BCAR1

  • Official Full Name

    breast cancer anti-estrogen resistance 1

  • Overview

    BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009]
  • Synonyms

    BCAR1; breast cancer anti-estrogen resistance 1; CAS; CAS1; CASS1; CRKAS; P130Cas; breast cancer anti-estrogen resistance protein 1; Crk-associated substrate p130Cas; Cas scaffolding protein family member 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BCAR1-5042H Recombinant Human BCAR1, His-tagged E.coli His
Human BCAR1-441H Recombinant Human breast cancer anti-estrogen resistance 1, His-tagged E.coli His
Human BCAR1-120H Recombinant Human BCAR1 Protein, GST-tagged Wheat Germ GST
Human BCAR1-121H Recombinant Human BCAR1 Protein, GST-tagged Wheat Germ GST
Human BCAR1-8498HCL Recombinant Human BCAR1 293 Cell Lysate HEK293 N/A
Human BCAR1-4521H Recombinant Human BCAR1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human BCAR1-563H Recombinant Human BCAR1 Protein, His-tagged E.coli His Met1~Leu240
Human BCAR1-430H Recombinant Human BCAR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human BCAR1-1598HF Recombinant Full Length Human BCAR1 Protein, GST-tagged In Vitro Cell Free System GST 870 amino acids
Human BCAR1-1108HFL Recombinant Full Length Human BCAR1 Protein, C-Flag-tagged Mammalian cells Flag
Human BCAR1-430H-B Recombinant Human BCAR1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Bcar1-1840M Recombinant Mouse Bcar1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat BCAR1-950R Recombinant Rat BCAR1 Protein Mammalian Cell His
Rat BCAR1-608R Recombinant Rat BCAR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat BCAR1-608R-B Recombinant Rat BCAR1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish BCAR1-7186Z Recombinant Zebrafish BCAR1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • BCAR1 Related Signal Pathway

BCAR1 involved in several pathways and played different roles in them. We selected most pathways BCAR1 participated on our site, such as Rap signaling pathway, Chemokine signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCAR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rap signaling pathwayPGF;FGFR4;VEGFC;ITGB3;GNAI1;MAP2K3;ITGB2L;PIK3CD;PIK3R2
Chemokine signaling pathwayGM13304;RAC1;PRKCB;CXCL9;CCR3;IKBKG;RAP1A;CCL19;PLCB2
Focal adhesionRAPGEF1;LAMA1;LAMA5;RAF1B;GSK3B;TESK2;COL1A1A;CAPN2B;PXN
Leukocyte transendothelial migrationJAM3;PIK3CB;RHOA;VCL;CDC42;MAPK13;ACTN1;PTPN11;ITGB2
Regulation of actin cytoskeletonPIP5K1AA;BRAF;PAK6B;EZR;FGD;PFN3;ITGAM;RDX;ACTN4
Bacterial invasion of epithelial cellsSEPT2;RAC1;ARPC5;PIK3R1;HCLS1;CLTB;ARPC3;PIK3CD;PTK2

BCAR1 has several biochemical functions, for example, SH3 domain binding, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCAR1 itself. We selected most functions BCAR1 had, and list some proteins which have the same functions with BCAR1. You can find most of the proteins on our site.

Function Related Protein
SH3 domain bindingCIT;PDCD6IP;ADAM15;SH3BP5L;ELMO3;FMN1;DOCK1;VASP;USP8
protein bindingMPZL2;LNX2B;HIST1H2AL;CSNK2B;NAPB;HDC;ANKRD54;ACY3;TBX3
protein kinase bindingPFKFB2;RHOD;STAT3;TRIM5;TRAP1;SKAP1;TNIP2;TBL2;SPDYB
signal transducer activityPTGER1C;S100A9;TAS2R121;ILK;RGS7;MC5RA;MTNR1BB;TRIM13;TAAR13D

BCAR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCAR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCAR1.

PTPN1; CRK; SRC; FYN; PTPN12

Research Area

Related articles

Jardel, P; Debiais, C; et al. Ductal carcinoma of the prostate shows a different immunophenotype from high grade acinar cancer. HISTOPATHOLOGY 63:57-63(2013).
van Agthoven, T; Godinho, MFE; et al. Protein pathway activation mapping reveals molecular networks associated with antiestrogen resistance in breast cancer cell lines. INTERNATIONAL JOURNAL OF CANCER 131:1998-2007(2012).
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