BRAF
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Official Full Name
v-raf murine sarcoma viral oncogene homolog B1 -
Overview
The Raf proteins are a family of serine/threonine-specific kinases that serve as a central intermediate in transmitting extracellular signals to the mitogen-activated protein kinase cascade, which controls cell growth, differentiation and survival. Three -
Synonyms
BRAF;v-raf murine sarcoma viral oncogene homolog B1;serine/threonine-protein kinase B-raf;BRAF1;p94;94 kDa B-raf protein;proto-oncogene B-Raf;murine sarcoma viral (v-raf) oncogene homolog B1;B-Raf proto-oncogene serine/threonine-protein kinase (p9
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- HEK293
- Sf9 Cells
- Wheat Germ
- Insect Cells
- Mammalian Cells
- Sf21 Cells
- E.coli
- Insect cells
- Protein Conjugation
- DDK
- Myc
- GST
- His
- Flag
- Non
- Avi
- Fc
Involved Pathway
BRAF involved in several pathways and played different roles in them. We selected most pathways BRAF participated on our site, such as MAPK signaling pathway,ErbB signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRAF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endometrial cancer | MAPK1,PIK3R3,MAP2K2,AXIN2,PIK3R5,CCND1,PIK3CA,TCF7,PIK3CD,AKT2 |
| Bladder cancer | CDH1,FGFR3,MAPK3,HRAS,CDK4,KRAS,THBS1,EGF,TRP53,E2F3 |
| FoxO signaling pathway | SOD2,IGF1RA,MAPK14B,RAG1,SGK3,PRKAG3,PLK4,STK4,PIK3R1,NLK2 |
| Regulation of Actin Cytoskeleton | ACTN3B,PPP1CBL,FGF18,ROCK2B,PDGFRA,FGF10,PPP1R12A,RHOAD,FGF17,ITGA6 |
| Glioma | PDGFA,PIK3R1,PDGFB,SHC1,CALM3,PDGFRB,PIK3CG,CALML5,IGF1,CALM4 |
| Acute myeloid leukemia | RUNX1T1,ARAF,KRAS,RAF1,PML,PIM1,RPS6KB1,SPI1,NFKB1,CHUK |
| Chemokine signaling pathway | PLCB4,HCK,CCL18,CRK,Ccl21a,CCL21B,CCL2,PIK3CD,Cxcl15,VAV2 |
| Melanoma | Pdgfa&Pdgfb,RAF1,HGF,FGF2,CDH1,FGF13,RB1,FGF7,FGF22,FGF20 |
| Focal adhesion | FN1A,ITGA2B,SHC1,PRKCBB,COL5A2,MYLK,ITGA6,COL11A2,PTEN,COL4A6 |
Protein Function
BRAF has several biochemical functions, for example, ATP binding,MAP kinase kinase kinase activity,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRAF itself. We selected most functions BRAF had, and list some proteins which have the same functions with BRAF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | UBE2F,ATP7A,HK1,NETO2,C9orf96,CIT,STK40,MAT2AL,ATP1A1A.4,EPHB2B |
| MAP kinase kinase kinase activity | MAP3K5,TAOK1,TAOK3,MAP3K6,MAP3K13,MAP3K15,MAP3K1,STK4,MAP3K2,MOS |
| protein serine/threonine kinase activity | FAM20C,PAK2,PLK3,ACVR1L,SQSTM1,TTK,DYRK1B,PRKCD,VPRBP,KALRN |
| protein kinase activity | PRKACBA,TNIKA,COL4A3BP,NEK12,MAPKAPK2A,PDGFRA,RPS6KB2,MAP3K14,CAMKK1A,PRKDC |
| identical protein binding | FXR2,DAPK2,CLDN1,SOD2,DYNLT1F,ADIPOR1,TRIM23,MAPK1IP1,BIRC5,SQSTM1 |
| mitogen-activated protein kinase kinase binding | TRIB3,IGBP1,MAP3K11,TRIB2,ARRB1,MAPK8IP3,RAF1,TAOK2,TRIB1,PIN1 |
| protein binding | FRG1,AZIN2,AGBL1,SNCA,FLII,NUFIP2,PARK2,DLC1,NOTCH2,P4HB |
| calcium ion binding | PCDH2AB11,MMP19,GCH1,CALB2A,PLCD3A,CCDC167,CAPSLB,S100A10,HSP90B1,ANXA2A |
| protein heterodimerization activity | MYH7,NFYB,SDCBP2,PPP3CB,RXRA,APOA2,AHR,HER11,NFKB1,TCF3B |
Interacting Protein
BRAF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRAF here. Most of them are supplied by our site. Hope this information will be useful for your research of BRAF.
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References
- Johnson, DB; Peng, CW; et al. Nivolumab in melanoma: latest evidence and clinical potential. THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY 7:97-106(2015).
- Bellizzi, AM; et al. Screening for Lynch Syndrome: A No-Brainer BRAF V600E Mutation-Specific Immunohistochemistry: Caveat Emptor. AMERICAN JOURNAL OF CLINICAL PATHOLOGY 143:320-324(2015).
