• Official Full Name

    ATPase, Ca++ transporting, plasma membrane 3

  • Overview

    The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms

    ATP2B3; ATPase, Ca++ transporting, plasma membrane 3; plasma membrane calcium-transporting ATPase 3; plasma membrane calcium transporting ATPase 3; PMCA3; plasma membrane calcium pump; plasma membrane calcium ATPase; PMCA3a;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP2B3-267H Recombinant Human ATP2B3 Protein, His-tagged E.coli N-His Thr1057-Leu1220
Mouse ATP2B3-12M Recombinant Mouse ATP2B3 Protein, His-tagged E.coli His
Rat ATP2B3-863R Recombinant Rat ATP2B3 Protein Mammalian Cell His
Rat ATP2B3-519R Recombinant Rat ATP2B3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ATP2B3-519R-B Recombinant Rat ATP2B3 Protein Pre-coupled Magnetic Beads HEK293
  • Other Resource

ATP2B3 involved in several pathways and played different roles in them. We selected most pathways ATP2B3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP2B3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ATP2B3 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ATP2B3 itself. We selected most functions ATP2B3 had, and list some proteins which have the same functions with ATP2B3. You can find most of the proteins on our site.

Function Related Protein

ATP2B3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP2B3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP2B3.

Research Area

Related articles

Talarico, EF; et al. Plasma membrane calcium-ATPase isoform four distribution changes during corneal epithelial wound healing. MOLECULAR VISION 16:2259-2272(2010).
Ramoino, P; Milanese, M; et al. gamma-Amino butyric acid (GABA) release in the ciliated protozoon Paramecium occurs by neuronal-like exocytosis. JOURNAL OF EXPERIMENTAL BIOLOGY 213:1251-1258(2010).
  • Q&As
  • Reviews

Q&As (6)

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How is the protein structure and function of ATP2B3 different from other atpase B family members? 11/10/2022

There are several differences in protein structure and function between ATP2B3 and other atpase B family members, mainly depending on how they are expressed and regulated in different tissues and cells.

Are mutations in ATP2B3 associated with rare genetic diseases? 09/07/2021

ATP2B3 gene mutation may be associated with some hereditary diseases such as pigmentary papillomatosis and atrial fibrillation/flutte

Is ATP2B3 associated with neurological diseases? 02/21/2021

At present, studies have shown that ATP2B3 is associated with nervous system diseases such as Parkinson's disease and Alzheimer's disease.

What are the pathways of ATP2B3 protein production? 01/08/2021

The production pathway of ATP2B3 protein mainly includes multiple biological processes such as gene transcription, RNA splicing, protein translation and subsequent modification.

What is the regulatory mechanism of ATP2B3? 10/04/2020

The regulatory mechanism of ATP2B3 may involve multiple signaling pathways and factors, such as calcium ions, ATP, membrane receptors, etc.

What is the relationship between ATP2B3 and cardiovascular disease? 08/03/2020

The relationship between ATP2B3 and cardiovascular disease may be achieved through several mechanisms such as regulating cardiomyocyte contraction and vascular smooth muscle cell contraction.

Customer Reviews (3)

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    ATP2B3 were of very high quality and reliable, which is very helpful to our results.


      Due to the high purity of ATP2B3, its production process is very quality-oriented.


        The reproducibility of ATP2B3 is very good, and the results of each experiment are very consistent, indicating that its production process is very careful.

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