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Official Full Name activating transcription factor 3
Background Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.
Synonyms ATF3; activating transcription factor 3; cyclic AMP-dependent transcription factor ATF-3; cAMP-dependent transcription factor ATF-3; FLJ41705
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • HIS
    • SUMO
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ATF3-064H Recombinant Human ATF3 Protein, GST-HIS-tagged Sf9 Insect Cell GST/His
    Human ATF3-065H Recombinant Human ATF3 Protein, GST-tagged E.coli GST
    Human ATF3-066H Recombinant Human ATF3 Protein, HIS-tagged E.coli HIS
    Human ATF3-23H Recombinant Human ATF3 protein, His-SUMO-tagged E.coli His/SUMO
    Human ATF3-3593H Recombinant Human ATF3 E.coli N/A
    Human ATF3-525H Recombinant Human ATF3 Protein, His/GST-tagged E.coli His/GST
    Human ATF3-8631HCL Recombinant Human ATF3 293 Cell Lysate HEK293 N/A
    Human ATF3-938H Recombinant Human ATF3 protein, GST-tagged Wheat Germ GST
    Mouse Atf3-526M Recombinant Mouse Atf3 Protein, His/GST-tagged E.coli His/GST
    Rat ATF3-839R Recombinant Rat ATF3 Protein Mammalian Cell His
    Rhesus Macaque ATF3-437R Recombinant Rhesus monkey ATF3 Protein, His-tagged Mammalian Cell His
    Zebrafish ATF3-11199Z Recombinant Zebrafish ATF3 Mammalian Cell His

    atf3 involved in several pathways and played different roles in them. We selected most pathways atf3 participated on our site, such as HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with atf3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    atf3 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by atf3 itself. We selected most functions atf3 had, and list some proteins which have the same functions with atf3. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding PAX8; MAX; NR6A1; GMEB2; KCNA3; NFATC3; JDP2; ZNF92; DLX4; ZIC3
    RNA polymerase II regulatory region sequence-specific DNA binding NHLH1; PLAGL1; ZFAT; ATF1; CREB3; TFAP2D; GATA3; PHF21B; AIRE; ZBTB4
    identical protein binding PFKM; GRB2; PLN; P2RX2; SYT9; GOT1; BCAT1; STAT2; HAPLN2; DYNLT1A
    protein binding RALBP1; GSE1; ASIC1; COMMD3; KCNH7; PPP1R12B; GABARAPL2; RBMY1F; MASP1; MC4R
    protein heterodimerization activity BHLHE40; DRAP1; NTSR1; PPP2R1A; IKZF4; RARA; CHRNA3; OSTB; UGT1A9; CHRAC1
    protein homodimerization activity DMRT2B; C16orf89; CREB3L3; HNF4A; GTF2A2; CASQ2; SMAD2; RPS19; CTSE; PDGFC
    transcription corepressor activity PSMC3; TRIB3; SKIL; SUFU; GMNN; RBFOX2; SKOR1A; ZBTB32; ZNF136; SMYD1
    transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding SFPI1; IRF7; FOSL1; RBPJL; CREB3; MSX1; SREBF1; MSX2; BATF2; SNAI3
    transcription factor activity, sequence-specific DNA binding E2F8; POU5F2; TRERF1; SOX7; FOXN3; NR1D2B; KDM5A; EOMESA; NFE2L2B; ZNF43
    transcription regulatory region DNA binding TAF9; ZFP382; FOXH1; H2AFY; HMGB2; HDAC1; GATA4; AHR; TCF7; NR1D1
    transcription regulatory region sequence-specific DNA binding EPAS1B; KDM3A; SUV39H2; ATF3; PSPC1; POU5F1; ARNTL1A; DDIT3; MEF2CA; MEF2AA
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding CTCF; MAFA; ALX1; STAG2; GATA5; MSX1; AIRE; REST; CREBBP; NKX2-5
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding NKX6-1; ZBTB7A; GATA3; BCL11AA; E2F8; IFI203; ATF7; IFI16; OVOL1; KCNIP3

    atf3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with atf3 here. Most of them are supplied by our site. Hope this information will be useful for your research of atf3.


    Al-Bahrani, R; Tuertcher, D; et al. Differential SIRT1 Expression in Hepatocellular Carcinomas and Cholangiocarcinoma of the Liver. ANNALS OF CLINICAL AND LABORATORY SCIENCE 45:3-9(2015).
    Felizola, SJA; Nakamura, Y; et al. Activating Transcription Factor 3 (ATF3) in the Human Adrenal Cortex: Its Possible Involvement in Aldosterone Biosynthesis. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 234:249-254(2014).

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