BCL2L11

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BCL2L11

Official Full Name BCL2-like 11 (apoptosis facilitator)
Background Bim (bcl-2-interacting mediator of cell death) is a proapoptotic member of the Bcl-2 family that shares only the BH3 domain with this family. There are three isoforms of Bim: BimEL, BimL, and BimS. Bim is involved in regulating the intrinsic mitochondrial apoptotic pathway by inducing cytochrome c release, which in turn, activates caspase-9 and then caspase-3. Bim also plays a critical role in central and peripheral deletion of T lymphocytes and in controlling B cell homeostasis and activation. BimEL, the long isoform of Bim, is a ~28 kDa protein that is predominantly expressed in T and B cells and is activated by ERK1/2 pathway. The activation of BimEL by ERK1/2 promotes its phosphorylation on serine 65 (serine 69 in human), targeting it for degradation via the proteasome.
Synonyms BCL2L11; BCL2-like 11 (apoptosis facilitator); bcl-2-like protein 11; bcl2-L-11; Bcl2 interacting mediator of cell death; bcl2-interacting mediator of cell death; Bim; Bod; 1500006F24Rik
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BCL2L11-133H Recombinant Human BCL2L11, His tagged E.coli His
    Human BCL2L11-150H Recombinant Human BCL2L11 Protein, GST-tagged Wheat Germ GST
    Human BCL2L11-151H Recombinant Human BCL2L11 Protein, GST-tagged Wheat Germ GST
    Human BCL2L11-1525H Recombinant Human BCL2L11 protein, His-tagged Yeast His
    Human BCL2L11-1578H Recombinant Human BCL2-Like 11 (Apoptosis Facilitator) E.coli N/A
    Human BCL2L11-26430TH Recombinant Human BCL2L11 protein, GST-tagged Wheat Germ GST
    Human BCL2L11-572H Recombinant Human BCL2L11 Protein, His-tagged E.coli His
    Human BCL2L11-60HCL Recombinant Human BCL2L11 lysate HEK293 N/A
    Human BCL2L11-6967H Recombinant Human BCL2-Like 11 (apoptosis facilitator), His-tagged E.coli His
    Mouse BCL2L11-2344M Recombinant Mouse BCL2L11 Protein Mammalian Cell His
    Rat BCL2L11-960R Recombinant Rat BCL2L11 Protein Mammalian Cell His
    Zebrafish BCL2L11-7198Z Recombinant Zebrafish BCL2L11 Mammalian Cell His

    BCL2L11 involved in several pathways and played different roles in them. We selected most pathways BCL2L11 participated on our site, such as Activation of BH3-only proteins, Activation of BIM and translocation to mitochondria, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL2L11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of BH3-only proteins BCL2L11; DYNLL2; E2F1; YWHAQ; CDK5RAP2; AKT3
    Activation of BIM and translocation to mitochondria BCL2L11
    Apoptosis NFKBIAB; BIRC2; IL3; DSP; PIK3R5; PRKAR1B; BIDA; BADB; PIK3R3B; NTRK1
    Apoptosis Modulation and Signaling PTRH2; BLK; HRK; BOK; SEPT4; HN1; CRADD; PTPN13; BCL2L11; DAXX
    B Cell Receptor Signaling Pathway VAV2; ACTR2; CDK7; PRKCB; SOS1; ARPC5; BANK1; INPP5D; PIK3CG; VAV1
    BDNF signaling pathway EIF4E; CNR1; KCNN2; EGR1; IGF2BP1; EIF4EBP1; YBX1; JAK2; CSNK2A1P; CSNK2A1
    BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members BCL2L11
    Cell death signalling via NRAGE, NRIF and NADE ITGB3BP; PLEKHG2; ARHGEF18A; FGD2; ABR; AKAP13; ARHGEF16; ARHGAP4; TIAM2; ECT2

    BCL2L11 has several biochemical functions, for example, contributes_to microtubule binding, microtubule binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL2L11 itself. We selected most functions BCL2L11 had, and list some proteins which have the same functions with BCL2L11. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to microtubule binding BCL2L11
    microtubule binding APC2; CAMSAP1B; DNM2; DPYSL5A; JAKMIP1; FGF13; KIF3C; PEX14; MAPRE3B; MAP1B
    protein binding STK4; SERPINB5; SMAD7; PRPF3; TMEM30A; RFX3; SIVA1; PDGFRA; Txn1; DOK6

    BCL2L11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL2L11 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL2L11.

    MCL1; BCL2L1

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