ANAPC10
-
Official Full Name
anaphase promoting complex subunit 10
-
Overview
ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is;essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the;anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM;123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 (PubMed;11524682)). -
Synonyms
ANAPC10; anaphase promoting complex subunit 10; anaphase-promoting complex subunit 10; APC10; DKFZP564L0562; DOC1; cyclosome subunit 10;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
ANAPC10 involved in several pathways and played different roles in them. We selected most pathways ANAPC10 participated on our site, such as APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANAPC10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
APC-Cdc20 mediated degradation of Nek2A | ANAPC10;NEK2;UBE2C |
APC/C-mediated degradation of cell cycle proteins | PSME3;PSMA8;PSMD9;ANAPC10;CDK2;AURKB;NEK2;PSMD14;PSMD5 |
APC/C:Cdc20 mediated degradation of Cyclin B | UBE2C;ANAPC10 |
APC/C:Cdc20 mediated degradation of Securin | ANAPC10;PSMA8;PSMD14;PSMD5;PSME3;PSMD10;PSMD9;UBE2C |
APC/C:Cdc20 mediated degradation of mitotic proteins | PSMD9;PSMD14;PSMD10;PSMA8;NEK2;PSME3;ANAPC10;PSMD5;UBE2C |
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | PSMD14;PSMD5;ANAPC10;AURKB;PSME3;PSMD9;PSMA8;UBE2C;PSMD10 |
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | PSME3;PSMD10;PSMD5;ANAPC10;NEK2;PSMD9;PSMD14;UBE2C;PSMA8 |
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | PSMD5;PSMD14;PSMD10;UBE2C;ANAPC10;PSME3;PSMA8;NEK2;PSMD9 |
ANAPC10 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ANAPC10 itself. We selected most functions ANAPC10 had, and list some proteins which have the same functions with ANAPC10. You can find most of the proteins on our site.
Function | Related Protein |
---|
ANAPC10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANAPC10 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANAPC10.
CDC16; Cdc23; Cdc16; Cdc26; CDC23; ANAPC16; Cdc20; Bub1b; MAPK8IP2; PTBP3
- Q&As
- Reviews
Q&As (16)
Ask a questionANAPC10 interacts with several other subunits of the APC/C complex, including ANAPC2, ANAPC6, and ANAPC8. It also interacts with additional regulatory proteins such as ANAPC4 and ANAPC11. These interactions are essential for the assembly and activity of the APC/C complex.
ANAPC10 is a highly conserved protein found in virtually all eukaryotic cells, suggesting a fundamental role in cell cycle regulation. Therefore, it is generally expressed in all cell types. However, the expression levels of ANAPC10 may vary depending on the specific tissue or developmental stage.
Deletion or mutation of ANAPC10 can significantly impact the function of the APC/C complex and disrupt cell cycle regulation. This can lead to various cellular abnormalities, including cell cycle arrest, DNA damage accumulation, and chromosome missegregation. Ultimately, it can result in developmental defects, cell death, or the initiation and progression of diseases such as cancer.
Given its critical role in the cell cycle, the APC/C complex, including ANAPC10, has attracted attention as a potential therapeutic target in cancer treatment. Efforts to develop small molecule inhibitors or disruptors of the APC/C complex are currently underway. However, further studies are needed to assess the feasibility and safety of targeting ANAPC10 specifically.
Currently, there is limited information about diseases specifically associated with ANAPC10 mutations. However, various studies have suggested that dysregulation of the APC/C complex, including its subunits like ANAPC10, can contribute to the development and progression of cancer and other diseases. Further research is needed to fully understand the implications of ANAPC10 mutations in specific disorders.
ANAPC10 has been investigated as a potential diagnostic or prognostic marker in certain cancers. Altered expression or mutations in ANAPC10 have been associated with prognosis in colorectal cancer and ovarian cancer. However, further research is required to determine its clinical utility as a reliable marker in disease diagnosis or prognosis.
ANAPC10 does not appear to have any known isoforms or splice variants in humans. It is a highly conserved protein across species, indicating functional and structural importance.
ANAPC10 expression is tightly regulated throughout the cell cycle. Its levels fluctuate during different phases of the cell cycle, being highest in mitosis when the APC/C complex is most active. Regulation of ANAPC10 expression is complex and involves various signaling pathways and transcriptional regulators that respond to changes in cellular conditions and checkpoints.
While ANAPC10 is primarily known for its role in the cell cycle as a subunit of the APC/C complex, emerging research suggests that it may have additional functions beyond cell cycle regulation. Some studies have implicated ANAPC10 in processes such as DNA repair, centrosome duplication, and chromosome stability, indicating its involvement in maintaining genomic integrity.
Currently, there is limited information about the use of ANAPC10 as a biomarker. However, dysregulation of the APC/C complex, including ANAPC10, has been implicated in various types of cancers. Therefore, further research may explore the potential utility of ANAPC10 as a diagnostic or prognostic biomarker in certain malignancies.
Yes, ANAPC10 can be phosphorylated. Phosphorylation is a common post-translational modification that can regulate protein activity, stability, and protein-protein interactions. The specific phosphorylation sites and the role of ANAC10 phosphorylation are still being investigated.
To the best of our knowledge, there are no specific inhibitors or drugs that directly target ANAPC10. However, due to the critical role of the APC/C complex in cell cycle regulation, there is ongoing research and development of compounds that target the APC/C complex as a whole. These compounds aim to disrupt the activity of the APC/C complex, potentially leading to novel cancer therapies.
ANAPC10 and other subunits of the APC/C complex are regulated by multiple mechanisms during the cell cycle. One critical regulation mechanism involves post-translational modifications, such as phosphorylation and ubiquitination, which can affect the stability, activity, and localization of ANAPC10. Additionally, the expression of ANAPC10 can be controlled by various transcription factors and signaling pathways that are activated during different stages of the cell cycle.
ANAPC10 interacts with various proteins to form the APC/C complex. These include other subunits of the APC/C complex such as ANAPC2, ANAPC4, and ANAPC11. Additionally, ANAPC10 can interact with various regulatory proteins and co-factors to ensure proper APC/C function, including APC/C activator proteins such as CDC20 and CDH1.
Dysregulation of the APC/C complex, including ANAPC10, has been implicated in several diseases, particularly in cancer. Mutations or aberrant expression of ANAPC10 and other APC/C subunits have been observed in various malignancies, including colorectal cancer, breast cancer, and ovarian cancer. Additionally, ANAPC10 dysregulation has been linked to developmental disorders and neurodegenerative diseases, although more research is needed to understand these associations fully.
Currently, the primary function of ANAPC10 is associated with the regulation of the cell cycle through the APC/C complex. However, some studies suggest that ANAPC10 may have additional roles in processes such as DNA repair, gene expression, and centrosome replication. Further research is needed to fully understand any potential non-cell cycle-related functions of ANAPC10.
Customer Reviews (5)
Write a reviewThe manufacturer of ANAPC10 protein plays a crucial role in supporting my research efforts.
the manufacturer's commitment to quality control is essential in achieving reliable and consistent outcomes
The manufacturer also offers valuable customer support, actively aiding researchers in their experimental journey.
This guidance allows me to design and implement experiments effectively while adhering to best practices, enhancing the reliability and reproducibility of my results.
They ensure the purity, integrity, and functionality of ANAPC10 protein through rigorous quality control measures.
Ask a Question for All ANAPC10 Products
Required fields are marked with *
My Review for All ANAPC10 Products
Required fields are marked with *