APBA2
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Official Full Name
amyloid beta (A4) precursor protein-binding, family A, member 2
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Overview
Amyloid beta A4 precursor protein-binding family A member 2 (APBA2) is a neuronal adaptor protein that interacts with the amyloid beta precursor protein (APP). The amyloid beta-protein (Abeta), is the principal component of amyloid plaques, a pathological -
Synonyms
APBA2; amyloid beta (A4) precursor protein-binding, family A, member 2; amyloid beta (A4) precursor protein binding, family A, member 2 (X11 like) , MINT2, X11 like , X11L; amyloid beta A4 precursor protein-binding family A member 2; D15S1518E; HsT16821;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian cell
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- Myc
- T7
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
APBA2 involved in several pathways and played different roles in them. We selected most pathways APBA2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with APBA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
APBA2 has several biochemical functions, for example, beta-amyloid binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APBA2 itself. We selected most functions APBA2 had, and list some proteins which have the same functions with APBA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-amyloid binding | ITM2C;APOA1;APBA2;APBB2;BACE1;CD74;APOE;BACE2;APOEA |
| protein binding | DIS3L;RRP8;HPX;MT3;MIS12;SMCO4;ERP44;KLF6;C19orf44 |
APBA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APBA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of APBA2.
CLSTN1; USP20; App; yscK; MAPK6
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (4)
Write a reviewAPBA2 is really amazing, and the results are very consistent every time, you can see that the production process is very careful.
APBA2 they produced has good solubility and can dissolve easily.
After using this recombinant protein, the quantitative accuracy of Western blot was significantly improved.
The catalytic activity of APBA2 is excellent, and it can make tedious chemical reactions simple, and its simplification is to be appreciated.
Q&As (17)
Ask a questionCurrent studies have found that the APBA2 may have a promising application in neurosystem-related diseases such as Alzheimer's disease, Parkinson's disease, and epilepsy.
Recombinant APBA2 protein can be used in drug screening to evaluate the activity and effectiveness of various drug candidates by detecting the binding ability and affinity of different compounds to it.
As a protein regulating neuronal signaling, APBA2 has potential application prospects in the prevention and treatment of nervous system-related diseases, and is also of great significance for the study of the development, function and pathological mechanism of the nervous system.
The efficacy and safety of APBA2 can be evaluated through in vitro and in vivo pharmacological experiments, toxicity tests, clinical studies and other methods.
The APBA2 can promote the connection between neurons and the formation and stability of synapses, and increase the plasticity of synapses.
At present, no relevant studies have reported the specific antigenicity of APBA2 .
Recombinant APBA2 protein can be used as an indicator in neurobehavioral experiments to evaluate learning and memory ability in mice and rats.
The APBA2 can promote the formation and stability of neuronal synapses and strengthen the connections between neurons, thereby protecting neurons from damage.
APBA2 protein can be expressed in cells by molecular cloning technology, and the can be purified.
APBA2 plays an important role in regulating neuronal signaling and synaptic function, so it has potential application prospects in neurosystem-related diseases such as Alzheimer's disease.
The performance of APBA2 protein in clinical and scientific applications can be further optimized and improved by changing its structure, enzymolysis site and affinity.
APBA2 is a key protein regulating nerve cell signal transmission, which can bind to neurotransmitter receptors, promote neurotransmitter signal transmission, increase synaptic plasticity and promote neuronal differentiation and maturation.
The APBA2 is a protein containing multiple domains, and the three-dimensional structure of some of its structures has been analyzed, including the domain where it binds to the transmitter receptor.
Recombinant APBA2 protein has been widely used in experiments of nervous system development, neurodegenerative diseases, synaptic plasticity, drug screening and so on.
Binding quantitative detection of APBA2 can be performed based on in vitro hybridization, molecular crosslinking, biosensor and other technologies.
The recombinant APBA2 protein can bind to the intrinsic domain of neurotransmitter receptors, regulating neurotransmitter signaling and synaptic plasticity.
Recombinant APBA2 protein can be obtained by molecular cloning technology and cell engineering technology.
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