AFF1
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Official Full Name
AF4/FMR2 family, member 1
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Overview
Note=A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation t(4;11)(q21;q23) with MLL/HRX. The result is a rogue activator protein. -
Synonyms
AFF1; AF4/FMR2 family, member 1; AF4; PBM1; MLLT2; AF4/FMR2 family member 1; protein AF-4; proto-oncogene AF4; pre-B-cell monocytic leukemia partner 1; ALL1-fused gene from chromosome 4 protein; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | AFF1-405H | Recombinant Human AFF1 Protein, GST-tagged | Wheat Germ | GST | ||
Human | AFF1-26446TH | Recombinant Human AFF1 | Wheat Germ | N/A | 100 amino acids | |
Human | AFF1-1732H | Recombinant Human AFF1 protein, His & T7-tagged | E.coli | His/T7 | Met1~Gly183 (Accession # P51825) | |
Mouse | Aff1-3230M | Recombinant Mouse Aff1, His-tagged | E.Coli or Yeast | His | 1216 |
- Involved Pathway
- Protein Function
- Interacting Protein
- AFF1 Related Articles
AFF1 involved in several pathways and played different roles in them. We selected most pathways AFF1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with AFF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Transcriptional misregulation in cancer | SMAD1;ETV1;EWSR1;FCGR1A;WNT16;ZBTB17;PRCC;SLC45A3;HHEX |
AFF1 has several biochemical functions, for example, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AFF1 itself. We selected most functions AFF1 had, and list some proteins which have the same functions with AFF1. You can find most of the proteins on our site.
Function | Related Protein |
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transcription factor activity, sequence-specific DNA binding | TRP53;GLI2;KAT7;STAT5B;HOXD4A;HOMEZA;TEFB;SIX3;SOX32 |
AFF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AFF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AFF1.
- Q&As
- Reviews
Q&As (10)
Ask a questionAFF1 protein holds potential as a target for modulating gene expression or disease phenotypes, and further research is needed to explore its implications for therapeutic interventions.
Genetic variations or mutations in the gene encoding AFF1 protein may impact its expression or function, influencing cellular processes or disease susceptibility.
AFF1 protein contributes to cellular processes such as development, differentiation, or disease progression, and the underlying molecular mechanisms are currently being investigated.
Various experimental techniques or assays, such as chromatin immunoprecipitation, RNA-seq, or gene knockdown approaches, have been used to study the functional significance of AFF1 protein.
Post-translational modifications and regulatory mechanisms may modulate the activity or stability of AFF1 protein.
Dysregulation or dysfunction of AFF1 protein can affect transcriptional regulation, perturb gene expression networks, and contribute to disease development.
The expression of AFF1 protein is regulated by specific factors and signaling pathways.
AFF1 protein plays a role in gene transcription or chromatin remodeling, and its function can be investigated using techniques like chromatin immunoprecipitation or gene expression analysis.
The subcellular localization of AFF1 protein can be experimentally determined using techniques such as immunofluorescence microscopy or subcellular fractionation.
AFF1 protein may interact with specific molecules or participate in protein complexes, which have functional implications in cellular processes.
Customer Reviews (3)
Write a reviewInvestigating protein-protein interactions in cellular senescence for aging-related diseases.
Mapping protein-protein interactions in immune checkpoint regulation for immunotherapy.
Unraveling protein-protein interactions in RNA splicing for gene expression regulation.
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