AKR1A1
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Official Full Name
aldo-keto reductase family 1, member A1 (aldehyde reductase)
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Overview
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. -
Synonyms
AKR1A1; aldo-keto reductase family 1, member A1 (aldehyde reductase); alcohol dehydrogenase [NADP(+)]; ALR; DD3; dihydrodiol dehydrogenase 3; aldehyde reductase; alcohol dehydrogenase; aldo-keto reductase family 1 member A1; ARM; ALDR1; MGC1380; MGC12529;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
AKR1A1 involved in several pathways and played different roles in them. We selected most pathways AKR1A1 participated on our site, such as Benzo(a)pyrene metabolism, Biological oxidations, Biosynthesis of antibiotics, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Benzo(a)pyrene metabolism | AKR1A1;AKR1C2;CYP1B1;CYP1A1;FAM84B;CYP3A4;AKR1C4 |
| Biological oxidations | CYP2K18;UGT1B3;ABHD10;CYP3C1;CYP19A1;CYP11A1;AS3MT;PRKRA;CYP2J2 |
| Biosynthesis of antibiotics | DLD;CTH;SDS;GLYCTK;DLST;AMDHD2;NME6;AK8;SDSL |
| Catabolism of glucuronate to xylulose-5-phosphate | AKR1A1;OXSR1 |
| Degradation of aromatic compounds | AKR1A1B;AKR1A1A;ADH5;AKR1A1;RGN |
| Glutathione conjugation | GSTK1;GSTO2;GGT6;AKR1A1;GGTLC1 |
| Glycerolipid metabolism | PPAP2B;AGPAT2;DAK;AKR1B1L;LPIN2;DGKZ;PPAP2CB;LCLAT1;AKR1A1A |
| Glycolysis / Gluconeogenesis | GAPDH;LDHC;PDHA1;AKR1A1B;TPI1A;ADPGK;ALDH2;ENO2;LDHAL6B |
AKR1A1 has several biochemical functions, for example, L-glucuronate reductase activity, alditol:NADP+ 1-oxidoreductase activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1A1 itself. We selected most functions AKR1A1 had, and list some proteins which have the same functions with AKR1A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| L-glucuronate reductase activity | |
| alditol:NADP+ 1-oxidoreductase activity | ADH4;PRKRA;AKR1C3;AKR1B7;Akr1b3;AKR7A5;AKR1A1;AKR1B1;AKR1C21 |
| electron carrier activity | NDUFS2;ACADSB;PHGDH;AKR7A2;ACOX3;SDHC;GCDHA;LOXL2;AOX3 |
| protein binding | PAN2;CASP8;POP5;EIF3B;RNF216;PALLD;FLOT2;FAM113A;CCDC50 |
AKR1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1A1.
TERF2IP; TERF1; q8czt6_yerpe; EXOSC4
Research Area
- Reviews
- Q&As
Customer Reviews (4)
Write a reviewHave high sensitivity and specificity in biosensor preparation.
It promoted cell growth and proliferation.
Good selectivity for specific disease-related targets.
Iinhibitory or killing effect on specific pathogens.
Q&As (12)
Ask a questionAKR1A1 protein is involved in many diseases, such as metabolic diseases, tumors, autoimmune diseases, etc.
The AKR1A1 protein is a REDOX enzyme capable of reducing and oxidizing a variety of compounds, such as toxins and drugs, to maintain the stability of the internal and external environment of the cell.
AKR1A1 protein inhibitors have been used in the treatment of leukemia, AIDS, diabetes and other diseases.
This protein mainly plays a role in liver, lung, eye, intestine, kidney, prostate, stomach and other parts and a variety of cells, such as germ cells, neurons, alveolar epithelial cells, liver cells and so on.
AKR1A1 protein plays an important role in various metabolic processes, such as the metabolism of vitamin A and various hormones.
AKR1A1 protein is associated with the metabolism and toxicity of many drugs, such as phenol, pyruvate, acetaminophen, etc.
The expression level of AKR1A1 protein is related to the therapeutic effect of certain drugs on diseases.
The high expression of AKR1A1 protein is associated with the occurrence and development of many diseases, such as tumors, metabolic diseases, and autoimmune diseases.
AKR1A1 protein gene mutation has a certain relationship with the occurrence of some diseases, such as tumors, metabolic diseases and so on.
AKR1A1 protein plays a role in tumor cell growth and apoptosis.
The expression level of AKR1A1 in liver cancer cells and other tumor cells is different from that in normal cells and is closely related to the proliferation and metastasis of tumor cells.
AKR1A1 protein plays a more prominent role in metabolic reduction than other proteins, and its deposition and expression levels are closely related to the occurrence and development of a variety of diseases.
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