Recombinant Full Length Human ATF6B Protein, GST-tagged

• Cat.No.: ATF6B-1520HF
• Product Overview: Recombinant full-length Human ATF6B(1 a.a. - 318 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ.

Specification

• Description: The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene.
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 60.61 kDa
• Protein Length: 318 amino acids
• AA Sequence: MAELMLLSEI ADPTRFFTDN LLSPEDWGLQ NSTLYSGLDE VAEEQTQLFR CPEQDVPFDG SSLDVGMDVS PSEPPWELLP IFPDLQVKSE PSSPCSSSSL SSESSRLSTE PSSEALGVGE VLHVKTESLA PPLCLLGDDP TSSFETVQIN VIPTSDDSSD VQTKIEPVSP CSSVNSEASL LSADSSSQAF IGEEVLEVKT ESLSPSGCLL WDVPAPSLGA VQISMGPSLD GSSGKALPTR KPPLQPKPVV LTTVPMPSRA VSPSTTVLLQ SLVQPPPGTE EGEKGRAWWL TPVIPALWEA EAGESPEVRS LRPAWPTW
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ATF6B activating transcription factor 6 beta [ Homo sapiens ]
• Official Symbol: ATF6B
• Synonyms: ATF6B; activating transcription factor 6 beta; cAMP responsive element binding protein like 1 , CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta; G13; ATF6-beta; protein G13; Creb-related protein; cAMP responsive element binding protein-like 1; cAMP-dependent transcription factor ATF-6 beta; cAMP-responsive element-binding protein-like 1; cAMP response element-binding protein-related protein; CREBL1; CREB-RP; FLJ10066
• Gene ID: 1388
• mRNA Refseq: NM_001136153
• Protein Refseq: NP_001129625
• MIM: 600984
• UniProt ID: Q99941