BIK

  • Official Full Name

    BCL2-interacting killer (apoptosis-inducing)

  • Overview

    Bik/Nbk (Bcl-2-interacting killer/natural born killer) is a potent pro-apoptotic protein belonging to a group of Bcl-2 family members that includes Bad, Bid, Bim, Hrk, and Noxa, containing a BH3 domain but lacking other conserved domains, BH1 or BH2. Func
  • Synonyms

    BIK; BCL2-interacting killer (apoptosis-inducing); bcl-2-interacting killer; NBK; apoptosis inducer NBK; apoptosis-inducing NBK; BP4; BIP1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • Fc
  • Avi
  • Non
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BIK-219H Recombinant Human BIK Protein, GST-tagged Wheat Germ GST
Human BIK-769H Recombinant Human BIK Protein, His-tagged E.coli His
Human BIK-220H Recombinant Human BIK Protein, GST-tagged Wheat Germ GST
Human BIK-65HCL Recombinant Human BIK lysate HEK293 Non
Human BIK-1626HF Recombinant Full Length Human BIK Protein, GST-tagged In Vitro Cell Free System GST 160 amino acids
Mouse BIK-2405M Recombinant Mouse BIK Protein Mammalian Cell His
Mouse BIK-1033M Recombinant Mouse BIK Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Mouse BIK-1033M-B Recombinant Mouse BIK Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL31368HF Recombinant Full Length Human Bcl-2-Interacting Killer(Bik) Protein, His-Tagged E.coli expression system His Full Length (1-160)
Zebrafish BIK-4106Z Recombinant Zebrafish BIK Mammalian Cell His
Chicken BIK-5334C Recombinant Chicken BIK Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

BIK involved in several pathways and played different roles in them. We selected most pathways BIK participated on our site, such as Apoptosis Modulation and Signaling, DNA damage response (only ATM dependent), which may be useful for your reference. Also, other proteins which involved in the same pathway with BIK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Apoptosis Modulation and SignalingCAPNS1;BCL2L11;PTPN13;HRK;PTRH2;SEPT4;BOK;DIABLO;DFFA
DNA damage response (only ATM dependent)DVL1;BIK;DVL2;DVL3;MLKL

BIK has several biochemical functions, for example, BH domain binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BIK itself. We selected most functions BIK had, and list some proteins which have the same functions with BIK. You can find most of the proteins on our site.

Function Related Protein
BH domain bindingBOK;BCL2L2;BCL2A1A;BAK1;Bcl2a1b;BIK
protein bindingNDE1;RAB27A;MMP2;KRT25;RAB5C;EIF2S3;ACAA1;SPATA8;MAGEA9
protein heterodimerization activityNR4A1;Fzd4;TXLNG;PRSS28;CAV1;ADD1;MCL1;HIST1H2BK;ENO3

BIK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIK here. Most of them are supplied by our site. Hope this information will be useful for your research of BIK.

BCL2L2; BCL2; FATE1; BCL2L1; BCL2L1; BCL2A1

Research Area

Related articles

Albrechtsen, R; Kveiborg, M; et al. ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis and increased tumor growth. JOURNAL OF CELL SCIENCE 126:4707-4720(2013).
Sung, ES; Park, KJ; et al. The proteasome inhibitor MG132 potentiates TRAIL receptor agonist-induced apoptosis by stabilizing tBid and Bik in human head and neck squamous cell carcinoma cells. EXPERIMENTAL CELL RESEARCH 318:1564-1576(2012).
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