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AKR1A1

  • Official Full Name

    aldo-keto reductase family 1, member A1 (aldehyde reductase)

  • Overview

    This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein.
  • Synonyms

    AKR1A1; aldo-keto reductase family 1, member A1 (aldehyde reductase); alcohol dehydrogenase [NADP(+)]; ALR; DD3; dihydrodiol dehydrogenase 3; aldehyde reductase; alcohol dehydrogenase; aldo-keto reductase family 1 member A1; ARM; ALDR1; MGC1380; MGC12529;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E. coli
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AKR1A1-9530H Recombinant Human AKR1A1, GST-tagged E.coli GST 1-325a.a.
Human AKR1A1-408H Recombinant Human AKR1A1 Protein, GST-tagged Wheat Germ GST
Human AKR1A1-129H Recombinant Human AKR1A1 protein, His-tagged E.coli His 1-325aa
Human AKR1A1-485H Recombinant Human AKR1A1 E.coli N/A
Human AKR1A1-2495H Recombinant Human AKR1A1 protein(Met1-Tyr325), His-tagged E. coli N-His Met1-Tyr325
Human AKR1A1-8932HCL Recombinant Human AKR1A1 293 Cell Lysate HEK293 N/A
Human AKR1A1-5474H Recombinant Human AKR1A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AKR1A1-1360HF Recombinant Full Length Human AKR1A1 Protein, GST-tagged In Vitro Cell Free System GST 325 amino acids
Human AKR1A1-4567H Recombinant Human AKR1A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AKR1A1-626HFL Recombinant Full Length Human AKR1A1 Protein, C-Flag-tagged Mammalian cells Flag
Human AKR1A1-303H Recombinant Human AKR1A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human AKR1A1-303H-B Recombinant Human AKR1A1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Akr1a1-1582M Recombinant Mouse Akr1a1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat AKR1A1-595R Recombinant Rat AKR1A1 Protein Mammalian Cell His
Rat Akr1a1-3259R Recombinant Rat Akr1a1, His-tagged E.Coli or Yeast His 325
Rat AKR1A1-251R-B Recombinant Rat AKR1A1 Protein Pre-coupled Magnetic Beads HEK293
Rat AKR1A1-251R Recombinant Rat AKR1A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque AKR1A1-291R Recombinant Rhesus monkey AKR1A1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque AKR1A1-119R-B Recombinant Rhesus Macaque AKR1A1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque AKR1A1-119R Recombinant Rhesus Macaque AKR1A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken AKR1A1-1677C Recombinant Chicken AKR1A1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AKR1A1 Related Research Area

AKR1A1 involved in several pathways and played different roles in them. We selected most pathways AKR1A1 participated on our site, such as Benzo(a)pyrene metabolism, Biological oxidations, Biosynthesis of antibiotics, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Benzo(a)pyrene metabolismAKR1C2;CYP1B1;CYP3A4;FAM84B;AKR1C4;AKR1A1;CYP1A1
Biological oxidationsCYP11B2;CYP2C19;CYP2C8;COMT;CYP4T8;Sult2a2;PAOX;CYP2J2;ADH8A
Biosynthesis of antibioticsSDS;UAP1L1;AKR1A1;LDHAL6B;DLAT;SDSL;DLST;ECHS1;ACAA2
Catabolism of glucuronate to xylulose-5-phosphateAKR1A1;OXSR1
Degradation of aromatic compoundsADH5;AKR1A1B;AKR1A1A;RGN;AKR1A1
Glutathione conjugationGSTK1;GGT6;GSTO2;AKR1A1;GGTLC1
Glycerolipid metabolismDGAT1;PPAP2A;MBOAT2;Cel;DGKQ;MOGAT1;CELL;ALDH9A1B;ALDH2
Glycolysis / GluconeogenesisHK1;DLAT;LDHBB;PGM2;PFKMB;TPI1;G6PC2;ALDOAA;PDHA1

AKR1A1 has several biochemical functions, for example, L-glucuronate reductase activity, alditol:NADP+ 1-oxidoreductase activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1A1 itself. We selected most functions AKR1A1 had, and list some proteins which have the same functions with AKR1A1. You can find most of the proteins on our site.

Function Related Protein
L-glucuronate reductase activity
alditol:NADP+ 1-oxidoreductase activityAKR1C3;PRKRA;AKR1C2;ADH4;AKR7A5;AKR1B1;Akr1b3;AKR1B7;AKR1C21
electron carrier activityGLRX2;PTGESL;NOX4;CYBA;ASPH;AKR7A3;PRKRA;IDH3B;SDHB
protein bindingRUFY3;SLC38A2;VDAC1;ARHGAP26;RNF41;GSE1;ZFP932;TOR1B;ORC6L

AKR1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1A1.

TERF2IP; TERF1; q8czt6_yerpe; EXOSC4

  • Q&As
  • Reviews

Q&As (12)

Ask a question
What diseases is AKR1A1 protein associated with? 04/08/2023

AKR1A1 protein is involved in many diseases, such as metabolic diseases, tumors, autoimmune diseases, etc.

Can you briefly describe the structure and function of AKR1A1 protein? 03/20/2022

The AKR1A1 protein is a REDOX enzyme capable of reducing and oxidizing a variety of compounds, such as toxins and drugs, to maintain the stability of the internal and external environment of the cell.

In what medical fields are inhibitors of AKR1A1 protein applied? 11/30/2021

AKR1A1 protein inhibitors have been used in the treatment of leukemia, AIDS, diabetes and other diseases.

In what parts or cells of the human body does AKR1A1 protein primarily act? 07/25/2021

This protein mainly plays a role in liver, lung, eye, intestine, kidney, prostate, stomach and other parts and a variety of cells, such as germ cells, neurons, alveolar epithelial cells, liver cells and so on.

What metabolic processes does AKR1A1 protein play an important role in? 05/07/2021

AKR1A1 protein plays an important role in various metabolic processes, such as the metabolism of vitamin A and various hormones.

AKR1A1 protein is closely related to the metabolism of which drugs? 02/28/2021

AKR1A1 protein is associated with the metabolism and toxicity of many drugs, such as phenol, pyruvate, acetaminophen, etc.

Which treatments are associated with AKR1A1 protein expression levels? 12/21/2020

The expression level of AKR1A1 protein is related to the therapeutic effect of certain drugs on diseases.

The high expression of AKR1A1 protein is related to the occurrence and development of which diseases? 12/06/2020

The high expression of AKR1A1 protein is associated with the occurrence and development of many diseases, such as tumors, metabolic diseases, and autoimmune diseases.

Do mutations in AKR1A1 protein cause disease? 09/12/2020

AKR1A1 protein gene mutation has a certain relationship with the occurrence of some diseases, such as tumors, metabolic diseases and so on.

Which cell growth and apoptosis processes does AKR1A1 protein play a role in? 06/25/2019

AKR1A1 protein plays a role in tumor cell growth and apoptosis.

Have any studies found any difference in the expression level of AKR1A1 protein in liver cancer and other tumors? 06/01/2019

The expression level of AKR1A1 in liver cancer cells and other tumor cells is different from that in normal cells and is closely related to the proliferation and metastasis of tumor cells.

How does AKR1A1 function differently from other proteins? 04/11/2019

AKR1A1 protein plays a more prominent role in metabolic reduction than other proteins, and its deposition and expression levels are closely related to the occurrence and development of a variety of diseases.

Customer Reviews (4)

Write a review
Reviews
05/20/2023

    Have high sensitivity and specificity in biosensor preparation.

    05/13/2022

      It promoted cell growth and proliferation.

      04/29/2021

        Good selectivity for specific disease-related targets.

        05/19/2020

          Iinhibitory or killing effect on specific pathogens.

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