Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Mouse ARF4 Protein

Cat.No. : ARF4-1840M
Product Overview : Recombinant Mouse ARF4 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Mouse
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : Arf4 ADP-ribosylation factor 4 [ Mus musculus ]
Official Symbol : ARF4
Gene ID : 11843
mRNA Refseq : NM_007479.3
Protein Refseq : NP_031505.1
MIM :
UniProt ID : P61750

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (14)

Ask a question
How does ARF4 contribute to membrane remodeling processes? 01/18/2023

ARF4 plays a vital role in membrane remodeling events by recruiting various coat proteins, such as COPI and clathrin, to the appropriate membrane domains. This recruitment facilitates membrane curvature and vesicle formation, allowing for the remodeling and trafficking of intracellular membranes.

Are there any specific diseases or disorders associated with mutations or dysregulation of ARF4? 07/28/2022

Currently, there are no specific diseases or disorders directly linked to ARF4 mutations or dysregulation in humans. However, studies have shown that ARF4 dysregulation can contribute to the pathogenesis of certain diseases, such as neurodegenerative disorders like Alzheimer's disease and Huntington's disease, where aberrant vesicle trafficking and protein misfolding are involved.

What are the main research areas currently focused on related to ARF4? 07/21/2022

Current research on ARF4 is focused on understanding its precise molecular mechanisms and its roles in various cellular processes. This includes investigating its interactions with binding partners, its involvement in vesicle trafficking, protein sorting, and membrane dynamics, as well as its contributions to disease pathogenesis, especially in cancer and neurodegenerative disorders.

Are there any small molecule inhibitors or activators of ARF4? 04/03/2022

To my knowledge, there are no specific small molecule inhibitors or activators of ARF4 currently available. However, there have been efforts to develop compounds that modulate ARF family proteins in general for therapeutic purposes. These compounds often target small GTPases in general or specific regulators of ARF proteins rather than directly acting on ARF4 itself.

Does ARF4 have a role in cellular homeostasis or stress response? 04/15/2021

Yes, ARF4 has been implicated in maintaining cellular homeostasis and responding to stress conditions. It participates in the regulation of organelle integrity and protein sorting during cellular stress, ensuring proper cellular function and adaptation to environmental challenges.

What are the specific roles of ARF4 in cancer biology? 05/19/2020

ARF4 has been implicated in various aspects of cancer biology. It plays a role in tumor cell migration and invasion by regulating the trafficking of proteins involved in cell adhesion and cytoskeletal rearrangement. ARF4 also regulates the secretion of growth factors and cytokines, which can promote tumor growth and angiogenesis. Additionally, studies have shown that ARF4 can modulate tumor cell sensitivity to chemotherapy agents, suggesting its involvement in drug resistance mechanisms.

Are there any known binding partners of ARF4? 04/09/2020

Yes, ARF4 can interact with several binding partners, including various coat proteins like AP-1, AP-3, and AP-4, which are involved in vesicle formation and cargo sorting. It can also interact with proteins involved in membrane fusion and tethering, such as SNARE proteins and tethering factors like golgins.

Can ARF4 influence cell migration and adhesion? 01/18/2020

Yes, ARF4 has been implicated in cell migration and adhesion processes. It is involved in the regulation of membrane protrusions at the leading edge of migrating cells, facilitating cell movement. ARF4 also regulates the trafficking and recycling of adhesion molecules, affecting cell adhesion dynamics.

How is ARF4 involved in protein sorting at the Golgi apparatus? 05/17/2019

ARF4 plays a crucial role in protein sorting at the Golgi by recruiting coat protein complexes and regulating the formation of transport vesicles. It helps in the packaging of cargo proteins into specific vesicles for transport to their target compartments within the cell.

Is ARF4 essential for embryonic development? 04/09/2019

Yes, studies in animal models have shown that ARF4 is essential for embryonic development. Complete loss of ARF4 in mice is embryonically lethal, indicating its critical role in fundamental cellular processes required for proper development.

Are there any genetic variants or mutations in the ARF4 gene associated with human diseases? 09/26/2018

Currently, there is limited information on genetic variants or mutations specifically in the ARF4 gene associated with human diseases. However, dysregulation of ARF4 or its related proteins has been linked to disorders such as cancer, neurodegenerative diseases, and various developmental abnormalities.

Can ARF4 be targeted for therapeutic interventions? 08/11/2018

Targeting ARF4 or its associated proteins could have potential therapeutic implications. Modulating ARF4 activity or its specific downstream effectors may help regulate cellular processes affected in various diseases, including cancer, neurodegenerative disorders, and certain genetic diseases associated with vesicle trafficking defects. However, further research is needed to fully understand ARF4's potential as a therapeutic target.

Is ARF4 involved in intracellular signaling pathways? 09/21/2017

Although ARF4's primary role is in vesicular trafficking, it can indirectly influence signaling pathways by regulating the transport and localization of signaling molecules and receptors within the cell. For example, ARF4 has been shown to play a role in the recycling of certain receptors, thus impacting their signaling activity.

Can ARF4 interact with other proteins or regulators? 03/04/2016

Yes, ARF4 can interact with numerous proteins and regulatory factors to carry out its cellular functions. These include various coat protein complexes (e.g., COPI, clathrin), GTPase-activating proteins (GAPs), guanine nucleotide exchange factors (GEFs), and effector proteins involved in vesicular trafficking and membrane dynamics.

Customer Reviews (8)

Write a review
Reviews
09/25/2022

    Whether it be troubleshooting issues, offering experimental guidance, or addressing any concerns, the manufacturer's technical support ensures that researchers have a reliable and knowledgeable resource to rely on.

    03/14/2022

      From recombinant protein production to modification or labeling services, the company is committed to assisting researchers in obtaining the Arg2 protein in the format and specifications required for their particular studies.

      06/04/2021

        the manufacturer understands the importance of customization and can offer tailored solutions to meet specific research needs.

        01/11/2020

          The manufacturer of the ARF4 protein plays a vital role in supporting my trials.

          11/07/2018

            The company provides a dedicated team of experts who are readily available to assist researchers throughout their experimental journey.

            10/03/2018

              the ARF4 protein not only fulfills my experimental requirements but is also backed by excellent technical support, which guarantees a smooth and successful research experience.

              04/12/2017

                Whether I am investigating enzymatic activity, studying protein-protein interactions, or testing its role in signaling pathways, the ARF4 protein consistently performs exceptionally well.

                10/01/2016

                  By using the ARF4 protein in my experiments, I am confident in obtaining accurate and dependable data.

                  Ask a Question for All ARF4 Products

                  Required fields are marked with *

                  My Review for All ARF4 Products

                  Required fields are marked with *

                  0

                  Inquiry Basket

                  cartIcon
                  logo

                  FOLLOW US

                  Terms and Conditions        Privacy Policy

                  Copyright © 2024 Creative BioMart. All Rights Reserved.

                  Contact Us

                  • /

                  Stay Updated on the Latest Bioscience Trends