BRAF
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Official Full Name
v-raf murine sarcoma viral oncogene homolog B1
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Overview
The Raf proteins are a family of serine/threonine-specific kinases that serve as a central intermediate in transmitting extracellular signals to the mitogen-activated protein kinase cascade, which controls cell growth, differentiation and survival. Three -
Synonyms
BRAF; v-raf murine sarcoma viral oncogene homolog B1; serine/threonine-protein kinase B-raf; BRAF1; p94; 94 kDa B-raf protein; proto-oncogene B-Raf; murine sarcoma viral (v-raf) oncogene homolog B1; B-Raf proto-oncogene serine/threonine-protein kinase (p9;
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- Involved Pathway
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- Interacting Protein
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BRAF involved in several pathways and played different roles in them. We selected most pathways BRAF participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRAF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | TNFRSF1A;FLNA;IL1R2;PDGFAA;TRAF2;HRAS;CDC42L2;AKT1;MAP2K2 |
| ErbB signaling pathway | CAMK2B;PIK3R5;SHC2;AKT3A;AKT2L;PAK3;RPS6KB1;SHC1;MAP2K2A |
| Rap signaling pathway | RAPGEF5;DOCK4;SKAP1;VASP;PLCB4;ITGAL;ARAP3;CALML5;APBB1IP |
| cAMP signaling pathway | ATP2B4;FSHB;PTGER2;MAP2K1;GIPR;GRIN2C;RAC3;GABBR1;RAC2 |
| Chemokine signaling pathway | VAV1;CXCR3;CCL14;CCL11;RELA;PIK3CA;CCL7;GRK4;ADRBK2 |
| FoxO signaling pathway | GADD45B;MAPK8B;PIK3R3;FOXO1A;RAG1;PRKAB2;GRB2B;ARAF;MAPK13 |
| mTOR signaling pathway | CAB39L;EIF4E2RS1;RPS6KA3A;RPS6;TSC2;PRKCBB;PIK3CB;IRS1;MAPK1 |
| Vascular smooth muscle contraction | GUCY1B3;NPR1;PRKACBB;ADRA1BB;PPP1R14A;PRKACB;MAPK1;PRKCG;MLCK2 |
| Focal adhesion | ITGA3B;MYL7;RAC3;TNC;PIK3R1;THBS3A;MYLK;ITGB5;VCL |
| Natural killer cell mediated cytotoxicity | Raet1a;LCK;PTK2B;RAC3;KLRA8;IFNAR2;VAV2;FCGR3;TNFRSF10D |
| Long-term potentiation | CALML3;CAMK2D;MAP2K1;RPS6KA2;PPP3CB;BRAF;GRM1;PPP1R1A;PLCB4 |
| Neurotrophin signaling pathway | RHOA;MAP2K2;MAPK10;NTRK3;ARHGDIA;MAPK1;RIPK2;RELA;MAPK8 |
| Serotonergic synapse | GNAI3;CYP2J5;GNG5;SLC18A2;GNB4;PTGS1;CYP4X1;GNG2;CYP2C50 |
| Long-term depression | PRKCG;PLCB3;PPP2R1B;PPP2R1A;IGF1;PLA2G4C;NRAS;GRIA3;PPP1R17 |
| Regulation of actin cytoskeleton | CYFIP2;PDGFA;ITGAV;ITGB5;FGF5;PFN1;ITGA8;ROCK2B;FGF10A |
| Insulin signaling pathway | PRKAR1A;FASN;EIF4E1B;EIF4E2RS1;PHKA1;PPP1CA;PTPN1;GYS2;RPS6KB1 |
| Progesterone-mediated oocyte maturation | MAPK8A;ANAPC13;CDC25C;IGF1RB;MAPK12A;CDC23;RAF1B;AKT1;RAF1A |
| Alcoholism | H2BFWT;H2AFB3;RAF1;HIST1H2AA;HIST1H4F;GNG2;H2AFX;HIST1H3C;SLC18A1 |
| Hepatitis C | OSTN;TLR3;RXRA;PPP2R2D;TP53;TRADD;OAS1A;IFNA12;PPP2R2C |
| Pathways in cancer | GNB2;FGF6;NRAS;Kitl;FN1;ETS1;PML;PPARG;GLI3 |
| Proteoglycans in cancer | TLR2;GRB2;PPP1R12A;FLNC;MAPK1;PTCH1;ROCK2;STAT3;PPP1CA |
| Colorectal cancer | TGFBR2;SMAD2;PIK3R1;APC;APPL1;APC2;PIK3R5;RHOA;PIK3R2 |
| Renal cell carcinoma | RAP1B;HRAS;RAC1;HGF;VEGFA;MAPK1;HIF1A;PIK3R3;PAK2 |
| Pancreatic cancer | AKT1;VEGFA;PIK3CA;RALB;RAD51;ERBB2;MAPK10;SMAD3;BRCA2 |
| Endometrial cancer | AXIN2;PIK3R3;TRP53;PIK3R5;LEF1;AXIN1;CTNNA2;AKT1;APC |
| Glioma | SHC3;PDGFA;MAP2K1;GRB2;PIK3R3;BRAF;PIK3R5;Pdgfa&Pdgfb;RAF1 |
| Prostate cancer | PDPK1;TCF7;FOXA1;Ar;PTEN;GSTP1;PIK3CA;MAP4K1;HSP90AB1 |
| Thyroid cancer | TPM3;CCND1;RXRB;LEF1;TPR;MAP2K1;TP53;MAP2K2;TCF7 |
| Melanoma | PIK3CA;AKT2;KRAS;PTEN;FGF8;PIK3R2;PDGFRA;NRAS;MAP2K1 |
| Bladder cancer | MMP9;RPS6KA5;MMP2;HBEGF;MDM2;MAPK3;TYMP;KRAS;IL-8 |
| Chronic myeloid leukemia | SMAD3;RB1;NFKBIA;RELA;STAT5B;TGFB1;PIK3CB;MAPK1;PIK3CD |
| Acute myeloid leukemia | AKT1;SFPI1;AKT2;CCND1;PML;NRAS;IKBKB;NFKB1;MAP2K2 |
| Non-small cell lung cancer | ERBB2;RXRG;TRP53;STK4;MAP2K2;PIK3CB;CASP9;RASSF5;BAD |
BRAF has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRAF itself. We selected most functions BRAF had, and list some proteins which have the same functions with BRAF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | GKUP;HSP90AB1;EIF4A3;LATS2;RUNX2;UCK2B;RYK;ERCC6L;FLJ11011L |
| MAP kinase kinase kinase activity | MAP3K2;MAP3K12;MAP3K4;MAP3K1;MAP3K13;ALPK2;MAP3K8;TAOK3;EGFR |
| calcium ion binding | PCDH1GC5;MICU2;CDH7;CAPSL;GUCA1A;LRP1;PCDH2G10;SYT5A;JAG1B |
| identical protein binding | CEP57L1;HOOK2;EWSR1;SNRNP200;PPP5C;BCHE;CLDND;NONO;AGER |
| mitogen-activated protein kinase kinase binding | DLG1;TRIB3;TAOK2;MAPK8IP3;MAP3K11;RAF1;TRIB2;KSR1;PIN1 |
| protein binding | PGM1;HP;YARS2;KRT86;BAG4;EIF3M;CD200R2;SCARB2;RAB8B |
| protein heterodimerization activity | SOX9;JDP2;PPP1CBL;CRLF1;MCL1B;GCLC;ATF4;HIST1H2AF;HAND1 |
| protein kinase activity | MAP3K1;GM4922;CAMKV;CDK17;CDK5;IGF1RB;CLK4B;CDK11B;TLK1A |
| protein serine/threonine kinase activity | GSK3A;TSSK5;TSSK2;SLK;CSNK1G2B;PKZ;STK17A;HIPK2;PRKD2 |
| NOT small GTPase binding | BRAF;RAF1 |
BRAF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRAF here. Most of them are supplied by our site. Hope this information will be useful for your research of BRAF.
MAP2K1
Research Area
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Q&As (1)
Ask a questionIf the product is used in Japan and falls under the Cartagena Law, it needs to be controlled appropriately.
BRAF-550H 04/15/2023
This protein is not a living modified organism, so it does not apply to the Cartagena Law in Japan. No worries.
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