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BCCIP

  • Official Full Name

    BRCA2 and CDKN1A interacting protein

  • Overview

    This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.
  • Synonyms

    BCCIP; BRCA2 and CDKN1A interacting protein; BRCA2 and CDKN1A-interacting protein; BCCIPalpha; TOK 1; BCCIP_HUMAN; BCCIPbeta; BRCA2 and Cip1/p21 interacting protein; Cdk inhibitor p21 binding protein; P21 and CDK associated protein 1; P21- and CDK-associated protein 1; Protein TOK-1; Protein TOK1; TOK 1alpha; TOK 1beta; TOK1; TOK-1beta; TOK-1alpha; TOK-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BCCIP-132H Recombinant Human BCCIP Protein, GST-tagged Wheat Germ GST
Human BCCIP-623H Recombinant Human BCCIP Protein Insect Cell N/A
Human BCCIP-255H Recombinant Human BCCIP, His-tagged E.coli His 1-314aa
Human BCCIP-622H Recombinant Human BCCIP Protein, His&GST-tagged Insect Cell His/GST
Human BCCIP-131H Recombinant Human BCCIP Protein, GST-tagged Wheat Germ GST
Human BCCIP-10171H Recombinant Human BCCIP, GST-tagged E.coli GST 1-314a.a.
Human BCCIP-002HCL Recombinant Human BCCIP cell lysate Insect Cell N/A
Human BCCIP-001HCL Recombinant Human BCCIP cell lysate Insect Cell N/A
Human BCCIP-344HFL Recombinant Full Length Human BCCIP Protein, C-Flag-tagged Mammalian cells Flag
Human BCCIP-434H-B Recombinant Human BCCIP Protein Pre-coupled Magnetic Beads HEK293
Human BCCIP-1610HF Recombinant Full Length Human BCCIP Protein, GST-tagged In Vitro Cell Free System GST 314 amino acids
Human BCCIP-2365H Recombinant Human BCCIP Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human BCCIP-4365H Recombinant Human BCCIP Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human BCCIP-434H Recombinant Human BCCIP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse BCCIP-2328M Recombinant Mouse BCCIP Protein Mammalian Cell His
Mouse Bccip-1845M Recombinant Mouse Bccip Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse BCCIP-982M-B Recombinant Mouse BCCIP Protein Pre-coupled Magnetic Beads HEK293
Mouse BCCIP-982M Recombinant Mouse BCCIP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque BCCIP-519R Recombinant Rhesus monkey BCCIP Protein, His-tagged Mammalian Cell His
Rhesus Macaque BCCIP-347R-B Recombinant Rhesus Macaque BCCIP Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque BCCIP-347R Recombinant Rhesus Macaque BCCIP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish BCCIP-2156Z Recombinant Zebrafish BCCIP Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BCCIP Related Articles

BCCIP involved in several pathways and played different roles in them. We selected most pathways BCCIP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with BCCIP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

BCCIP has several biochemical functions, for example, kinase regulator activity, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCCIP itself. We selected most functions BCCIP had, and list some proteins which have the same functions with BCCIP. You can find most of the proteins on our site.

Function Related Protein
kinase regulator activityGSTP1;BCCIP
poly(A) RNA bindingFAM98C;POP7;ZFC3H1;KIAA0020;PPIA;C1orf131;DNAJC2;SSBP1;UBE2N
protein bindingSORBS3;CYBA;MBD3;SGTB;HIST1H3G;PAK1IP1;KCNE1;USP12;SENP1

BCCIP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCCIP here. Most of them are supplied by our site. Hope this information will be useful for your research of BCCIP.

RPL23; 80125; CTNNB1; EIF6; PRKAB1; ABCB1; PTN; CAPZB; CSNK2B; FAM46A; HIST1H2BN; ITSN2; pi3p; Itsn2; Srp72

Wyler, E; Wandrey, F; et al. The beta-isoform of the BRCA2 and CDKN1A(p21)-interacting protein (BCCIP) stabilizes nuclear RPL23/uL14. FEBS LETTERS 588:3685-3691(2014).
Liu, XX; Cao, LL; et al. Differential BCCIP gene expression in primary human ovarian cancer, renal cell carcinoma and colorectal cancer tissues. INTERNATIONAL JOURNAL OF ONCOLOGY 43:1925-1934(2013).
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