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Official Full Name bradykinin receptor B2
Background This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008]
Synonyms BDKRB2; bradykinin receptor B2; B2R; BK2; BK-2; BKR2; BRB2; B2 bradykinin receptor; BK-2 receptor;
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Kit-0868 S-Glutathionylated Protein Detection Kit N/A
    Human BDKRB2-155H Recombinant Human BDKRB2 Mammalian Cell His
    Human BDKRB2-185H Recombinant Human BDKRB2 Protein, GST-tagged Wheat Germ GST
    Human BDKRB2-186H Recombinant Human BDKRB2 Protein, GST-tagged Wheat Germ GST
    Cynomolgus Monkey BDKRB2-341C Recombinant Cynomolgus BDKRB2 Protein, His-tagged Mammalian Cell His
    Chicken BDKRB2-3197C Recombinant Chicken BDKRB2 Mammalian Cell His
    Kit-1128 BDKRB2 CHO-K1 β-Arrestin GPCR Assay Kit N/A

    bdkrb2 involved in several pathways and played different roles in them. We selected most pathways bdkrb2 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with bdkrb2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling pathway ATP2A3; ADRA1D; PPIFB; ORAI1B; AGTR1B; TACR3A; CAMK4; SPHK2; PLCD3; TNNC2
    cGMP-PKG signaling pathway FXYD2; MEF2C; GUCY1A3; PIK3R3; NFATC2; INS1; OPRD1; SLC25A6; CALM1; IRS1
    Sphingolipid signaling pathway SPTLC3; PIK3R3; PPP2R3A; PLCB4; PPP2R5A; PPP2R2A; PRKCZ; MAPK3; LASS5; AKT2
    Neuroactive ligand-receptor interaction S1PR5; TACR2; TAAR12G; TAAR10D; HTR7; TACR1B; VIPR1B; GLRA3; GHSRA; TAAR1
    Complement and coagulation cascades C1R; C6; SERPINA5; C3; C1QC; CFI; CR2; SERPING1; C5; PROC
    Inflammatory mediator regulation of TRP channels PRKCQ; CALM1; PLCB2; PRKACG; ASIC3; ACCN3; PIK3CA; MAP2K6; PLCB1; PLCB4
    Regulation of actin cytoskeleton PAK1; ITGAV; FGF22; CYFIP1; MYH9; FGF9; WASLA; GNA12A; MYLPFB; PIKFYVE
    Endocrine and other factor-regulated calcium reabsorption KL; PLCB4; CALB1; PRKCG; PLCB1; PLCB2; ATP1B3; ESR1; KLK1; GNAS
    Chagas disease (American trypanosomiasis) CFLAR; C3; C1QA; GNA14; GNAS; MAPK13; Fasl; IRAK1; PPP2R1A; TNFRSF1A
    Pathways in cancer PRKACA; FLT3; PRKACB; GNAI2; SMAD3; TGFB1; RAF1; GNB1; MMP9; VHL

    bdkrb2 has several biochemical functions, for example, beta-2 adrenergic receptor binding, bradykinin receptor activity, phosphatidylinositol phospholipase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by bdkrb2 itself. We selected most functions bdkrb2 had, and list some proteins which have the same functions with bdkrb2. You can find most of the proteins on our site.

    Function Related Protein
    beta-2 adrenergic receptor binding PDE4D; GNAS; NEDD4; BDKRB2; SLC9A3R1
    bradykinin receptor activity BDKRB2; BDKRB1
    phosphatidylinositol phospholipase C activity PLCD4; CHRM5; PLCG2; CCR1; BDKRB2; PLCD3A; EDNRA; CCKBR; PLCD1; PLCL2
    protease binding ECM1; F3; COMP; TIMP4; ADAMTSL4; SERPINA1; SERPINE1; SERPINA5; RYR1; STIM1
    protein binding MOBKL1A; MARVELD2; C10orf62; CUTC; DIS3L2; MASP2; DOCK4; ASTE1; ARNTL1B; ARHGAP33
    protein heterodimerization activity H3F3A; HIST1H4C; MEF2C; UGT1A4; PRMT8; TOP2A; KCNIP1; UGT1A1; IRAK1; NFYC
    type 1 angiotensin receptor binding GNA13A; AGT; GNG3; TYK2; ARAP1; ARRB2; GNB1; JAK2; BDKRB2; GNA13

    bdkrb2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with bdkrb2 here. Most of them are supplied by our site. Hope this information will be useful for your research of bdkrb2.

    npc-567; KNG1

    Veljkovic, V; Glisic, S; et al. Influenza vaccine as prevention for cardiovascular diseases: Possible molecular mechanism. VACCINE 32:6569-6575(2014).
    Marketou, ME; Kontaraki, J; et al. Differential gene expression of bradykinin receptors 1 and 2 in peripheral monocytes from patients with essential hypertension. JOURNAL OF HUMAN HYPERTENSION 28:450-455(2014).

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