• Official Full Name

    ATPase, Na+/K+ transporting, alpha 3 polypeptide

  • Background

    The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of;Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the;electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for;osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical;excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a;smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene;encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for;this gene.
  • Synonyms

    ATP1A3; ATPase, Na+/K+ transporting, alpha 3 polypeptide; dystonia 12 , DYT12; sodium/potassium-transporting ATPase subunit alpha-3; Alpha(III); AT1A3_HUMAN; ATPase Na+/K+ transporting alpha 3 polypeptide; DYT 12; DYT12; MGC13276; Na(+)/K(+) ATPase alpha(III) subunit; Na(+)/K(+) ATPase alpha-3 subunit; Na+/K+ ATPase 3; Na+/K+ ATPase alpha 3 subunit; RDP; Sodium potassium ATPase alpha 3 polypeptide; Sodium pump 3; Sodium pump subunit alpha-3; Sodium/potassium transporting ATPase alpha 3 chain; sodium-potassium-ATPase, alpha 3 polypeptide; sodium/potassium-transporting ATPase alpha-3 chain;
    • Type:
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Cell & Tissue Lysates
    • Species :
    • Chicken
    • Human
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Chicken ATP1A3-7024C Recombinant Chicken ATP1A3 Mammalian Cell His
    Human ATP1A3-2517H-B Recombinant Human ATP1A3 Protein Pre-coupled Magnetic Beads HEK293
    Human ATP1A3-963H Recombinant Human ATP1A3 protein, GST-tagged Wheat Germ GST
    Human ATP1A3-366H Recombinant Human ATP1A3 Mammalian Cell His
    Human ATP1A3-3253H Recombinant Human ATP1A3 protein, His-tagged E.coli His
    Human ATP1A3-8611HCL Recombinant Human ATP1A3 293 Cell Lysate HEK293 N/A
    Human ATP1A3-2517H Recombinant Human ATP1A3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human ATP1A3-3254H Recombinant Human ATP1A3 protein, GST-tagged E.coli GST
    Human ATP1A3-3255H Recombinant Human ATP1A3 protein, His-tagged E.coli His
    Human ATP1A3-3256H Recombinant Human ATP1A3 protein, GST-tagged E.coli GST
    Rat ATP1A3-510R-B Recombinant Rat ATP1A3 Protein Pre-coupled Magnetic Beads HEK293
    Rat ATP1A3-510R Recombinant Rat ATP1A3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat ATP1A3-854R Recombinant Rat ATP1A3 Protein Mammalian Cell His
    Rhesus Macaque ATP1A3-448R Recombinant Rhesus monkey ATP1A3 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque ATP1A3-277R Recombinant Rhesus Macaque ATP1A3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque ATP1A3-277R-B Recombinant Rhesus Macaque ATP1A3 Protein Pre-coupled Magnetic Beads HEK293
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • ATP1A3 Related Articles

    ATP1A3 involved in several pathways and played different roles in them. We selected most pathways ATP1A3 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cGMP-PKG signaling pathwayPLCB4;BAD;ATP2B4;PIK3CB;IRS1;GNAI3;ATP2A3;CALM2;BNP
    Cardiac muscle contractionUQCRC2A;TNNT2A;MYL2B;ATP1A1B;CACNG8;CACNB4;CACNB2;CACNA2D4;COX6A1
    Adrenergic signaling in cardiomyocytesPPP2R5CB;PIK3R5;PIK3CG;PPP2R5E;CACNG3;PRKACAA;CACNG7;SCN1BB;TPM4A
    Insulin secretionATP1B3;GPR119;KCNJ11;KCNN1;KCNMB3;CAMK2G;ATP1A4;ATP1A2;PRKACA
    Thyroid hormone synthesisGNAS;TPO;ATP1A1;HSPA5;GPX8;ATP1A4;TSHR;GPX7;PLCB3
    Thyroid hormone signaling pathwayMED17;MTOR;PRKCG;MAP2K1;STAT1;PLCB1;CASP9;MED14;TBC1D4
    Aldosterone-regulated sodium reabsorptionPIK3CD;IGF1;ATP1A2;INS2;ATP1A3;ATP1A1;SCNN1B;PRKCG;MAPK3
    Endocrine and other factor-regulated calcium reabsorptionKLK1B1;PLCB3;KLK1B9;KLK1B26;PRKCA;KL;ATP1B3;KLK2;PRKCB
    Proximal tubule bicarbonate reclamationATP1B4;ATP1A2;GLS2;ATP1B1;Car2;ATP1A1;GLUD2;ATP1B2;ATP1A4
    Salivary secretionTRPV6;PRKACG;CAP18;CST4;ATP2B4;HTN1;ATP1B3;PRH2;LYZ1
    Pancreatic secretionCELA2B;CCKAR;PNLIPRP1;ATP1A3;ATP1B2;CD38;ATP2A2;ATP1A2;PLCB1
    Carbohydrate digestion and absorptionG6PC;AKT1;G6PC2;HK1;HK2;FXYD2;AMY2A;PIK3R3;HKDC1
    Protein digestion and absorptionATP1A3;CPB1;ATP1A1;ATP1A2;COL6A4;CPA2;SLC1A1;COL7A1;COL6A6
    Bile secretionHMGCR;SLC2A1;SLC22A1;LDLR;Car2;ATP1B2;FXYD2;Slc4a2;ATP1A4
    Mineral absorptionATP1A1;TF;SLC8A1;STEAP2;MT1H;SLC30A1;SLC34A2;ATP1B4;MT2A

    ATP1A3 has several biochemical functions, for example, ATP binding, D1 dopamine receptor binding, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1A3 itself. We selected most functions ATP1A3 had, and list some proteins which have the same functions with ATP1A3. You can find most of the proteins on our site.

    Function Related Protein
    D1 dopamine receptor bindingATP1A3;DLG4;ARRB2;PTPN11;DRD3;GNAS;AGTR1A;CAV2
    chaperone bindingVWF;DNAJA2L;GRPEL1;TFRC;CXorf41;DNAJB7;STIP1;UBL4A;DNAJA2
    metal ion bindingRNF150A;CSK;TRIM35-29;ZFP637;COL2A1;ENOPH1;IHHB;SP4;NGLY1
    sodium:potassium-exchanging ATPase activityATP1A1A.3;ATP1A2;ATP1A4;ATP1B3;FXYD2;ATP1A2A;ATP4A;ATP1A1B;ATP1A3A
    steroid hormone bindingATP1A1;ESR2B;ESR2A;GPR30;ATP1A3;NR3C1;ATP1A2

    ATP1A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1A3.

    PCBD1; ATXN1; CASP8; 15-deoxy-delta(12,14; a52_vaccw; AGO2

    Murakami, Y; Ikeda, U; et al. Promoter of the Na,K-ATPase alpha 3 subunit gene is composed of cis elements to which NF-Y and Sp1/Sp3 bind in rat cardiocytes. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1352:311-324(1997).
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