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ATP7A

Official Full Name

ATPase, Cu++ transporting, alpha polypeptide
Overview

This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans-Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked cutis laxa, and occipital horn syndrome.
Synonyms

ATP7A; ATPase, Cu++ transporting, alpha polypeptide; Menkes syndrome , MNK; copper-transporting ATPase 1; copper pump 1; Cu++-transporting P-type ATPase; Menkes disease-associated protein; MK; MNK; DSMAX; SMAX3; FLJ17790;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ATP7A-27417TH	Recombinant Human ATP7A	Wheat Germ	Non	95 amino acids	Inquiry
Human	ATP7A-459H	Recombinant Human ATPase, Cu++ Transporting, Alpha Polypeptide	E.coli	Non		Inquiry
Human	ATP7A-455H	Recombinant Human ATP7A, Domain 2	E.coli	Non		Inquiry
Human	ATP7A-458H	Recombinant Human ATP7A, Domain 5	E.coli	Non		Inquiry
Human	ATP7A-460H	Recombinant Human ATPase, Cu++ Transporting, Alpha Polypeptide, His-tagged	E.coli	His		Inquiry
Human	ATP7A-454H	Recombinant Human Menkes Protein, Domain 1	E.coli	Non		Inquiry
Human	ATP7A-456H	Recombinant Human Menkes Protein, Domain 3	E.coli	Non		Inquiry
Human	ATP7A-1013H	Recombinant Human ATP7A protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	ATP7A-273H	Recombinant Human ATP7A Protein, His-tagged	E.coli	His	Ser9-Leu444	Inquiry
Mouse	Atp7a-274M	Recombinant Mouse Atp7a Protein, His-tagged	E.coli	His	Ser9-Leu444	Inquiry
Rat	ATP7A-895R	Recombinant Rat ATP7A Protein	Mammalian Cell	His		Inquiry
Rat	ATP7A-551R	Recombinant Rat ATP7A Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rat	ATP7A-551R-B	Recombinant Rat ATP7A Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	ATP7A-3828Z	Recombinant Zebrafish ATP7A	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

ATP7A involved in several pathways and played different roles in them. We selected most pathways ATP7A participated on our site, such as Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP7A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Mineral absorption	CYBRD1;TRPM6;SLC5A1;SLC40A1;Trf;MT2;MT1B;ATP2B1;SLC31A1

ATP7A has several biochemical functions, for example, ATP binding, copper ion binding, copper ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP7A itself. We selected most functions ATP7A had, and list some proteins which have the same functions with ATP7A. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	CSNK1G2A;AXL;LANCL2;AK7;PARS2;ATP2B4;KIF9;NLRP9C;ETNK1
copper ion binding	TRP53;LOXL2;LOX;LOXL4;PRNP;LOXL3B;TYRP1B;S100V2;ABHD1
copper ion transmembrane transporter activity	ATOX1;ATP7A;MMGT2;SLC31A2;SLC31A1;SLC11A2
copper-dependent protein binding	ATOX1;FKBP4;ATP7A
copper-exporting ATPase activity	ATP7A;ATP7B
protein binding	SMAD5;FBXW7;C21orf56;TAS2R16;PSRC1;CASP2;DROSHA;UBE2L6;TNNI2
superoxide dismutase copper chaperone activity	CCS;PARK7;ATP7A

ATP7A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP7A here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP7A.

PDZD11

Research Area

Yi, L; Kaler, S; et al. ATP7A trafficking and mechanisms underlying the distal motor neuropathy induced by mutations in ATP7A. HUMAN DISORDERS OF COPPER METABOLISM I 1314:49-54(2014).

Palm-Espling, ME; Lundin, C; et al. Interaction between the Anticancer Drug Cisplatin and the Copper Chaperone Atox1 in Human Melanoma Cells. PROTEIN AND PEPTIDE LETTERS 21:63-68(2014).