atp7a

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atp7a

Official Full Name ATPase, Cu++ transporting, alpha polypeptide
Background This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans-Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked cutis laxa, and occipital horn syndrome.
Synonyms ATP7A; ATPase, Cu++ transporting, alpha polypeptide; Menkes syndrome , MNK; copper-transporting ATPase 1; copper pump 1; Cu++-transporting P-type ATPase; Menkes disease-associated protein; MK; MNK; DSMAX; SMAX3; FLJ17790
    • Species :
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ATP7A-1013H Recombinant Human ATP7A protein, GST-tagged Wheat Germ GST
    Human ATP7A-27417TH Recombinant Human ATP7A Wheat Germ N/A
    Human ATP7A-454H Recombinant Human Menkes Protein, Domain 1 E.coli N/A
    Human ATP7A-455H Recombinant Human ATP7A, Domain 2 E.coli N/A
    Human ATP7A-456H Recombinant Human Menkes Protein, Domain 3 E.coli N/A
    Human ATP7A-458H Recombinant Human ATP7A, Domain 5 E.coli N/A
    Human ATP7A-459H Recombinant Human ATPase, Cu++ Transporting, Alpha Polypeptide E.coli N/A
    Human ATP7A-460H Recombinant Human ATPase, Cu++ Transporting, Alpha Polypeptide, His-tagged E.coli His
    Rat ATP7A-895R Recombinant Rat ATP7A Protein Mammalian Cell His
    Zebrafish ATP7A-3828Z Recombinant Zebrafish ATP7A Mammalian Cell His

    atp7a involved in several pathways and played different roles in them. We selected most pathways atp7a participated on our site, such as Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with atp7a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Mineral absorption ATP1B4; SLC31A1; ATP1A1; HEPH; ATP7A; SLC26A6; SLC11A1; MT1B; CLCN2; FXYD2

    atp7a has several biochemical functions, for example, ATP binding, copper ion binding, copper ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by atp7a itself. We selected most functions atp7a had, and list some proteins which have the same functions with atp7a. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding EPHB4A; TRPM6; MYLK4; EGFRA; LANCL2; PLK3; MYH9; STRADA; ATAD3A; P2RY1
    copper ion binding TP53; COX17; ANG; CUTC; SCO2; HAMP; S100V2; F8; LOXL2A; SOD3A
    copper ion transmembrane transporter activity MMGT2; SLC31A2; SLC31A1; ATP7A; ATOX1; SLC11A2
    copper-dependent protein binding FKBP4; ATP7A; ATOX1
    copper-exporting ATPase activity ATP7B; ATP7A
    protein binding TGFBR3; SLC7A11; CCND3; BAI3; ELP4; OLFM3; OTUB2; MCC; CCDC170; AHR
    superoxide dismutase copper chaperone activity PARK7; CCS; ATP7A

    atp7a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with atp7a here. Most of them are supplied by our site. Hope this information will be useful for your research of atp7a.

    PDZD11

    Yi, L; Kaler, S; et al. ATP7A trafficking and mechanisms underlying the distal motor neuropathy induced by mutations in ATP7A. HUMAN DISORDERS OF COPPER METABOLISM I 1314:49-54(2014).
    Palm-Espling, ME; Lundin, C; et al. Interaction between the Anticancer Drug Cisplatin and the Copper Chaperone Atox1 in Human Melanoma Cells. PROTEIN AND PEPTIDE LETTERS 21:63-68(2014).

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