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Official Full Name UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
Background This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Three transcript variants encoding two different isoforms have been found for this gene.
Synonyms B4GALT2; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2; beta-1,4-galactosyltransferase 2; beta4Gal T2; Beta 1,4 galactosyltransferase 2; B4Gal T2; Beta 1,4 GalTase 2; Beta 4 GalT2; Beta N acetylglucosaminyl glycolipid beta 1,4 galactosyltransferase 2; UDP Gal:beta GlcNAc beta 1,4 galactosyltransferase 2; UDP Gal:betaGlcNAc beta 1,4 galactosyltransferase polypeptide 2; UDP galactose:beta N acetylglucosamine beta 1,4 galactosyltransferase 2; beta-4-GalT2; beta-1,4-GalTase 2; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 2; UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 2; beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 2; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2; B4Gal-T2; B4Gal-T3; beta4Gal-T2
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human B4GALT2-029H Recombinant Human B4GALT2 protein, GST-tagged Wheat Germ GST
    Human B4GALT2-1008H Recombinant Human B4GALT2 Protein, His-tagged NS0 His
    Human B4GALT2-8539HCL Recombinant Human B4GALT2 293 Cell Lysate HEK293 N/A
    Mouse B4galt2-11HCL Recombinant Mouse B4galt2 overexpression lysate HEK293T Myc/DDK
    Mouse B4galt2-1807M Recombinant Mouse B4galt2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse B4galt2-27HCL Recombinant Mouse B4galt2 overexpression lysate HEK293T Myc/DDK
    Chicken B4GALT2-6757C Recombinant Chicken B4GALT2 Mammalian Cell His
    Zebrafish B4GALT2-6886Z Recombinant Zebrafish B4GALT2 Mammalian Cell His

    b4galt2 involved in several pathways and played different roles in them. We selected most pathways b4galt2 participated on our site, such as Galactose metabolism, N-Glycan biosynthesis, Other types of O-glycan biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with b4galt2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Galactose metabolism LCT; HK3; G6PCA.1; G6PC; G6PC2; B4GALT2; GALK1; PFKL; GANC; aLA
    N-Glycan biosynthesis B4GALT3; MGAT5; ST6GAL1; MGAT4C; MGAT3A; GANAB; DPM3; ALG13; DPAGT1; MGAT1B
    Other types of O-glycan biosynthesis FUT4; PLOD3; RFNG; B3GAT2; OGT; EOGT; FUT9A; OGT.1; B4GALT1; B3GAT1
    Glycosaminoglycan biosynthesis - keratan sulfate CHST2; ST3GAL1; B3GNT1; CHST6; FUT8A; ST3GAL3B; B3GNT7; B4GALT3; B3GNT2B; ST3GAL3
    Glycosphingolipid biosynthesis - lacto and neolacto series ABO; GCNT2; FUT1; FUT2; B4GALT2; B3GNT2B; B4GALT4; FUT3; GGTA1; ST8SIA1
    Metabolic pathways INPP5K; PI4K2A; NDUFA4L2; PIP5K1BA; CYP19A1; DCXR; DEGS2; NME2; FASN; POLA2

    b4galt2 has several biochemical functions, for example, N-acetyllactosamine synthase activity, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, galactosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by b4galt2 itself. We selected most functions b4galt2 had, and list some proteins which have the same functions with b4galt2. You can find most of the proteins on our site.

    Function Related Protein
    N-acetyllactosamine synthase activity B4GALT1; B4GALT4; B4GALT3; B4GALT2
    beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity B4GALT2; B4GALT3; B4GALT1; WDFY3; B4GALT7
    galactosyltransferase activity B4GALT4; B3GNT9-PS; DPY19L4; 4931440L10Rik; B3GALNT2; GTDC2; B4GALT2; B3GNT8; B3GNTL1; B3GNT7
    lactose synthase activity aLA; B4GALT1; LALBA; B4GALT2
    metal ion binding CYCS; GALNTL2; PDP1; TNNI1; MTMR4; CSGALNACT2; ZNF468; PRICKLE1B; NR6A1A; ZNF649

    b4galt2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with b4galt2 here. Most of them are supplied by our site. Hope this information will be useful for your research of b4galt2.


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