ARL6IP1
-
Official Full Name
ADP-ribosylation factor-like 6 interacting protein 1
-
Overview
ADP-ribosylation factor-like protein 6-interacting protein 1 is a protein that in humans is encoded by the ARL6IP1 gene. -
Synonyms
ARL6IP1; ADP-ribosylation factor-like 6 interacting protein 1; ADP ribosylation factor like 6 interacting protein , ARL6IP; ADP-ribosylation factor-like protein 6-interacting protein 1; AIP1; ARMER; KIAA0069; aip-1; ARL-6-interacting protein 1; apoptotic;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ARL6IP1 Related Articles
ARL6IP1 involved in several pathways and played different roles in them. We selected most pathways ARL6IP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ARL6IP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
ARL6IP1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARL6IP1 itself. We selected most functions ARL6IP1 had, and list some proteins which have the same functions with ARL6IP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CRLF3;DCDC2B;TBC1D14;UBL5;UBR4;MMACHC;SIP1;SDCBP;FRMPD1 |
ARL6IP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARL6IP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARL6IP1.
SNX1; ACSF2; FXR2; e5ks60_human; 346157; SNX3
- Q&As
- Reviews
Q&As (10)
Ask a questionDysregulation of ARL6IP1 can lead to defects in primary cilia formation and function, which have been associated with various human diseases known as ciliopathies. These include Bardet-Biedl syndrome (BBS), Joubert syndrome (JBTS), Meckel syndrome, and others. In these conditions, mutations or loss of function in genes encoding ciliary proteins, including ARL6IP1, can result in developmental abnormalities and organ dysfunction.
The therapeutic potential of targeting ARL6IP1 is not well established yet. However, since primary cilia dysfunction has been associated with various diseases, understanding the role of ARL6IP1 in ciliary biology may provide insights into potential therapeutic interventions for ciliopathies and related disorders.
Dysfunction of primary cilia in the retina has been associated with certain retinal degenerative diseases, including retinitis pigmentosa. Since ARL6IP1 is an important player in primary cilia formation and maintenance, alterations in its expression or function can contribute to these conditions by disrupting the normal signaling and trafficking processes in retinal cells.
The expression of ARL6IP1 is not strictly tissue-specific but shows variations across different cell types and tissues. It is widely expressed in various organs and cell types, with higher expression observed in tissues rich in primary cilia, such as the retina, kidney, and brain. However, it is also expressed in non-ciliated cells, suggesting additional functions beyond ciliary biology.
ARL6IP1 is an essential component for the formation and maintenance of primary cilia. It functions as a linker between the centrosome and the ciliary membrane, facilitating the transport of proteins required for ciliary assembly and signaling. Loss or dysfunction of ARL6IP1 can disrupt primary cilia formation, leading to various developmental and cellular abnormalities.
Yes, ARL6IP1 has been shown to interact with several proteins. These include ARL6, BBSome proteins (BBS1, BBS4, BBS5, and BBS8), MKS1 (Meckel syndrome type 1 protein), NPHP3 (nephrocystin-3), and PCM1 (pericentriolar material 1), among others. These interactions are important for its proper function in primary cilia biology.
Yes, several animal models have been used to investigate the function of ARL6IP1. These include knockout mice lacking the Arl6ip1 gene, zebrafish models with Arl6ip1 depletion, and other genetically modified organisms. These models help researchers understand the role of ARL6IP1 in embryonic development, cilia formation, and associated diseases.
Yes, ARL6IP1 can interact with several proteins involved in cilia formation and function. It has been shown to interact with the small GTPase ARL6, BBSome proteins, and other ciliary trafficking factors. These interactions are important for the proper localization and function of ARL6IP1.
While ARL6IP1 is primarily known for its roles in primary cilia biology, emerging evidence suggests that it may have additional functions. It has been implicated in Golgi organization and vesicular trafficking pathways unrelated to cilia. Further research is needed to fully understand the extent of ARL6IP1's functional contributions in various cellular processes.
Currently, there are no known genetic disorders specifically associated with ARL6IP1 mutations. However, alterations in primary cilia function, which can result from dysregulation of ARL6IP1, are associated with ciliopathies such as Bardet-Biedl syndrome (BBS) and Joubert syndrome (JBTS).
Customer Reviews (10)
Write a reviewThey have a deep understanding of the ARL6IP1 protein and can provide valuable insights into its characteristics, properties, and optimal experimental conditions.
Using ARL6IP1 protein in trials provides advantages such as its involvement in cellular processes and its disease associations.
Manufacturers can enhance the research process by providing high-quality ARL6IP1 protein, technical support, customization options, and potentially collaborative opportunities.
the manufacturer offers outstanding technical support, serving as a valuable resource to resolve any issues that may arise during my research.
This guidance can help researchers design and execute their experiments more effectively, ensuring reliable and accurate results.
The manufacturer's support can play a crucial role in assisting researchers throughout their trials.
Its reliability and applicability make it an invaluable tool for investigating ARL6IP1 protein's expression, function, and structural characteristics.
The high-quality ARL6IP1 protein available from manufacturers ensures consistent and reproducible results in WB experiments, making it an essential tool for researchers studying ANO2-related pathways and biological processes.
Their knowledgeable support team is well-equipped to address specific inquiries, suggest experimental protocols, and provide guidance throughout the entire research process.
A manufacturer can serve as a collaborative partner, engaging in discussions, and exchanging knowledge with researchers.
Ask a Question for All ARL6IP1 Products
Required fields are marked with *
My Review for All ARL6IP1 Products
Required fields are marked with *
