ATP7A

  • Official Full Name

    ATPase, Cu++ transporting, alpha polypeptide

  • Background

    This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans-Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked cutis laxa, and occipital horn syndrome.
  • Synonyms

    ATP7A; ATPase, Cu++ transporting, alpha polypeptide; Menkes syndrome , MNK; copper-transporting ATPase 1; copper pump 1; Cu++-transporting P-type ATPase; Menkes disease-associated protein; MK; MNK; DSMAX; SMAX3; FLJ17790;
    • Type:
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ATP7A-27417TH Recombinant Human ATP7A Wheat Germ N/A
    Human ATP7A-459H Recombinant Human ATPase, Cu++ Transporting, Alpha Polypeptide E.coli N/A
    Human ATP7A-455H Recombinant Human ATP7A, Domain 2 E.coli N/A
    Human ATP7A-458H Recombinant Human ATP7A, Domain 5 E.coli N/A
    Human ATP7A-273H Recombinant Human ATP7A Protein, His-tagged E.coli N-His
    Human ATP7A-460H Recombinant Human ATPase, Cu++ Transporting, Alpha Polypeptide, His-tagged E.coli His
    Human ATP7A-454H Recombinant Human Menkes Protein, Domain 1 E.coli N/A
    Human ATP7A-456H Recombinant Human Menkes Protein, Domain 3 E.coli N/A
    Human ATP7A-1013H Recombinant Human ATP7A protein, GST-tagged Wheat Germ GST
    Mouse Atp7a-274M Recombinant Mouse Atp7a Protein, His-tagged E.coli N-His
    Rat ATP7A-551R Recombinant Rat ATP7A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat ATP7A-551R-B Recombinant Rat ATP7A Protein Pre-coupled Magnetic Beads HEK293
    Rat ATP7A-895R Recombinant Rat ATP7A Protein Mammalian Cell His
    Zebrafish ATP7A-3828Z Recombinant Zebrafish ATP7A Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • ATP7A Related Articles

    ATP7A involved in several pathways and played different roles in them. We selected most pathways ATP7A participated on our site, such as Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP7A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Mineral absorptionHMOX1;ATP1B1;SLC26A3;MT1H;SLC9A3;SLC31A1;FTL;TRPM6;SLC11A1

    ATP7A has several biochemical functions, for example, ATP binding, copper ion binding, copper ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP7A itself. We selected most functions ATP7A had, and list some proteins which have the same functions with ATP7A. You can find most of the proteins on our site.

    Function Related Protein
    ATP bindingHSPA1B;PRKAG2;TLK1A;MAP3K15;ATP2C1;CDK6;MCM2;CAMKVB;MAPKAPK2A
    copper ion bindingF5;LOXL3B;APOA4;SCO2;COX11;P2RX2;METTL17;ANG;ATOX1
    copper ion transmembrane transporter activityATOX1;SLC31A2;MMGT2;SLC31A1;SLC11A2;ATP7A
    copper-dependent protein bindingATOX1;FKBP4;ATP7A
    copper-exporting ATPase activityATP7B;ATP7A
    protein bindingASMTL;NCF1;MS4A3;GNAI1;MCM7;CCDC42;HMOX1;WDFY3;SOX13
    superoxide dismutase copper chaperone activityATP7A;PARK7;CCS

    ATP7A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP7A here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP7A.

    PDZD11

    Yi, L; Kaler, S; et al. ATP7A trafficking and mechanisms underlying the distal motor neuropathy induced by mutations in ATP7A. HUMAN DISORDERS OF COPPER METABOLISM I 1314:49-54(2014).
    Palm-Espling, ME; Lundin, C; et al. Interaction between the Anticancer Drug Cisplatin and the Copper Chaperone Atox1 in Human Melanoma Cells. PROTEIN AND PEPTIDE LETTERS 21:63-68(2014).
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