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  • Official Full Name
  • Angiogenin
  • Background
  • Angiogenin (Ang) also known as ribonuclease 5 is a protein that in humans is encoded by the ANG gene. Angiogenin is a potent stimulator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Hooper et al. (2003) reviewed the evidence that angiogenins are involved in host defense and noted that inflammation provokes upregulated ANG mRNA expression in liver and an increase in detectable ANG protein in serum. Weremowicz et al. (1989, 1990) assigned the human angiogenin gene to chromosome 14q11.
  • Synonyms
  • Angiogenin; Ang; ribonuclease 5
Cat.#:ANG-2082HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ANG Protein, MYC/DDK-tagged
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Cat.#:ANG-2629HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Angiogenin, Ribonuclease, RNase A Family, 5
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Cat.#:ANG-507HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human angiogenin, ribonuclease, RNase A family, 5, His-tagged
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Cat.#:ANG-5108HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ANG, His-tagged
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Cat.#:ANG-548HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ANG protein, GST-tagged
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Cat.#:ANG-9641HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ANG, His-tagged
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Cat.#:ANG-1627MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ANG Protein
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Cat.#:Ang-3453MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Ang, His-tagged
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Cat.#:Ang-519MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ang protein, His-tagged
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Cat.#:Ang-520MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ang protein, His & GST-tagged
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Cat.#:Ang-522RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ang protein, His & T7-tagged
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Cat.#:ANG-6811CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ANG
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Cat.#:ANG-518CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle ANG protein, His-tagged
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Cat.#:ANG-521PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig ANG protein, His-tagged
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Cat.#:ANG-20HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ANG lysate
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Involved Pathway

ANG involved in several pathways and played different roles in them. We selected most pathways ANG participated on our site, such as Adherens junctions interactions, Cell junction organization, Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adherens junctions interactions
CDH24; CDH10; CDH9; JUP; PTBP3; CDH12; CDH8; CADM2; CDH3; CDH4
Cell junction organization
RSU1; CDH5; COL17A1A; CLDN3; CDH3; LIMS1; CLDN23; COL17A1; ITGB1B.1; JUP
Cell-Cell communication
CDH4; CLDN23; CADM2B; PVRL1A; PLEC; RSU1; F11R.2; CDH8; CDH12; CDH5
Cell-cell junction organization
CLDN4; CADM2A; INADL; CDH24; JUP; CDH10; CDH9; CLDN3; CDH3; CADM2B

Protein Function

ANG has several biochemical functions, for example, DNA binding, actin binding, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANG itself. We selected most functions ANG had, and list some proteins which have the same functions with ANG. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein NR1D1; NFIX; ISL2B; TBX4; NTNG1; POLDIP2; VDR; HELT; MXTX1; RORA
Function actin binding
Related Protein MKL1; PLEC; AVIL; TPM2; LSP1; WASB; GMFG; PARVAA; SYNE2; FMNL2
Function copper ion binding
Related Protein LOXL1; CUTC; SCO1; SNCA; TP53; MOXD1L; HEPHL1; LOX; F5; LOXL4
Function endonuclease activity
Related Protein SETMAR; EME1; RNASEKA; RNASE6; RNASEKB; ENDOU2; DROSHA; RNASEL4; RNASE3; SMG6
Function heparin binding
Related Protein SLIT3; FMOD; KAL1; THBS4; SMOC2; NOV; PDCD5; POSTN; CXCL13; FGF9
Function peptide binding
Related Protein TPP1; NPFFR2; ERAP2; CTSL2; CMA1; AVPR1B; MME; PLOD1; NPFFR1L1; CRHBP
Function protein binding
Related Protein CAV1; ARL4D; CDK7; TRIM55; DDX3X; ARFGAP1; NIPAL1; EYA3; KRT6C; ATP6V1C2
Function protein homodimerization activity
Related Protein SYT14; CADM3; HSPB6; WWTR1; RQCD1; APOA1BP; TBC1D22A; HEYL; SYT6; CORO1A
Function rRNA binding
Related Protein NOL12; RPS5; MRPL16; ERAL1; RPS4Y2; FASTKD5; RPL11; RPL8; FASTKD2; RNASEL
Function receptor binding
Related Protein C1QTNF2; HAO2; PLA2G1B; YES1; ICOSLG; NPPA; LAMA3; ACOX2; MLN; SLC39A1
Function ribonuclease activity
Related Protein RNASET2B; AZGP1; RNASE7; DIS3L2; ANG3; RNASE6; EAR3; EAR14; RNASE3; RSFR

Interacting Protein

ANG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANG here. Most of them are supplied by our site. Hope this information will be useful for your research of ANG.
ACTN2; FST; RNH1; TDGF1; FST; PTEN; ATP6AP1; ABCG8

ANG Related Articles

Berger, JM; Vaillant, N; et al. PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension. ATHEROSCLEROSIS 239:252-259(2015).
Glenn, DJ; Cardema, MC; et al. Cardiac steatosis potentiates angiotensin II effects in the heart. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 308:H339-H350(2015).