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AMY1A

  • Official Full Name

    amylase, alpha 1A (salivary)

  • Overview

    Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. Alternative splicing results in multiple transcript variants encoding the same protein.
  • Synonyms

    AMY1A; amylase, alpha 1A (salivary); AMY1, amylase, alpha 1A; salivary; alpha-amylase 1; glycogenase; salivary alpha-amylase; salivary amylase alpha 1A; amylase, salivary, alpha-1A; 1,4-alpha-D-glucan glucanohydrolase 1; AMY1; AMY1B; AMY1C;

  • Recombinant Proteins
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • E.coli
  • HEK293
  • HEK293T
  • Human Saliva
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AMY1A-533H Recombinant Human AMY1A protein, GST-tagged Wheat Germ GST
Human AMY1A-7027H Recombinant Human AMY1A protein, His-tagged E.coli His Ala15~Leu511 (Accession # P04745)
Human AMY1A-726HFL Recombinant Full Length Human AMY1A Protein, C-Flag-tagged Mammalian cells Flag
Human AMY1A-5329H Native Human Amylase, Alpha 1A (salivary) Human Saliva N/A
Human AMY1A-5313H Native Human Amylase, Alpha 1A (salivary) Human Saliva N/A
Human AMY1A-2967H Recombinant Human AMY1A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AMY1A-8023H Native Human Salivary Amylase (Alpha) Human Saliva N/A
Human AMY1A-8022H Native Human Salivary Amylase Human Saliva N/A
Human AMY1A-336H-B Recombinant Human AMY1A Protein Pre-coupled Magnetic Beads HEK293
Human AMY1A-0538H Recombinant Human AMY1A Protein (Ala15-Leu511), His-tagged E.coli His Ala15-Leu511
Human AMY1A-336H Recombinant Human AMY1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken AMY1A-1118C Recombinant Chicken AMY1A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

AMY1A involved in several pathways and played different roles in them. We selected most pathways AMY1A participated on our site, such as Starch and sucrose metabolism, Metabolic pathways, Salivary secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with AMY1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Starch and sucrose metabolismUGT1A6B;Amy1;GYS1;GAA;G6PCA.1;UGT1A1;UGT5G1;AMY2A5;PGM1
Metabolic pathwaysPOLR1C;TRIT1;ALDH6A1;CKMA;HSD3B5;PTDSS2;CKBB;CYP4A10;GALCA
Salivary secretionPLCB4;PRH2;PLCB1;CALML3;MUC5B;CST5;PRKCG;KCNN4;ATP1B3
Carbohydrate digestion and absorptionATP1B1;AMY1A;G6PC3;G6PC2;HKDC1;AMY2B;Amy1;PIK3CG;AKT2

AMY1A has several biochemical functions, for example, alpha-amylase activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AMY1A itself. We selected most functions AMY1A had, and list some proteins which have the same functions with AMY1A. You can find most of the proteins on our site.

Function Related Protein
alpha-amylase activityAMY2A3;Amy1;AMY2B;AMY2A5;AMY1A;AMY1B;AMY2A4;AMY2A2;AMY2A
metal ion bindingIMPDH1;CDH15;ZIC2B;ZNF221;CYP2B19;PHYH;FAM164A;ACO1;Adcy4
protein bindingLRFN2;RERG;CCNG1;CNTROB;SEMA4A;SLC22A2;HDGF2;FLNA;IPO7

AMY1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AMY1A here. Most of them are supplied by our site. Hope this information will be useful for your research of AMY1A.

MUC7; CDK2AP1; SOD2; RASSF6

  • Q&As
  • Reviews

Q&As (13)

Ask a question
Are there any diseases or disorders associated with the AMY1A protein? 03/21/2023

Currently, there are no known diseases or disorders specifically associated with the AMY1A protein itself. However, variations in the AMY1A gene, such as changes in gene copy number, have been studied in relation to certain health conditions. For example, some research suggests that a higher number of AMY1A gene copies may be associated with a reduced risk of obesity and improved glycemic control.

Is the AMY1A gene heritable? 08/26/2022

Yes, the AMY1A gene is heritable. It is passed down from parents to offspring in a Mendelian manner, meaning it follows the principles of inheritance outlined by Gregor Mendel. The number of AMY1A gene copies an individual has can vary among individuals due to genetic variation. This gene copy number variation can be inherited, resulting in some individuals having a higher or lower number of AMY1A gene copies than others.

Are there any variations or mutations in the AMY1A gene that affect its protein function? 04/07/2022

Yes, variations in the AMY1A gene can lead to differences in the number of AMY1A gene copies in an individual's genome. Some people may have a higher number of AMY1A gene copies (high AMY1A copy number), while others may have a lower number (low AMY1A copy number). These variations can impact the production and activity of the AMY1A protein, potentially affecting an individual's ability to digest and metabolize carbohydrates efficiently.

Is the AMY1A protein involved in any other biological processes besides carbohydrate digestion? 08/12/2021

While the primary function of the AMY1A protein is in carbohydrate digestion, there is evidence to suggest that it may have additional roles in other biological processes. Some studies have indicated that salivary amylase, which includes the AMY1A enzyme, might have antimicrobial properties, helping to prevent oral infections.

Can the activity of the AMY1A protein be affected by medications or other substances? 05/12/2021

The activity of the AMY1A protein is not significantly affected by medications or other substances. However, it is worth noting that certain medications or conditions that alter salivary flow or composition may indirectly affect the activity of the AMY1A protein.

Are there any known genetic mutations in the AMY1A gene? 04/02/2021

While genetic mutations in the AMY1A gene have been studied, they are relatively rare. Most of the genetic variability observed in the gene relates to variations in gene copy number rather than specific mutations. However, some studies have identified specific genetic variations, such as single nucleotide polymorphisms (SNPs), in the AMY1A gene that may influence its expression and function. These genetic variations are being investigated to understand their potential impact on carbohydrate metabolism and related health outcomes.

Are there any conditions or factors that can affect the expression or activity of the AMY1A gene? 05/22/2020

Yes, various conditions and factors can influence the expression or activity of the AMY1A gene. Dietary factors, such as the amount and type of carbohydrates consumed, can impact the expression of the AMY1A gene. It has been observed that individuals who consume high-starch diets tend to have higher AMY1A gene copy numbers. Additionally, genetic factors can also play a role. Variations in the AMY1A gene itself, such as changes in gene copy number or specific genetic variations, can affect its expression and activity.

Are there any medical tests available to determine an individual's AMY1A gene copy number? 02/26/2020

Yes, there are laboratory tests available to determine an individual's AMY1A gene copy number. These tests typically involve analyzing the DNA of an individual to identify the number of AMY1A gene copies they possess.

Are there any known interactions between the AMY1A protein and other proteins or enzymes? 02/22/2020

The AMY1A protein primarily functions in carbohydrate digestion in the oral cavity. It breaks down starches into smaller polysaccharides and sugars. While there are no known direct protein-protein interactions between AMY1A and other proteins, it collaborates with other enzymes in the digestive process.

Can variations in AMY1A gene copy number affect an individual's dietary requirements or preferences? 02/28/2019

There is some evidence to suggest that variations in AMY1A gene copy number may have an impact on an individual's dietary requirements or preferences. It has been suggested that individuals with a higher number of AMY1A gene copies may have a greater capacity to digest and metabolize carbohydrates, which might influence their dietary needs. Furthermore, some studies have observed differences in taste perception and preferences for sweet or starchy foods based on AMY1A gene copy number variations.

Is the AMY1A protein associated with any health conditions or diseases? 12/28/2017

The AMY1A protein itself is not directly associated with any health conditions or diseases. However, the variations in AMY1A gene copy number have been linked to certain conditions. For example, individuals with a higher number of AMY1A gene copies may have a more efficient carbohydrate digestion capacity, which has been suggested to be protective against the development of obesity and related metabolic disorders. However, more research is needed to establish the definitive implications of AMY1A gene copy number variations on health outcomes.

How does the AMY1A protein contribute to carbohydrate digestion? 04/19/2017

When food enters the mouth, the AMY1A enzyme is released into the oral cavity via saliva. Once in contact with carbohydrates, it begins breaking down starch molecules into smaller sugar units, initiating the digestion process. The activity of the AMY1A enzyme continues in the stomach until it is denatured by stomach acids. Further digestion of carbohydrates occurs in the small intestine by other enzymes like pancreatic amylase.

How is the production of the AMY1A protein regulated? 05/03/2016

The production of the AMY1A protein is regulated by the expression of the AMY1A gene. The expression of this gene is influenced by various genetic and environmental factors. For instance, the number of AMY1A gene copies an individual possesses can affect the overall level of the AMY1A protein produced.

Customer Reviews (4)

Write a review
Reviews
06/30/2021

    By actively engaging with researchers and understanding their needs, manufacturers can contribute significantly to the success and impact of research involving the AMTN protein.

    01/29/2021

      Manufacturers with the capacity for bulk production can offer AMY1A protein in larger quantities, which is advantageous for researchers working on large-scale experiments or collaborations.

      01/31/2020

        Manufacturers can actively seek collaborations and partnerships with researchers to develop new applications or optimize methodologies using AMY1A protein.

        03/22/2016

          bulk production often leads to economies of scale, making the AMY1A protein more cost-effective for research budgets.

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