Native Human Amylase, Alpha 1A (salivary)
Cat.No. : | AMY1A-5313H |
Product Overview : | Native human AMY1A wasexpressed in Human Saliva. |
- Specification
- Gene Information
- Related Products
Cat. No. : | AMY1A-5313H |
Description : | AMY1A are secretedproteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides andpolysaccharides, and thus catalyze the first step in digestion of dietarystarch and glycogen. The human genome has a cluster of several amylase genesthat are expressed at high levels in either salivary gland (AMY1) or pancreas(AMY2). AMY1A is the isoenzyme produced by the salivary gland. |
Form : | Liquid in a buffercontaining 10 mM Tris-Cl pH7.5. |
Source : | Human Saliva |
Biological Activity : | Typically >2000units/ml |
Concentration : | Typically >5 mgprotein/ml |
Storage : | Store at 2-8oC. |
Pathways : | Carbohydratedigestion and absorption; Digestion of dietary carbohydrate; Metabolicpathways; Metabolism of carbohydrates; Salivary secretion; Starch and sucrosemetabolism |
Gene Name : | AMY1A amylase, alpha 1A(salivary) [ Homo sapiens ] |
Official Symbol : | AMY1A |
Synonyms : | AMY1A; amylase, alpha 1A(salivary); AMY1; AMY1B; AMY1C; alpha-amylase 1; glycogenase;OTTHUMP00000012688; salivary alpha-amylase; salivary amylase alpha 1A;amylase, salivary, alpha-1A; 1,4-alpha-D-glucan glucanohydrolase 1; amylase,alpha 1A; salivary; EC 3.2.1.1 |
Gene ID : | 276 |
mRNA Refseq : | NM_001008221 |
Protein Refseq : | NP_001008222 |
MIM : | 104700 |
UniProt ID : | P04745 |
Chromosome Location : | 1p21 |
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◆ Native Protein | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (13)
Ask a questionCurrently, there are no known diseases or disorders specifically associated with the AMY1A protein itself. However, variations in the AMY1A gene, such as changes in gene copy number, have been studied in relation to certain health conditions. For example, some research suggests that a higher number of AMY1A gene copies may be associated with a reduced risk of obesity and improved glycemic control.
Yes, the AMY1A gene is heritable. It is passed down from parents to offspring in a Mendelian manner, meaning it follows the principles of inheritance outlined by Gregor Mendel. The number of AMY1A gene copies an individual has can vary among individuals due to genetic variation. This gene copy number variation can be inherited, resulting in some individuals having a higher or lower number of AMY1A gene copies than others.
Yes, variations in the AMY1A gene can lead to differences in the number of AMY1A gene copies in an individual's genome. Some people may have a higher number of AMY1A gene copies (high AMY1A copy number), while others may have a lower number (low AMY1A copy number). These variations can impact the production and activity of the AMY1A protein, potentially affecting an individual's ability to digest and metabolize carbohydrates efficiently.
While the primary function of the AMY1A protein is in carbohydrate digestion, there is evidence to suggest that it may have additional roles in other biological processes. Some studies have indicated that salivary amylase, which includes the AMY1A enzyme, might have antimicrobial properties, helping to prevent oral infections.
The activity of the AMY1A protein is not significantly affected by medications or other substances. However, it is worth noting that certain medications or conditions that alter salivary flow or composition may indirectly affect the activity of the AMY1A protein.
While genetic mutations in the AMY1A gene have been studied, they are relatively rare. Most of the genetic variability observed in the gene relates to variations in gene copy number rather than specific mutations. However, some studies have identified specific genetic variations, such as single nucleotide polymorphisms (SNPs), in the AMY1A gene that may influence its expression and function. These genetic variations are being investigated to understand their potential impact on carbohydrate metabolism and related health outcomes.
Yes, various conditions and factors can influence the expression or activity of the AMY1A gene. Dietary factors, such as the amount and type of carbohydrates consumed, can impact the expression of the AMY1A gene. It has been observed that individuals who consume high-starch diets tend to have higher AMY1A gene copy numbers. Additionally, genetic factors can also play a role. Variations in the AMY1A gene itself, such as changes in gene copy number or specific genetic variations, can affect its expression and activity.
Yes, there are laboratory tests available to determine an individual's AMY1A gene copy number. These tests typically involve analyzing the DNA of an individual to identify the number of AMY1A gene copies they possess.
The AMY1A protein primarily functions in carbohydrate digestion in the oral cavity. It breaks down starches into smaller polysaccharides and sugars. While there are no known direct protein-protein interactions between AMY1A and other proteins, it collaborates with other enzymes in the digestive process.
There is some evidence to suggest that variations in AMY1A gene copy number may have an impact on an individual's dietary requirements or preferences. It has been suggested that individuals with a higher number of AMY1A gene copies may have a greater capacity to digest and metabolize carbohydrates, which might influence their dietary needs. Furthermore, some studies have observed differences in taste perception and preferences for sweet or starchy foods based on AMY1A gene copy number variations.
The AMY1A protein itself is not directly associated with any health conditions or diseases. However, the variations in AMY1A gene copy number have been linked to certain conditions. For example, individuals with a higher number of AMY1A gene copies may have a more efficient carbohydrate digestion capacity, which has been suggested to be protective against the development of obesity and related metabolic disorders. However, more research is needed to establish the definitive implications of AMY1A gene copy number variations on health outcomes.
When food enters the mouth, the AMY1A enzyme is released into the oral cavity via saliva. Once in contact with carbohydrates, it begins breaking down starch molecules into smaller sugar units, initiating the digestion process. The activity of the AMY1A enzyme continues in the stomach until it is denatured by stomach acids. Further digestion of carbohydrates occurs in the small intestine by other enzymes like pancreatic amylase.
The production of the AMY1A protein is regulated by the expression of the AMY1A gene. The expression of this gene is influenced by various genetic and environmental factors. For instance, the number of AMY1A gene copies an individual possesses can affect the overall level of the AMY1A protein produced.
Customer Reviews (4)
Write a reviewBy actively engaging with researchers and understanding their needs, manufacturers can contribute significantly to the success and impact of research involving the AMTN protein.
Manufacturers with the capacity for bulk production can offer AMY1A protein in larger quantities, which is advantageous for researchers working on large-scale experiments or collaborations.
Manufacturers can actively seek collaborations and partnerships with researchers to develop new applications or optimize methodologies using AMY1A protein.
bulk production often leads to economies of scale, making the AMY1A protein more cost-effective for research budgets.
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