ATP1A3

  • Official Full Name

    ATPase, Na+/K+ transporting, alpha 3 polypeptide

  • Overview

    The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of;Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the;electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for;osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical;excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a;smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene;encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for;this gene.
  • Synonyms

    ATP1A3; ATPase, Na+/K+ transporting, alpha 3 polypeptide; dystonia 12 , DYT12; sodium/potassium-transporting ATPase subunit alpha-3; Alpha(III); AT1A3_HUMAN; ATPase Na+/K+ transporting alpha 3 polypeptide; DYT 12; DYT12; MGC13276; Na(+)/K(+) ATPase alpha(III) subunit; Na(+)/K(+) ATPase alpha-3 subunit; Na+/K+ ATPase 3; Na+/K+ ATPase alpha 3 subunit; RDP; Sodium potassium ATPase alpha 3 polypeptide; Sodium pump 3; Sodium pump subunit alpha-3; Sodium/potassium transporting ATPase alpha 3 chain; sodium-potassium-ATPase, alpha 3 polypeptide; sodium/potassium-transporting ATPase alpha-3 chain;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP1A3-366H Recombinant Human ATP1A3 Mammalian Cell His
Human ATP1A3-963H Recombinant Human ATP1A3 protein, GST-tagged Wheat Germ GST
Human ATP1A3-8611HCL Recombinant Human ATP1A3 293 Cell Lysate HEK293 N/A
Human ATP1A3-2517H-B Recombinant Human ATP1A3 Protein Pre-coupled Magnetic Beads HEK293
Human ATP1A3-3253H Recombinant Human ATP1A3 protein, His-tagged E.coli His
Human ATP1A3-3254H Recombinant Human ATP1A3 protein, GST-tagged E.coli GST
Human ATP1A3-1088HF Recombinant Full Length Human ATP1A3 Protein, GST-tagged In Vitro Cell Free System GST
Human ATP1A3-3255H Recombinant Human ATP1A3 protein, His-tagged E.coli His
Human ATP1A3-2517H Recombinant Human ATP1A3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ATP1A3-3256H Recombinant Human ATP1A3 protein, GST-tagged E.coli GST
Rat ATP1A3-854R Recombinant Rat ATP1A3 Protein Mammalian Cell His
Rat ATP1A3-510R Recombinant Rat ATP1A3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ATP1A3-510R-B Recombinant Rat ATP1A3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ATP1A3-448R Recombinant Rhesus monkey ATP1A3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ATP1A3-277R Recombinant Rhesus Macaque ATP1A3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ATP1A3-277R-B Recombinant Rhesus Macaque ATP1A3 Protein Pre-coupled Magnetic Beads HEK293
Chicken ATP1A3-7024C Recombinant Chicken ATP1A3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ATP1A3 Related Articles

ATP1A3 involved in several pathways and played different roles in them. We selected most pathways ATP1A3 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cGMP-PKG signaling pathwayNFATC1;GNAI3;ITPR1;ATP1B4;ATP1A4;PIK3R3;PDE3A;PIK3CD;GNA12
cAMP signaling pathwayGPR119;DRD1A;GNAI3;CNGA1;OXTR;NPY;PTGER2;PPARA;PIK3R1
Cardiac muscle contractionSLC8A1;ATP1B1;CACNB1;CACNB3;COX7A1;COX6A2;CACNA1DA;UQCRC1;COX6B1
Adrenergic signaling in cardiomyocytesCAMK2B1;ATP1B1;KCNQ1;ATP2B3B;ATP2B2;CREB3L2;CAMK2G1;MAPK14;CACNB1
Insulin secretionGNA11;RAPGEF4;CREB3L1;SLC2A1;ATP1B2;CREB5;RYR2;PLCB4;GIP
Thyroid hormone synthesisATP1B3;PRKCA;ASGR1;ATP1A4;PRKACG;TSHB;CREB5;PDIA4;PLCB4
Thyroid hormone signaling pathwayPIK3CD;PIK3CA;HDAC2;AKT1;MAP2K2;NOTCH3;PLCB4;PLN;PLCG1
Aldosterone-regulated sodium reabsorptionALPHA-ENAC;PIK3R3;INS1;KRAS;SGK1;SCNN1B;PIK3CG;ATP1A3;PIK3CB
Endocrine and other factor-regulated calcium reabsorptionPLCB1;ESR1;PRKCB;VDR;PRKACA;ATP2B1;PRKACB;KLK1B8;ATP1A3
Proximal tubule bicarbonate reclamationATP1A1;ATP1A3;CA4;GLS;ATP1B4;ATP1A4;GLS2;GLUD1;FXYD2
Salivary secretionITPR1;PRKG1;KCNN4;PRKCG;FXYD2;ATP1B4;BST1;MUC5B;MUC7
Gastric acid secretionPLCB1;KCNQ1;MYLK3;SST;CALM4;SLC26A7;PLCB4;KCNE2;KCNJ1
Pancreatic secretionLOC780933;SLC4A4;PLCB4;PLA2G5;SLC9A1;ATP1A3;SLC26A3;KCNQ1;RAB11A
Carbohydrate digestion and absorptionAMY2A4;ATP1A1;AMY1B;GNAT3;PIK3R1;G6PC;AKT1;PRKCB;ATP1B3
Protein digestion and absorptionATP1B4;COL13A1;PRSS3;ATP1B2;COL27A1;ATP1A3;CPA2;KCNK5;COL6A6
Bile secretionNR1H4;ADCY6;BAAT;OSTA;SLCO1A6;AQP9;CA2;SLC22A8;ATP1B4
Mineral absorptionATOX1;MT1X;SLC11A1;CYBRD1;MT1E;ATP1B3;SLC34A2;SLC46A1;FTL

ATP1A3 has several biochemical functions, for example, ATP binding, D1 dopamine receptor binding, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1A3 itself. We selected most functions ATP1A3 had, and list some proteins which have the same functions with ATP1A3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingABCF2;CAMKK2;SMYHC2;SMARCAD1;LRRK2;FBXO18;NAIP1;GLULB;TYRO3
D1 dopamine receptor bindingCAV2;ATP1A3;AGTR1A;DLG4;PTPN11;GNAS;ARRB2;DRD3
chaperone bindingPRNP;HLA-B;HYOU1;C1orf182;GET4;HSPA5;SYVN1;TIMM44;BAG3
metal ion bindingTPH1B;CYP27C1;KAT6A;AARS;COL27A1A;NRXN2A;DZIP1L;ANGPT2;NRXN3
sodium:potassium-exchanging ATPase activityATP1A1A.3;ATP1B3;ATP1A1A.5;ATP4A;ATP1A1A.4;ATP1A2;ATP1B2;FXYD2;ATP1A4
steroid hormone bindingESR2A;NR3C1;GPR30;ATP1A1;ATP1A3;ESR2B;ATP1A2

ATP1A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1A3.

PCBD1; ATXN1; CASP8; 15-deoxy-delta(12,14; a52_vaccw; AGO2

Murakami, Y; Ikeda, U; et al. Promoter of the Na,K-ATPase alpha 3 subunit gene is composed of cis elements to which NF-Y and Sp1/Sp3 bind in rat cardiocytes. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1352:311-324(1997).
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