ATP5F1
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Official Full Name
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
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Background
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the b subunit of the proton channel. -
Synonyms
ATP5F1; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 1 , ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1; ATP synthase subunit b, mitochondrial; mitochondrial; AT5F1_HUMAN; ATP synthase B chain mitochondrial; ATP synthase subunit b; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b,; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1; ATPase subunit b; Cell proliferation inducing protein 47; H+ ATP synthase subunit b; MGC24431; PIG47; H+-ATP synthase subunit b; ATP synthase B chain, mitochondrial; cell proliferation-inducing protein 47; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 1;
- Involved Pathway
- Protein Function
- Interacting Protein
ATP5F1 involved in several pathways and played different roles in them. We selected most pathways ATP5F1 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP5F1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oxidative phosphorylation | ATP6V1C1;ATP6V1H;MT-ND1;UQCRC2B;UQCRB;NDUFA9;PPA2;mt-Atp8;NDUFS8 |
| Metabolic pathways | HPRT1;XDH;ACOT1;LPIN2;PLA2G5;B3GNT5B;LASS4;MAN1A2;PISD |
| Alzheimers disease | NCSTN;COX7B;APOE;ITPR1;PLCB1;NDUFS4;CALML3;LPL;NDUFS6 |
| Parkinsons disease | UQCRC2;NDUFC2-KCTD14;SEPT5;DRD1A;TH;ATP5B;NDUFA4L2;SLC18A1;UBE2L3 |
| Huntingtons disease | NDUFS6;UQCRC2;NDUFS2;HDAC1;DNAH11;NDUFA11;DNALI1;NDUFB1;COX6C |
ATP5F1 has several biochemical functions, for example, contributes_to ATPase activity, protein binding, contributes_to proton-transporting ATP synthase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP5F1 itself. We selected most functions ATP5F1 had, and list some proteins which have the same functions with ATP5F1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ATPase activity | ATP5D;RFC3;ATP5F1;ATP5B;ABCA7;ATP5H;MSH6;ATP5J;MSH2 |
| protein binding | AP5Z1;SSX1;IFT172;IREB2;EDF1;PAN3;UBE3C;CLOCKA;OSBPL1A |
| contributes_to proton-transporting ATP synthase activity, rotational mechanism | ATP5F1;ATP5D |
| transmembrane transporter activity | SLC22A23;SLC2A13B;ATP5D;SV2C;SLCO1D1;SLC17A9B;SV2A;ATP5H;SLC22A7B.1 |
ATP5F1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP5F1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP5F1.
vpu; ATP5H; ATP5L; ATP5B; ATP5J; ATP5A1; ATP5D; ATP5C1; VHL; ATP5J2; ATP5I
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