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Official Full Name activating transcription factor 6 beta
Background The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms ATF6B; activating transcription factor 6 beta; cAMP responsive element binding protein like 1 , CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta; G13; G13 protein; ATF 6 beta; ATF6-beta; ATF6B_HUMAN; ATF6beta; cAMP response element binding protein related protein; cAMP response element-binding protein-related protein; cAMP responsive element binding protein like 1; cAMP-dependent transcription factor ATF-6 beta; cAMP-responsive element-binding protein-like 1; CREB L1; Creb related protein; CREB RP; Creb-rp; CREBL 1; CREBL1; Crebrp; Cyclic AMP dependent transcription factor ATF 6 beta; Cyclic AMP dependent transcription factor ATF6 beta; FLJ10066; OTTHUMP00000029432; OTTHUMP00000029433; Processed cyclic AMP-dependent transcription factor ATF-6 beta; Protein G13; Creb-related protein; cAMP responsive element binding protein-like 1
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ATF6B-26100TH Recombinant Human ATF6B Protein, GST-tagged Wheat Germ GST
    Human ATF6B-26189TH Recombinant Human ATF6B Wheat Germ N/A
    Human ATF6B-9965H Recombinant Human ATF6B, GST-tagged E.coli GST
    Mouse ATF6B-2070M Recombinant Mouse ATF6B Protein Mammalian Cell His
    Zebrafish ATF6B-4821Z Recombinant Zebrafish ATF6B Mammalian Cell His

    atf6b involved in several pathways and played different roles in them. We selected most pathways atf6b participated on our site, such as Adrenergic signaling in cardiomyocytes, Alcoholism, Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with atf6b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adrenergic signaling in cardiomyocytes PIK3CA; PLCB4; PPP2R2D; PPP2R5EB; ATP2B1; MAPK13; Adcy4; CACNB1; PPP1CAA; ADRA1BB
    Aldosterone synthesis and secretion KCNK9; AGTR1; PLCB1; CREB3L2; CALM3; NR4A2; AGTR1A; CALML5; ATF6B; PRKACA
    Amphetamine addiction PRKCA; PDYN; PRKCB; ATF2; PPP3CA; DRD1A; CAMK2B; CAMK2D; GRIA4; PRKACG
    Cocaine addiction PRKACB; GRM3; PRKACG; GPSM1; DRD1; DRD1A; CREB3L2; CREB3L4; CREB3; GNAI2
    Dopaminergic synapse GNB1; GSK3B; DRD5; CAMK2G; PLCB2; DRD1; MAPK13; TH; GNGT2; SLC6A3
    Estrogen signaling pathway GABBR1; FOS; MAP2K2; ESR1; PIK3CA; CREB5; GNAQ; PLCB3; MMP2; HSPA2
    G1 to S cell cycle control TFDP1B; E2F6; MYT1; ATF6B; CDKN1C

    atf6b has several biochemical functions, for example, cAMP response element binding, protein binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by atf6b itself. We selected most functions atf6b had, and list some proteins which have the same functions with atf6b. You can find most of the proteins on our site.

    Function Related Protein
    cAMP response element binding CREB3L3; CREB3L1; JUN; CREB3L2; CREB3L3A; ATF6; CREB3; CREB1; CREB3L3L; HMGA2
    protein binding SKIV2L2; VIPR1; GTSE1; GRIK3; FHL3; C16orf48; HILPDA; RAP2B; IL28RA; SLC26A6
    sequence-specific DNA binding CTCFL; NKX6-1; FOXA3; ZNF396; HIC1; GATA5; NR5A1A; TBX3; HOXB4; RAX2
    transcription factor activity, sequence-specific DNA binding BCL6; ESRRGA; TFE3; CREB3L3L; HOXD3A; ZNF182; TCF4; NME2; EGR2A; MTF1
    transcription regulatory region DNA binding LEF1; SOX17; TCF7; CBX4; RFX6; TNF; GRHL1; SOX5; CCNT1; IKZF1

    atf6b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with atf6b here. Most of them are supplied by our site. Hope this information will be useful for your research of atf6b.

    p27958-pro_0000037575; CDK6; ysuB; proP16; proP17

    Osborne, B; Yao, TW; et al. A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1844:1248-1259(2014).
    Maganti, A; Evans-Molina, C; et al. From immunobiology to beta-cell biology The changing perspective on type 1 diabetes. ISLETS 6:-(2014).

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