BRAF
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Official Full Name
v-raf murine sarcoma viral oncogene homolog B1 -
Overview
The Raf proteins are a family of serine/threonine-specific kinases that serve as a central intermediate in transmitting extracellular signals to the mitogen-activated protein kinase cascade, which controls cell growth, differentiation and survival. Three -
Synonyms
BRAF;v-raf murine sarcoma viral oncogene homolog B1;serine/threonine-protein kinase B-raf;BRAF1;p94;94 kDa B-raf protein;proto-oncogene B-Raf;murine sarcoma viral (v-raf) oncogene homolog B1;B-Raf proto-oncogene serine/threonine-protein kinase (p9
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- HEK293
- Sf9 Cells
- Wheat Germ
- Insect Cells
- Mammalian Cells
- Sf21 Cells
- E.coli
- Insect cells
- Protein Conjugation
- DDK
- Myc
- GST
- His
- Flag
- Non
- Avi
- Fc
Involved Pathway
BRAF involved in several pathways and played different roles in them. We selected most pathways BRAF participated on our site, such as MAPK signaling pathway,ErbB signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRAF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of Actin Cytoskeleton | ITGAX,FGF17,MSN,ITGB2,ITGB1B.2,PPP1R12B,FGF1A,CDC42L,PFN2L,LIMK1 |
| Chemokine signaling pathway | PIK3CG,CCL27,FOXO3,WASL,GNAI2,ROCK1,CCL24,GNG3,ARRB1,GNG7 |
| Neurotrophin signaling pathway | BDNF,SH2B1,GAB1,CALM1,ARHGDIA,RAC1,RAP1A,BAD,MAPK3,SH2B3 |
| Renal cell carcinoma | PIK3CA,KRAS,EGLN2,ARNT2,PAK6,PIK3CB,PAK1,ETS1,TGFA,FH |
| Glioma | PIK3CD,PDGFRA,AKT1,SHC2,PRKCG,HRAS,PIK3R5,PIK3R2,Pdgfa&Pdgfb,MAPK1 |
| Rap signaling pathway | Fgf15,RAC1,MAPK3,LPAR4,RRAS,ID1,CDH1,RAPGEF5,RALGDS,PFN1 |
| Pancreatic cancer | PIK3CA,CASP9,VEGFA,BRCA2,TGFB3,RAC2,NFKB1,STAT3,RELA,TGFBR2 |
| Progesterone-mediated oocyte maturation | ANAPC11,ARAF,RPS6KA3B,PIK3R5,ANAPC2,AKT2,PIK3CB,RPS6KA3A,MAPK8A,MAPK12A |
| cAMP signaling pathway | NPY1R,PPP1CC,FXYD2,PRKACA,ORAI1,GRIA3,CNGA3,CALM3,GRIN3A,GRIA2 |
Protein Function
BRAF has several biochemical functions, for example, ATP binding,MAP kinase kinase kinase activity,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRAF itself. We selected most functions BRAF had, and list some proteins which have the same functions with BRAF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| mitogen-activated protein kinase kinase binding | ARRB1,TAOK2,TRIB1,PIN1,KSR1,ACE,TRIB3,TRIB2,MAP3K11,RAF1 |
| MAP kinase kinase kinase activity | MAP3K15,ALPK2,STK4,MAP3K2,EGFR,YSK4,RAF1,MAP3K13,MAP3K8,MAP3K12 |
| protein heterodimerization activity | NPM1,BIK,PDZD7,EFHA1,EXT1,MTTP,BAXA,ZHX3,HIST1H2B5,HIST1H2BP |
| NOT small GTPase binding | RAF1 |
| ATP binding | CLCN4,TK2,HSPA1L,UBE2C,CAMK1G,NMNAT1,CDC34A,MSH4,PCCA,INSRA |
| calcium ion binding | SYT9,FSTL1,PCDH2AB8,SERPINB1A,MYL5,REPS1,ANXA1B,MYL9A,PLCD3A,CETN2 |
| identical protein binding | CREBZF,APOE,PAK2,CEP170L,AGXT2L1,APLP1,FGFR1,AGXT2L2,ZNF212,COL7A1 |
| protein serine/threonine kinase activity | TGFBR1A,BMPR1B,DAPK1,DYRK4,MAPKAPK2,PAK2,CDKL5,CPNE3,NUAK2,STK32B |
| protein kinase activity | STK17B,MAP3K3,TESK2,ABL2,PTK2,MAP3K10,MAPK12B,RAF1A,PRKCDA,MAP3K12 |
Interacting Protein
BRAF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRAF here. Most of them are supplied by our site. Hope this information will be useful for your research of BRAF.
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References
- Johnson, DB; Peng, CW; et al. Nivolumab in melanoma: latest evidence and clinical potential. THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY 7:97-106(2015).
- Bellizzi, AM; et al. Screening for Lynch Syndrome: A No-Brainer BRAF V600E Mutation-Specific Immunohistochemistry: Caveat Emptor. AMERICAN JOURNAL OF CLINICAL PATHOLOGY 143:320-324(2015).
