene knockdown approaches? 05/23/2018

Various experimental techniques or assays, such as chromatin immunoprecipitation, RNA-seq, or gene knockdown approaches, have been used to study the functional significance of AFF1 protein.

Are there any known post-translational modifications or regulatory mechanisms that modulate the activity or stability of AFF1 protein? 07/05/2017

Post-translational modifications and regulatory mechanisms may modulate the activity or stability of AFF1 protein.

How does dysregulation or dysfunction of AFF1 protein affect transcriptional regulation, gene expression networks, or disease development? 03/22/2017

Dysregulation or dysfunction of AFF1 protein can affect transcriptional regulation, perturb gene expression networks, and contribute to disease development.

How is the expression of AFF1 protein regulated, and what factors or signaling pathways control its expression? 08/16/2015

The expression of AFF1 protein is regulated by specific factors and signaling pathways.

What is the role of AFF1 protein in gene transcription or chromatin remodeling, and how can its function be investigated experimentally? 05/02/2015

AFF1 protein plays a role in gene transcription or chromatin remodeling, and its function can be investigated using techniques like chromatin immunoprecipitation or gene expression analysis.

What is the subcellular localization of AFF1 protein, and how can it be experimentally determined? 04/25/2015

The subcellular localization of AFF1 protein can be experimentally determined using techniques such as immunofluorescence microscopy or subcellular fractionation.

Does AFF1 protein interact with specific molecules or participate in protein complexes, and what are the functional implications of these interactions? 04/12/2015

AFF1 protein may interact with specific molecules or participate in protein complexes, which have functional implications in cellular processes.

Customer Reviews (3)

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Reviews
12/15/2021

    Investigating protein-protein interactions in cellular senescence for aging-related diseases.

    04/07/2019

      Mapping protein-protein interactions in immune checkpoint regulation for immunotherapy.

      03/18/2017

        Unraveling protein-protein interactions in RNA splicing for gene expression regulation.

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