alad Protein, aminolevulinate dehydratase


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Official Full Name aminolevulinate dehydratase
Background The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria.
Synonyms ALAD; aminolevulinate dehydratase; aminolevulinate, delta , dehydratase; delta-aminolevulinic acid dehydratase; ALADH; PBGS; porphobilinogen synthase; MGC5057; OTTMUSP00000009377; RP11-10I9.1; ALADR; Delta aminolevulinic acid dehydratase; Lv; OTTMUSP00000009376; RP24-189G18.9; aminolevulinate, delta-, dehydratase
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ALAD-26880TH Recombinant Human ALAD, His-tagged E.coli His
    Human ALAD-428H Recombinant Human ALAD Protein, GST-tagged Wheat Germ GST
    Human ALAD-512H Recombinant Human ALAD Protein, His-tagged E.coli His
    Human ALAD-54HCL Recombinant Human ALAD cell lysate N/A
    Mouse ALAD-1512M Recombinant Mouse ALAD Protein Mammalian Cell His
    Rat Alad-513R Recombinant Rat Alad Protein, His-tagged E.coli His
    Rat ALAD-609R Recombinant Rat ALAD Protein Mammalian Cell His
    Cynomolgus Monkey ALAD-292C Recombinant Cynomolgus ALAD Protein, His-tagged Mammalian Cell His
    Chicken ALAD-5496C Recombinant Chicken ALAD Mammalian Cell His
    Zebrafish ALAD-2413Z Recombinant Zebrafish ALAD Mammalian Cell His

    alad involved in several pathways and played different roles in them. We selected most pathways alad participated on our site, such as Porphyrin and chlorophyll metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with alad were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Porphyrin and chlorophyll metabolism PPOX; HMBSA; HEPH; UGT2A1; UGT2B7; UGT1A2; UGT1A1; UGT1A6A; P22; EARS2
    Metabolic pathways HADHAB; COASY; URAH; GULO; TCIRG1; ATP6V0CB; GGT5; HPSE; PI4KB; mt-Atp8

    alad has several biochemical functions, for example, catalytic activity, identical protein binding, lead ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by alad itself. We selected most functions alad had, and list some proteins which have the same functions with alad. You can find most of the proteins on our site.

    Function Related Protein
    catalytic activity AOX3; CKMT2B; CKBA; BCHE; AZIN1B; PFKFB4L; DIP2A; SLC3A2A; MED16; CPS1
    identical protein binding JMJD6; GRIN3A; IRF3; DYNLT1B; LEPR; GUCY2E; USP15; STXBP1; MAP3K11; GRB2
    lead ion binding ALAD
    porphobilinogen synthase activity ALAD
    zinc ion binding PPARA; PJA1; NR1H3; PHC2A; UPF1; RBX1; PDZRN4; BMI1A; TRIM67; MDM4

    alad has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with alad here. Most of them are supplied by our site. Hope this information will be useful for your research of alad.

    Alad; 15-deoxy-delta(12,14

    Bardag-Gorce, F; French, SW; et al. Delta-aminolevulinic dehydratase is a proteasome interacting protein. EXPERIMENTAL AND MOLECULAR PATHOLOGY 91:485-489(2011).
    Varadharajan, S; Sagar, BKC; et al. Localization of ferrochelatase in Plasmodium falciparum. BIOCHEMICAL JOURNAL 384:429-436(2004).

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