Recombinant Human ATF6B Protein, GST-tagged

• Cat.No.: ATF6B-26100TH
• Product Overview: Recombinant Human ATF6B(1 a.a. - 318 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ.

Specification

• Description: The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene.
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 60.61 kDa
• Protein length: 1 a.a. - 318 a.a.
• AA Sequence: MAELMLLSEIADPTRFFTDNLLSPE DWGLQNSTLYSGLDEVAEEQTQLFR CPEQDVPFDGSSLDVGMDVSPSEPP WELLPIFPDLQVKSEPSSPCSSSSL SSESSRLSTEPSSEALGVGEVLHVK TESLAPPLCLLGDDPTSSFETVQIN VIPTSDDSSDVQTKIEPVSPCSSVN SEASLLSADSSSQAFIGEEVLEVKT ESLSPSGCLLWDVPAPSLGAVQISM GPSLDGSSGKALPTRKPPLQPKPVV LTTVPMPSRAVSPSTTVLLQSLVQP PPGTEEGEKGRAWWLTPVIPALWEA EAGESPEVRSLRPAWPTW
• Applications: Enzyme-linked Immunoabsorbent; Assay Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: ATF6B activating transcription factor 6 beta [ Homo sapiens ]
• Official Symbol: ATF6B
• Synonyms: ATF6B; activating transcription factor 6 beta; cAMP responsive element binding protein like 1 , CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta; G13; ATF6-beta; protein G13; Creb-related protein; cAMP responsive element binding protein-like 1; cAMP-dependent transcription factor ATF-6 beta; cAMP-responsive element-binding protein-like 1; cAMP response element-binding protein-related protein; CREBL1; CREB-RP; FLJ10066
• Gene ID: 1388
• mRNA Refseq: NM_001136153
• Protein Refseq: NP_001129625
• MIM: 600984
• UniProt ID: Q99941