• Official Full Name

    ATPase, Cu++ transporting, alpha polypeptide

  • Overview

    This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans-Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked cutis laxa, and occipital horn syndrome.
  • Synonyms

    ATP7A; ATPase, Cu++ transporting, alpha polypeptide; Menkes syndrome , MNK; copper-transporting ATPase 1; copper pump 1; Cu++-transporting P-type ATPase; Menkes disease-associated protein; MK; MNK; DSMAX; SMAX3; FLJ17790;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP7A-27417TH Recombinant Human ATP7A Wheat Germ N/A 95 amino acids
Human ATP7A-459H Recombinant Human ATPase, Cu++ Transporting, Alpha Polypeptide E.coli N/A
Human ATP7A-455H Recombinant Human ATP7A, Domain 2 E.coli N/A
Human ATP7A-458H Recombinant Human ATP7A, Domain 5 E.coli N/A
Human ATP7A-460H Recombinant Human ATPase, Cu++ Transporting, Alpha Polypeptide, His-tagged E.coli His
Human ATP7A-454H Recombinant Human Menkes Protein, Domain 1 E.coli N/A
Human ATP7A-456H Recombinant Human Menkes Protein, Domain 3 E.coli N/A
Human ATP7A-1013H Recombinant Human ATP7A protein, GST-tagged Wheat Germ GST
Human ATP7A-273H Recombinant Human ATP7A Protein, His-tagged E.coli N-His Ser9-Leu444
Mouse Atp7a-274M Recombinant Mouse Atp7a Protein, His-tagged E.coli N-His Ser9-Leu444
Rat ATP7A-895R Recombinant Rat ATP7A Protein Mammalian Cell His
Rat ATP7A-551R Recombinant Rat ATP7A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ATP7A-551R-B Recombinant Rat ATP7A Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ATP7A-3828Z Recombinant Zebrafish ATP7A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ATP7A involved in several pathways and played different roles in them. We selected most pathways ATP7A participated on our site, such as Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP7A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Mineral absorptionSTEAP1;ATP1A2;ATP1A4;SLC5A1;SLC8A1;CLCN2;ATP1A1;SLC34A2;ATP1B4

ATP7A has several biochemical functions, for example, ATP binding, copper ion binding, copper ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP7A itself. We selected most functions ATP7A had, and list some proteins which have the same functions with ATP7A. You can find most of the proteins on our site.

Function Related Protein
copper ion bindingPAM;ABP1;SNAI3;AOC3;IL1A;TYRP1;CCS;HEPHL1;MT3
copper ion transmembrane transporter activityMMGT2;SLC11A2;ATOX1;SLC31A2;SLC31A1;ATP7A
copper-dependent protein bindingATOX1;ATP7A;FKBP4
copper-exporting ATPase activityATP7A;ATP7B
protein bindingMUTED;KIAA1191;GFOD1;LZTS2;PABPC1;TP53;CORO1B;CDK15;SLC6A4
superoxide dismutase copper chaperone activityCCS;PARK7;ATP7A

ATP7A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP7A here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP7A.


Research Area

Related articles

Yi, L; Kaler, S; et al. ATP7A trafficking and mechanisms underlying the distal motor neuropathy induced by mutations in ATP7A. HUMAN DISORDERS OF COPPER METABOLISM I 1314:49-54(2014).
Palm-Espling, ME; Lundin, C; et al. Interaction between the Anticancer Drug Cisplatin and the Copper Chaperone Atox1 in Human Melanoma Cells. PROTEIN AND PEPTIDE LETTERS 21:63-68(2014).
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