ARRB2
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Official Full Name
arrestin, beta 2
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Overview
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012] -
Synonyms
ARRB2; arrestin, beta 2; ARB2; ARR2; BARR2; beta-arrestin-2; arrestin 3; arrestin beta-2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Rat
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- N/A
- N
- Tag Free
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | ARRB2-9893H | Recombinant Human ARRB2, GST-tagged | E.coli | GST | 162-408a.a. | |
Human | ARRB2-855H | Recombinant Human ARRB2 protein, GST-tagged | Wheat Germ | GST | ||
Human | ARRB2-26621TH | Recombinant Human ARRB2 | Wheat Germ | N/A | 110 amino acids | |
Human | ARRb2-3639H | Recombinant Human ARRb2 protein(Asp262~Cys430), His-GST-tagged | E.coli | N-His-GST | Asp262~Cys430 | |
Human | ARRB2-130HCL | Recombinant Human ARRB2 cell lysate | N/A | |||
Human | ARRB2-0340H | Recombinant Human ARRB2 Protein (Met1-Cys409), C-His-tagged | E.coli | C-His | Met1-Cys409 | |
Human | ARRB2-0341H | Recombinant Human ARRB2 Protein, Tag Free | E.coli | Tag Free | ||
Human | ARRB2-1247HF | Recombinant Full Length Human ARRB2 Protein, GST-tagged | In Vitro Cell Free System | GST | 409 amino acids | |
Rat | ARRB2-803R | Recombinant Rat ARRB2 Protein | Mammalian Cell | His | ||
Rat | ARRB2-459R-B | Recombinant Rat ARRB2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | ARRB2-459R | Recombinant Rat ARRB2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
- Involved Pathway
- Protein Function
- Interacting Protein
- ARRB2 Related Research Area
- ARRB2 Related Signal Pathway
ARRB2 involved in several pathways and played different roles in them. We selected most pathways ARRB2 participated on our site, such as MAPK signaling pathway, Chemokine signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARRB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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MAPK signaling pathway | PPP3CA;HSP70L;C11orf52;HSPA1A;PPM1BB;TRAF6;RAP1B;PDGFA;TGFBR2 |
Chemokine signaling pathway | CXCL12;CXCL8;PRKACA;RELA;CXCR5;RAP1B;PRKACB;ARRB2;GNG11 |
Endocytosis | RAB11BA;RLN1;DNM1B;ZFP652;SNX1A;CHMP6;EPN2;ARPC5A;MVB12BA |
Dopaminergic synapse | GRIN2B;CALM3;CAMK2A;COMT;CALM1;PLCB2;GNG5;PPP2R5B;CAMK2B |
Olfactory transduction | CALML3;OR10C1;PDC;GNB1;OR11A1;OR10W1;SLC8A2;PRKG2;OR2C1 |
ARRB2 has several biochemical functions, for example, 14-3-3 protein binding, D1 dopamine receptor binding, G-protein coupled receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARRB2 itself. We selected most functions ARRB2 had, and list some proteins which have the same functions with ARRB2. You can find most of the proteins on our site.
Function | Related Protein |
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14-3-3 protein binding | TSC2;IRS2;RPTOR;YWHAQ;PRKCE;PPP1R12A;KIF13B;DDIT4;HDAC7 |
D1 dopamine receptor binding | GNAS;DRD3;ARRB2;CAV2;PTPN11;ATP1A3;AGTR1A;DLG4 |
G-protein coupled receptor binding | ARHGEF12;GNA13A;USP33;UCN3;HSPA1B;HSPA8;GNA15.4;PACRG;FCN1 |
alpha-1A adrenergic receptor binding | ARRB2;ARRB1 |
alpha-1B adrenergic receptor binding | ARRB1;ARRB2;ADRA2A |
angiotensin receptor binding | ARRB2;ARRB1;DRD1;DRD1A |
enzyme binding | PRKCE;CYP2C19;SPDL1;RPA3;THRB;PARK7;BCR;N4BP2L2;CBS |
follicle-stimulating hormone receptor binding | ARRB2;ARRB1 |
low-density lipoprotein particle receptor binding | MMP13;LDLRAP1;SACS;AP2M1;APOA5;CRP;SNX17;DKK1;SYT1 |
mitogen-activated protein kinase binding | TNIP1;SIRT1;MAPK7;ATF7;MAPKAPK2A;CDK5RAP3;NBR1;MAPKAPK2B;MAPKAPK5 |
protein binding | TRDN;ATG13;INPP5D;C18orf56;ELL;PARVG;NADK;NUDT21;FANCI |
protein complex binding | Cel;CCND1;SLC25A3;C8G;IST1;PTK2B;UGT1A6B;TUBB;DRD1 |
protein complex scaffold | AKAP1;AKAP9;ITSN1;AXIN1;AKAP6;GNB2L1;SEPT2;SLC9A3R1;HOMER1 |
protein domain specific binding | ST13;WHRN;SCAF1;HIST1H4A;CNTROB;HIST1H4H;TACC2;TH;RAB27A |
receptor binding | WNT2BA;Fert2;FGF18A;FGF8B;FKBP1B;AGXT;EDA;PPY;IFNL3 |
type 1 angiotensin receptor binding | ARRB2;GNA13B;AGT;GNG3;GNB1;TYK2;JAK2;ARAP1;GNA13 |
type 2A serotonin receptor binding | ARRB2;GNA11;GNAQ |
ubiquitin protein ligase binding | RALB;HM13;GRIK2;UBE2KA;SLC25A5;LC3;RIPK1;RPA3;UBE2R2 |
ARRB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARRB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARRB2.
MDM2; MAPK9; ARRB1; PPM1B
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, ARRB2 can interact with a variety of proteins to regulate GPCR signaling and participate in other cellular processes. It can interact with phosphorylated GPCRs to promote desensitization and internalization. ARRB2 also interacts with components of the endocytic machinery, such as clathrin and adaptor proteins, to facilitate receptor internalization. Additionally, ARRB2 can interact with downstream effectors, including kinases and scaffolding proteins, to mediate specific signaling events.
Yes, studies have suggested that ARRB2 can have non-canonical functions independent of GPCR signaling. For instance, ARRB2 has been implicated in regulating cell migration, cell cycle progression, and apoptosis. It can also interact with and modulate the activity of various non-GPCR proteins, including ion channels, tyrosine kinase receptors, and cytoskeletal components. These non-canonical functions of ARRB2 expand its role beyond GPCR regulation.
Given its involvement in neurological and psychiatric disorders, there is ongoing research to explore the therapeutic potential of targeting ARRB2. Scientists are investigating the development of drugs that could modulate ARRB2 function, aiming to restore or enhance its normal signaling activity. Moreover, understanding the specific GPCRs and signaling pathways regulated by ARRB2 could help identify novel targets for therapeutic intervention in relevant diseases.
Yes, genetic variations in the ARRB2 gene have been identified. Some single nucleotide polymorphisms (SNPs) in the ARRB2 gene have been associated with certain psychiatric disorders, like schizophrenia and bipolar disorder. These genetic variations may impact ARRB2 expression or function, potentially contributing to disease susceptibility or clinical phenotypes.
Dysregulation of ARRB2 has been linked to various neurological and psychiatric disorders. For example, alterations in ARRB2 expression and signaling have been observed in schizophrenia, bipolar disorder, and opioid addiction. These findings suggest that ARRB2 dysfunction may contribute to the pathogenesis of these conditions, making it a potential therapeutic target.
Customer Reviews (3)
Write a reviewthe ARRB2 protein has proven to be an invaluable tool in protein electron microscopy structure analysis.
Its exceptional reliability and compatibility with various research methodologies make it an invaluable asset for scientists seeking to delve into protein-protein interactions, signaling pathways, and structural investigations.
Its robust nature and stability make it suitable for imaging studies, providing researchers with a detailed understanding of the protein's structural characteristics.
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