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ATF6B

Official Full Name

activating transcription factor 6 beta
Overview

The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms

ATF6B; activating transcription factor 6 beta; cAMP responsive element binding protein like 1 , CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta; G13; G13 protein; ATF 6 beta; ATF6-beta; ATF6B_HUMAN; ATF6beta; cAMP response element binding protein related protein; cAMP response element-binding protein-related protein; cAMP responsive element binding protein like 1; cAMP-dependent transcription factor ATF-6 beta; cAMP-responsive element-binding protein-like 1; CREB L1; Creb related protein; CREB RP; Creb-rp; CREBL 1; CREBL1; Crebrp; Cyclic AMP dependent transcription factor ATF 6 beta; Cyclic AMP dependent transcription factor ATF6 beta; FLJ10066; OTTHUMP00000029432; OTTHUMP00000029433; Processed cyclic AMP-dependent transcription factor ATF-6 beta; Protein G13; Creb-related protein; cAMP responsive element binding protein-like 1;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Mus musculus (Mouse)
Zebrafish

Source

E.coli
E.coli expression system
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ATF6B-26189TH	Recombinant Human ATF6B	Wheat Germ	N/A	87 amino acids	Inquiry
Human	ATF6B-26100TH	Recombinant Human ATF6B Protein, GST-tagged	Wheat Germ	GST	1 a.a. - 318 a.a.	Inquiry
Human	ATF6B-9965H	Recombinant Human ATF6B, GST-tagged	E.coli	GST	1-318a.a.	$319 / 25ug
Human	ATF6B-1520HF	Recombinant Full Length Human ATF6B Protein, GST-tagged	In Vitro Cell Free System	GST	318 amino acids	Inquiry
Mouse	ATF6B-2070M	Recombinant Mouse ATF6B Protein	Mammalian Cell	His		Inquiry
Mouse	ATF6B-816M-B	Recombinant Mouse ATF6B Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	ATF6B-816M	Recombinant Mouse ATF6B Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mus musculus (Mouse)	RFL-9388MF	Recombinant Full Length Mouse Cyclic Amp-Dependent Transcription Factor Atf-6 Beta(Atf6B) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (2-699)	Inquiry
Zebrafish	ATF6B-4821Z	Recombinant Zebrafish ATF6B	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
ATF6B Related Articles

ATF6B involved in several pathways and played different roles in them. We selected most pathways ATF6B participated on our site, such as Adrenergic signaling in cardiomyocytes, Alcoholism, Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATF6B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adrenergic signaling in cardiomyocytes	FXYD2;CAMK2D;ATP1A1;PPP1CAA;MAPK1;Adcy4;ADCY2B;ADCY1;PRKACAA
Alcoholism	SHC1;HIST2H2AA2;HIST1H2AA;GNG10;DDC;SHC4;HIST3H2A;HDAC4;GRIN2C
Aldosterone synthesis and secretion	CALM1;CALML3;AGTR1A;SCARB1;ADCY8;HSD3B1;ATF6B;ATF4;CAMK1G
Cocaine addiction	GNAS;DLG4;CREB5;PRKACG;GRM3;GRM2;PDYN;DDC;DRD1A
Dopaminergic synapse	PRKACB;PPP2R5B;GNG12;GNG3;SLC6A3;PPP2R2A;PPP2R2C;SLC18A2;SCN1A
Estrogen signaling pathway	GNAO1;PIK3R2;SRC;HSPA6;PIK3CA;Adcy4;PLCB1;PIK3R3;NOS3
G1 to S cell cycle control	ATF6B;CDKN1C;MYT1;TFDP1B;E2F6

ATF6B has several biochemical functions, for example, cAMP response element binding, protein binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATF6B itself. We selected most functions ATF6B had, and list some proteins which have the same functions with ATF6B. You can find most of the proteins on our site.

Function	Related Protein
cAMP response element binding	CREB3L3L;ATF6;CREB3L3A;JUN;ATF2;CREB3L1;ATF6B;CREB3L2;HMGA2
protein binding	KIAA1143;CCDC135;ATP6V0C;GAD2;CTPS2;NT5C2;MYOZ2;LEMD3;KIAA0408
sequence-specific DNA binding	POU3F2B;FLI1A;MSXB;PAX3;NR6A1B;NKX2-1;FOXN3;FOXI1;ZSCAN10
transcription factor activity, sequence-specific DNA binding	ETS2;FOXO1B;RFX8;STAT4;SOX13;NFIXB;FOXO3A;HMGA1A;TFAM
transcription regulatory region DNA binding	SP1;HHEX;NR5A2;ZNF567;THRA;CALCOCO1;TFAP4;FOXA1;ATF5

ATF6B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATF6B here. Most of them are supplied by our site. Hope this information will be useful for your research of ATF6B.

p27958-pro_0000037575; CDK6; ysuB; proP16; proP17

Osborne, B; Yao, TW; et al. A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1844:1248-1259(2014).

Maganti, A; Evans-Molina, C; et al. From immunobiology to beta-cell biology The changing perspective on type 1 diabetes. ISLETS 6:-(2014).