|Official Full Name||AF4/FMR2 family, member 1|
|Background||Note=A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation t(4;11)(q21;q23) with MLL/HRX. The result is a rogue activator protein.|
|Synonyms||AFF1; AF4/FMR2 family, member 1; AF4; PBM1; MLLT2; AF4/FMR2 family member 1; protein AF-4; proto-oncogene AF4; pre-B-cell monocytic leukemia partner 1; ALL1-fused gene from chromosome 4 protein; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
AFF1 involved in several pathways and played different roles in them. We selected most pathways AFF1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with AFF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Transcriptional misregulation in cancer||TMPRSS2; SPINT1; BCL2A1A; CCNT2; SSX2; HIST1H3F; HIST1H3C; HIST2H3C1; PRCC; HIST2H3A|
AFF1 has several biochemical functions, for example, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AFF1 itself. We selected most functions AFF1 had, and list some proteins which have the same functions with AFF1. You can find most of the proteins on our site.
|transcription factor activity, sequence-specific DNA binding||FOXM1; NR2F6B; ZFP27; ZNF192; NFIA; NFYA; NR5A5; ATF6B; AHR; ESR2|
AFF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AFF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AFF1.