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ARHGEF11

  • Official Full Name

    Rho guanine nucleotide exchange factor (GEF) 11

  • Overview

    Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.
  • Synonyms

    ARHGEF11; Rho guanine nucleotide exchange factor (GEF) 11; rho guanine nucleotide exchange factor 11; GTRAP48; KIAA0380; PDZ RHOGEF; ARHGB_HUMAN; ARHGEF 11; DKFZp667F1223; Glutamate transporter EAAT4 associated protein 48; GTRAP 48; OTTHUMP00000038716; OTTHUMP00000038717; PDZ-RhoGEF; Rho guanine exchange factor (GEF) 11; RhoA specific guanine nucleotide exchange factor; RhoGEF glutamate transport modulator; RhoA-specific guanine nucleotide exchange factor; glutamate transporter EAAT4-associated protein 48;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARHGEF11-780H Recombinant Human ARHGEF11 protein, GST-tagged Wheat Germ GST
Human ARHGEF11-376H Recombinant Human ARHGEF11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ARHGEF11-884HFL Recombinant Full Length Human ARHGEF11 Protein, C-Flag-tagged Mammalian cells Flag
Human ARHGEF11-2697H Recombinant Human ARHGEF11 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ARHGEF11-376H-B Recombinant Human ARHGEF11 Protein Pre-coupled Magnetic Beads HEK293
Human ARHGEF11-214H Recombinant Human ARHGEF11 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Mouse Arhgef11-1691M Recombinant Mouse Arhgef11 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat ARHGEF11-769R Recombinant Rat ARHGEF11 Protein Mammalian Cell His
Rat ARHGEF11-425R-B Recombinant Rat ARHGEF11 Protein Pre-coupled Magnetic Beads HEK293
Rat ARHGEF11-425R Recombinant Rat ARHGEF11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ARHGEF11-3372Z Recombinant Zebrafish ARHGEF11 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ARHGEF11 Related Articles

ARHGEF11 involved in several pathways and played different roles in them. We selected most pathways ARHGEF11 participated on our site, such as Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Vascular smooth muscle contractionAVPR1B;MAP2K2;CALM3;PRKCA;CACNA1SA;ADCY1A;PRKCBA;CALM1;RAF1A

ARHGEF11 has several biochemical functions, for example, G-protein alpha-subunit binding, Rho guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF11 itself. We selected most functions ARHGEF11 had, and list some proteins which have the same functions with ARHGEF11. You can find most of the proteins on our site.

Function Related Protein
G-protein alpha-subunit bindingRIC8B;RIC8A;LPAR3;HTR2B;DRD1;RGS14;AGTR1A;RIC8;HTR2A
Rho guanyl-nucleotide exchange factor activityARHGEF28;C9orf100;OBSCN;FGD4;NET1;TIAM2;PLEKHG7;QUO;ITSN1
guanyl-nucleotide exchange factor activityPRSS56;DOCK1;NET1;PREX1;KNDC1;RPGR;ARHGEF18;VAV3B;DOCK4B

ARHGEF11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF11 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF11.

Gawlak, G; Tian, YF; et al. Paxillin mediates stretch-induced Rho signaling and endothelial permeability via assembly of paxillin-p42/44MAPK-GEF-H1 complex. FASEB JOURNAL 28:3249-3260(2014).
Martin, E; Harel, S; et al. pix-1 Controls Early Elongation in Parallel with mel-11 and let-502 in Caenorhabditis elegans. PLOS ONE 9:-(2014).
  • Q&As
  • Reviews

Q&As (12)

Ask a question
What domains or motifs does ARHGEF11 contain? 08/05/2022

ARHGEF11 consists of several functional domains and motifs. It possesses an N-terminal PDZ (PSD-95/Dlg/ZO-1) domain, which is involved in protein-protein interactions and allows ARHGEF11 to interact with other proteins and signaling complexes. Additionally, it contains a Dbl homology (DH) domain responsible for its guanine nucleotide exchange activity, as well as a C-terminal Pleckstrin Homology (PH) domain involved in membrane localization and binding to lipid molecules.

Is ARHGEF11 differentially expressed in specific tissues? 09/21/2021

ARHGEF11 exhibits a broad expression pattern across multiple tissues and cell types. It is often found to be expressed in the brain, heart, kidney, lung, and skeletal muscle, suggesting its involvement in various physiological processes. However, the precise tissue-specific expression profile might vary depending on the developmental stage and specific conditions.

Are there any diseases or disorders directly associated with ARHGEF11? 03/20/2020

While ARHGEF11 has not been directly linked to specific diseases or disorders, dysregulation of its activity or expression has been implicated in various pathological conditions. For example, altered expression of ARHGEF11 has been observed in certain types of cancer, cardiovascular diseases, and neurodevelopmental disorders. Further research is required to fully elucidate the direct involvement of ARHGEF11 in these diseases and explore its potential as a therapeutic target.

Are there any known signaling pathways in which ARHGEF11 is involved? 01/02/2020

Yes, ARHGEF11 is known to be involved in several signaling pathways. One of the main pathways is the Rho GTPase signaling pathway, where ARHGEF11 acts as a guanine nucleotide exchange factor (GEF) for RhoA, promoting its activation. This pathway regulates various cellular processes, including actin cytoskeleton organization, cell migration, and cell adhesion. ARHGEF11 has also been found to interact with other signaling molecules, such as Gα12/13 subunits, suggesting its involvement in G protein-coupled receptor signaling. Additionally, ARHGEF11 has been implicated in the PI3K/AKT signaling pathway, which plays a role in cell survival, growth, and proliferation.

Are there any known functional studies of ARHGEF11 in cellular or animal models? 07/21/2019

Yes, ARHGEF11 has been extensively studied in cellular and animal models. Functional studies have demonstrated its role in regulating Rho GTPase signaling pathways, which impact processes like cell migration, cell polarity, and neuronal development. ARHGEF11 knockout or knockdown experiments have revealed effects on cell morphology and migration, validating its functional role in these processes.

Can ARHGEF11 be targeted for therapeutic purposes? 06/25/2019

Targeting ARHGEF11 for therapeutic purposes is an area of active research. Given its involvement in cancer progression and metastasis, modulation of ARHGEF11 activity or its downstream signaling pathways is being explored as a potential therapeutic strategy. Small molecules or inhibitory peptides that specifically target the GEF activity of ARHGEF11 are being investigated. Additionally, other approaches, such as gene therapy or RNA interference, may be utilized to regulate ARHGEF11 expression or activity in specific diseases or disorders. However, it is important to note that more research is needed to fully understand the therapeutic potential, safety, and efficacy of targeting ARHGEF11 in clinical settings.

Are there any known interaction partners of ARHGEF11? 05/03/2019

ARHGEF11 interacts with various proteins to regulate its signaling functions. Notably, it can interact with Gα12/13 subunits, forming a GPCR-RhoGEF-Gα12/13 signaling complex. ARHGEF11 can also interact with the scaffolding protein paxillin via its PDZ domain, creating a link between Rho signaling and integrin-mediated cellular processes.

Is ARHGEF11 conserved across different species? 12/01/2018

Yes, ARHGEF11 shows conservation across different species, ranging from mammals to birds, reptiles, amphibians, and fish. Its sequence is relatively well-conserved, particularly within the functional domains, suggesting its conserved function in cellular processes throughout evolution.

Are there any therapeutic implications of ARHGEF11? 05/06/2017

The involvement of ARHGEF11 in various cellular processes and its role in cancer progression make it an attractive therapeutic target. Modulating ARHGEF11 activity or its downstream signaling pathways may have potential therapeutic implications in disorders related to abnormal cell migration, such as certain cancers and neurodevelopmental disorders. However, further research is needed to fully understand the therapeutic potential and develop specific strategies targeting ARHGEF11.

Does ARHGEF11 play a role in cancer? 02/09/2017

Yes, ARHGEF11 has been implicated in cancer progression and metastasis. It is known to regulate cellular processes involved in metastasis, such as cell migration, invasion, and epithelial-mesenchymal transition (EMT). Dysregulation of ARHGEF11 expression or activity can contribute to the invasive and migratory properties of cancer cells. Therefore, targeting ARHGEF11 or its downstream signaling pathways may have therapeutic potential for cancer treatment.

Does ARHGEF11 have any known orthologs or paralogs? 09/04/2016

ARHGEF11 has a closely related paralog called ARHGEF12, also known as GEF-H1 or Lfc. ARHGEF12 shares similar domain architecture and functions as a Rho GEF. While ARHGEF11 primarily activates RhoA, ARHGEF12 has a broader specificity and can activate multiple Rho GTPases. The existence of these paralogs allows for functional diversity and regulation within the Rho signaling pathway.

Are there any known genetic variants or mutations in the ARHGEF11 gene? 05/26/2016

Yes, genetic variants and mutations have been identified in the ARHGEF11 gene. Some of these variants have been associated with specific diseases or conditions, such as cardiovascular disorders, neurodevelopmental disorders, and certain cancers. These variants can affect the function or expression of ARHGEF11, leading to altered signaling pathways and cellular processes.

Customer Reviews (8)

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Reviews
12/24/2022

    The technical support provided by the manufacturer is invaluable in overcoming experimental hurdles and optimizing the utilization of ARHGEF11 protein.

    11/09/2020

      In addition to providing impeccable protein quality, the manufacturer offers excellent technical support that can effectively address any challenges I may encounter during my research.

      09/10/2020

        Another crucial aspect where the manufacturer excels is their efficient supply chain management.

        12/13/2018

          The ARHGEF11 protein offered by the manufacturer is of exceptional quality, making it an ideal choice to fulfill my experimental needs.

          09/18/2018

            It demonstrates excellent performance in ELISA assays, making it an ideal choice for researchers studying protein-protein interactions, antibody detection, or biomarker identification.

            12/05/2017

              It enables researchers to delve deeper into the intricacies of protein behavior and aids in advancing our knowledge in various fields, such as molecular biology, biochemistry, and structural biology.

              07/24/2017

                ARHGEF11 protein's remarkable performance in ELISA and protein electron microscopy structure analysis positions it as a valuable tool in various fields, including cardiovascular research, developmental biology, and molecular medicine.

                01/30/2017

                  ARHGEF11 protein's utility in protein electron microscopy structure analysis is commendable.

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