AKR7A2
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Official Full Name
aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -
Overview
The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. -
Synonyms
AKR7A2;aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase);aflatoxin B1 aldehyde reductase member 2;AFAR;AFB1-AR 1;SSA reductase;aldoketoreductase 7;AFB1 aldehyde reductase 1;succinic semialdehyde reductase;aflatoxin beta1 alde
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
Involved Pathway
AKR7A2 involved in several pathways and played different roles in them. We selected most pathways AKR7A2 participated on our site, such as Metabolism of xenobiotics by cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR7A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of xenobiotics by cytochrome P | CBR1,UGT5G1,ALDH3B2,UGT1A6A,ALDH3A1,ALDH1A3,GSTM3,GSTT2,UGT1A9,UGT2B15 |
Protein Function
AKR7A2 has several biochemical functions, for example, alditol:NADP+ 1-oxidoreductase activity,electron carrier activity,phenanthrene-9,10-epoxide hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR7A2 itself. We selected most functions AKR7A2 had, and list some proteins which have the same functions with AKR7A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| electron carrier activity | PTGES2,COX5A,GLDC,AOX3,DHDH,ACOXL,ACADVL,AOX1,IDH3B,ME1 |
| alditol:NADP+ 1-oxidoreductase activity | ADH4,AKR1C21,PRKRA,AKR1A1,AKR1B7,AKR1B1,Akr1b3,AKR7A5,AKR1C3,AKR1B8 |
| phenanthrene-9,10-epoxide hydrolase activity | AKR7A5,PRKRA |
Interacting Protein
AKR7A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR7A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR7A2.
HLA-B;AKR7A3;Tpx2;Trp53bp1;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;KATNA1;RALA;PCNA;CCNB1;VCAM1;CDK2;MSH6;C21orf59;Mark2;SMC1A;Prkaa1;Cep131
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