• Official Full Name

    ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 [ Homo sapiens ]

  • Overview

    This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D.
  • Synonyms

    ATP6C; ATP6D; ATP6V1C1; ATPase H+ transporting lysosomal (vacuolar proton pump) 42kD; ATPase H+ transporting lysosomal 42kD V1 subunit C isoform 1; ATPase H+ transporting lysosomal 42kDa V1 subunit C isoform 1; ATPase H+ transporting lysosomal 42kDa V1 subunit C1; ATPase H+ transporting lysosomal V1 subunit C1; FLJ20057; H(+) transporting two sector ATPase subunit C; H+ ATPase C subunit; H+ transporting ATPase chain C vacuolar; Subunit C of vacuolar proton ATPase V1 domain; V ATPase C subunit; V ATPase subunit C 1; V-ATPase subunit C 1; V-type proton ATPase subunit C 1; Vacuolar ATP synthase subunit C; Vacuolar proton pump 42 kD subunit; Vacuolar proton pump C subunit; Vacuolar proton pump subunit C 1; Vacuolar protonATPase subunit C VI domain; VATC; VATC1_HUMAN; VATPase C subunit; VATPase subunit C 1; VMA5;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP6V1C1-10043H Recombinant Human ATP6V1C1, GST-tagged E.coli GST 1-381a.a.
Human ATP6V1C1-1003H Recombinant Human ATP6V1C1 protein, GST-tagged Wheat Germ GST
Human ATP6V1C1-8582HCL Recombinant Human ATP6V1C1 293 Cell Lysate HEK293 N/A
Human ATP6V1C1-1161H Recombinant Human ATP6V1C1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ATP6V1C1-1527HF Recombinant Full Length Human ATP6V1C1 Protein, GST-tagged In Vitro Cell Free System GST 382 amino acids
Mouse ATP6V1C1-2161M Recombinant Mouse ATP6V1C1 Protein Mammalian Cell His
Mouse Atp6v1c1-1773M Recombinant Mouse Atp6v1c1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ATP6V1C1-877M-B Recombinant Mouse ATP6V1C1 Protein Pre-coupled Magnetic Beads HEK293
Mouse ATP6V1C1-877M Recombinant Mouse ATP6V1C1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ATP6V1C1-891R Recombinant Rat ATP6V1C1 Protein Mammalian Cell His
Rat ATP6V1C1-547R-B Recombinant Rat ATP6V1C1 Protein Pre-coupled Magnetic Beads HEK293
Rat ATP6V1C1-547R Recombinant Rat ATP6V1C1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey ATP6V1C1-327C Recombinant Cynomolgus ATP6V1C1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey ATP6V1C1-77C Recombinant Cynomolgus Monkey ATP6V1C1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey ATP6V1C1-77C-B Recombinant Cynomolgus Monkey ATP6V1C1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ATP6V1C1-467R Recombinant Rhesus monkey ATP6V1C1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ATP6V1C1-296R-B Recombinant Rhesus Macaque ATP6V1C1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ATP6V1C1-296R Recombinant Rhesus Macaque ATP6V1C1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

Atp6v1c1 involved in several pathways and played different roles in them. We selected most pathways Atp6v1c1 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with Atp6v1c1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Oxidative phosphorylationATP5G3;NDUFA3;NDUFA11;LHPP;SDHD;NDUFA4L2;SDHDB;ATP6V0A1A;COX7A1
Metabolic pathwaysB3GALNT1;FUT5;CYP51A1;SAT1;CDS2;CYP2S1;NDUFB4;GGT5A;NDUFB5
Synaptic vesicle cycleATP6V0C;ATP6V1G2;SNAP25;STX1A;ATP6V1C1;ATP6V1F;ATP6V1E1;ATP6V1E2;ATP6V1C2
Collecting duct acid secretionSLC12A7;ATP6V1E1;CA2;ATP6V0A1;ATP6V1B1;ATP6V1G3;ATP6V1G1;ATP4B;ATP6V0E1
Vibrio cholerae infectionATP6V1D;KDELR1;ATP6V1A;ATP6V1B2;MUC2;ATP6V1E1;KDELR2;ATP6V1F;ATP6V0C
Epithelial cell signaling in Helicobacter pylori infectionMAPK12;NFKB1;ATP6V1H;LYN;ATP6V1B2;CCL5;TJP1;ADAM17;CDC42

Atp6v1c1 has several biochemical functions, for example, hydrogen-exporting ATPase activity, phosphorylative mechanism, protein binding, proton-transporting ATPase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by Atp6v1c1 itself. We selected most functions Atp6v1c1 had, and list some proteins which have the same functions with Atp6v1c1. You can find most of the proteins on our site.

Function Related Protein
hydrogen-exporting ATPase activity, phosphorylative mechanismATP6V1E1;ATP6V1C1;ATP6V1E2;ATP6V1G3;ATP6V0D1;ATP6V1G1;ATP6V1C2
protein bindingCDC23;DACT2;MCM10;C2orf65;RNF182;INMT;POLR1A;MANBAL;ZNF624
proton-transporting ATPase activity, rotational mechanismATP6V0CB;ATP6V1E2;ATP6V0C;ATP5C1;ATP6AP1;ATP5D;ATP6V1B2;ATP6V0CA;ATP6V0E
transporter activityAQP1A.2;AQP10B;APODA.1;CRABP2B;ABCA9;SLCO4C1;SLC15A1B;OSTB;LCN12

Atp6v1c1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Atp6v1c1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Atp6v1c1.

ARF6; PPARG; Arf6; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; pi3p; PPP2R1A; ATP6V1A; SMS

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