Recombinant Mouse Ang, His-tagged

• Cat.No.: Ang-3453M
• Product Overview: Angiogenin (Ang)

Specification

• Description: This gene encodes a member of the pancreatic ribonuclease A superfamily and is a potent inducer of neovascularization. The encoded protein is a secreted multifunctional tRNA-specific ribonuclease that promotes angiogenesis in response to angiogenetic stimuli such as hypoxia, mediates stress-induced translational repression by cleaving cellular tRNAs, stimulates cell proliferation by mediating rRNA transcription in prostate cancer cells, and is involved in neurite pathfinding. This gene resides in a cluster of highly related genes. It shares dual promoters and 5" exons with the ribonuclease, RNase A family 4 gene. Two alternatively spliced variants, with different 5" exons but the same coding exon, have been identified. Multiple pseudogenes have been found for this gene.
• Source: E. Coli or Yeast
• Species: Mouse
• Tag: His
• Form: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Protein length: 145
• Purity: >90%
• Notes: Small volumes of Ang recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
• Storage Buffer: PBS pH 7.4, 50% glycerol
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Information

• Gene Name: Ang angiogenin, ribonuclease, RNase A family, 5 [ Mus musculus ]
• Official Symbol: Ang
• Synonyms: ANG; angiogenin, ribonuclease, RNase A family, 5; angiogenin; RNase 5; angiogenin-1; ribonuclease 5; angiogenin, ribonuclease A family, member 1; Ang1; Rnase5; Rnase5a; AI385586
• Gene ID: 11727
• mRNA Refseq: NM_001161731
• Protein Refseq: NP_001155203
• Pathway: Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem; Tie2 Signaling, organism-specific biosystem
• Function: RNA binding; actin binding; copper ion binding; endonuclease activity; heparin binding; hydrolase activity; nuclease activity; nucleic acid binding; pancreatic ribonuclease activity; peptide binding; receptor binding; ribonuclease activity; ribonuclease activity