ARF4 Protein


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Official Full Name ADP-ribosylation factor 4
Background This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene.
Synonyms ARF4; ADP-ribosylation factor 4; ADP ribosylation factor 2; ADP ribosylation factor 4; ARF2; ADP-ribosylation factor 2
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • In Vitro Cell Free System
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ARF4-3396H Recombinant Human ADP-Ribosylation Factor 4, His-tagged E.coli His
    Human ARF4-746H Recombinant Human ARF4 protein, GST-tagged Wheat Germ GST
    Human ARF4-9801H Recombinant Human ARF4, GST-tagged E.coli GST
    Mouse ARF4-1840M Recombinant Mouse ARF4 Protein Mammalian Cell His
    Rat Arf4-3208R Recombinant Rat Arf4, His-tagged E.Coli or Yeast His
    Rat ARF4-750R Recombinant Rat ARF4 Protein Mammalian Cell His
    Rhesus Macaque ARF4-379R Recombinant Rhesus monkey ARF4 Protein, His-tagged Mammalian Cell His
    Human ARF4-8758HCL Recombinant Human ARF4 293 Cell Lysate HEK293 N/A
    Human ARF4-1181HF Recombinant Full Length Human ARF4 Protein, GST-tagged In Vitro Cell Free System GST
    Human ARF4-3956H Recombinant Human ARF4 protein, His-tagged E.coli His
    Human ARF4-6329H Recombinant Human ARF4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Arf4-636M Recombinant Mouse Arf4 Protein, MYC/DDK-tagged HEK293T MYC/DDK

    ARF4 involved in several pathways and played different roles in them. We selected most pathways ARF4 participated on our site, such as Assembly of the primary cilium, Cargo trafficking to the periciliary membrane, EGFR1 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Assembly of the primary cilium CEP89; BBS9; ODF2B; TTC30B; TSGA14; EXOC5; PKD2; EXOC8; ARF4; TCP1
    Cargo trafficking to the periciliary membrane BBS5; BBS7; EXOC1; UNC119B; SSTR3; ARF4; TTC8; EXOC3; TCP1; BBS9
    EGFR1 Signaling Pathway ERRFI1; WNK1; ABI1; KRT17; GRB14; ABI1B; DOK2; ZFP259; GRB7; EEF1A1
    ErbB1 downstream signaling CHN2; EGR1; ARF4; MAP3K2; WASF2; ACTR3; EPS8; ACTR2; ABI1; NCKAP1
    Organelle biogenesis and maintenance RP2; RAB3IP; MTRF1L; MRPL42; BBS10; TUFM; PROL1; TCTEX1D2; MKKS; IFT172
    VxPx cargo-targeting to cilium ARF4; PKD2; CNGA2; ARF4A; RAB3IP; CNGA5; PKD1

    ARF4 has several biochemical functions, for example, GTP binding, GTPase activity, epidermal growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARF4 itself. We selected most functions ARF4 had, and list some proteins which have the same functions with ARF4. You can find most of the proteins on our site.

    Function Related Protein
    GTP binding RND3; THG1L; RAB40A; GNAZ; SRPR; DNM1B; REM1; ARL4C; RND3B; EEF2A.1
    GTPase activity GNAO1B; RRAS; RAB27A; GFM2; EEF1A1A; RND2; GNL3L; HRAS; ARL8A; TUBA8L3
    epidermal growth factor receptor binding GRB2; SNX1; RNF126; FAM83B; HBEGF; ARF4; PLSCR1; Fert2; ERBB4; SHC1
    protein binding SMARCA2; ZC3HC1; FBXO11; CASP7; HMGB3; FAM21C; CCDC103; CEP44; EAF2; TBL3

    ARF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARF4.

    SDCBP2; RCHY1; Cdk1; BABAM1; pi3p; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; MYC; ATF2; STK4; SNW1; AGO4

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