BRAF

  • Official Full Name

    v-raf murine sarcoma viral oncogene homolog B1

  • Overview

    The Raf proteins are a family of serine/threonine-specific kinases that serve as a central intermediate in transmitting extracellular signals to the mitogen-activated protein kinase cascade, which controls cell growth, differentiation and survival. Three
  • Synonyms

    BRAF; v-raf murine sarcoma viral oncogene homolog B1; serine/threonine-protein kinase B-raf; BRAF1; p94; 94 kDa B-raf protein; proto-oncogene B-Raf; murine sarcoma viral (v-raf) oncogene homolog B1; B-Raf proto-oncogene serine/threonine-protein kinase (p9;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • Baculovirus-Insect cells
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insects cell
  • Mammalian Cell
  • Mammalian cells
  • Protein Conjugation
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • DDK
  • Flag
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • His|Flag
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BRAF-550H Active Recombinant Human BRAF/p50 Protein, Flag-His-tagged Insects cell His/Flag
Human BRAF-791H Active Recombinant Human BRAF protein, GST-tagged Insect Cell GST
Human BRAF-22H Active Recombinant Human BRAF protein, MYC/DDK-tagged HEK293 Myc/DDK
Human BRAF-319H Active Recombinant Human BRAF Protein, GST-His-tagged Sf9 Insect Cell GST/His
Human BRAF-321H Active Recombinant Human BRAF Protein, GST-tagged Wheat Germ GST
Human BRAF-179H Recombinant Human BRAF protein, MYC/DDK-tagged HEK293 Myc/DDK
Human BRAF-26566TH Recombinant Human BRAF N/A
Human BRAF-176H Recombinant Human BRAF protein, DDK-tagged HEK293 DDK
Human BRAF-320H Recombinant Human BRAF Protein, GST-tagged Sf21 Insect Cell GST
Human BRAF-180H Recombinant Human BRAF protein, MYC/DDK-tagged HEK293 Myc/DDK
Human BRAF-175H Recombinant Human BRAF protein, DDK-tagged HEK293 DDK
Human BRAF-178H Recombinant Human BRAF protein, MYC/DDK-tagged HEK293 Myc/DDK
Human BRAF-994H Recombinant Human V-Raf Murine Sarcoma Viral Oncogene Homolog B1, GST-tagged Sf9 Insect Cell GST
Human BRAF-181H Recombinant Human BRAF protein, MYC/DDK-tagged HEK293 Myc/DDK
Human BRAF-177H Recombinant Human BRAF protein, MYC/DDK-tagged HEK293 Myc/DDK
Human BRAF-183H Recombinant Human BRAF protein, MYC/DDK-tagged HEK293 Myc/DDK
Human BRAF-174H Recombinant Human BRAF protein, MYC/DDK-tagged HEK293 Myc/DDK
Human BRAF-182H Recombinant Human BRAF protein, MYC/DDK-tagged HEK293 Myc/DDK
Human BRAF-26567TH Recombinant Human BRAF N/A
Human BRAF-253H Recombinant Human BRAF, GST-tagged, Active Sf9 Insect Cell GST
Human BRAF-8414HCL Recombinant Human BRAF 293 Cell Lysate HEK293 N/A
Human BRAF-328H Recombinant Human BRAF Protein, His-tagged E.coli N-His
Human BRAF-456H-B Recombinant Human BRAF Protein Pre-coupled Magnetic Beads HEK293
Human BRAF-2781H Recombinant Human BRAF Protein, His-tagged, BSA Conjugated Protein Conjugation N-His
Human BRAF-456H Recombinant Human BRAF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human BRAF-2782H Recombinant Human BRAF Protein, His-tagged, BSA Conjugated Protein Conjugation N-His
Human BRAF-1391H Recombinant Human BRAF Protein (500-766), His tagged E.coli His
Human BRAF-68HFL Recombinant Full Length Human BRAF Protein, C-Flag-tagged Mammalian cells Flag
Human BRAF-0217H Recombinant Human BRAF Protein (Full Length), N-His-tagged Baculovirus-Insect cells N-His
Human BRAF-0787H Recombinant Human BRAF Protein (Asn500-His766), N-His tagged E.coli N-His
Mouse BRAF-2477M Recombinant Mouse BRAF Protein Mammalian Cell His
Mouse BRAF-1081M Recombinant Mouse BRAF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse BRAF-1081M-B Recombinant Mouse BRAF Protein Pre-coupled Magnetic Beads HEK293
Mouse Braf-441M Recombinant Mouse Braf Protein, MYC/DDK-tagged HEK293T MYC/DDK
Zebrafish BRAF-11759Z Recombinant Zebrafish BRAF Mammalian Cell His
Chicken BRAF-6854C Recombinant Chicken BRAF Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BRAF Related Articles
  • BRAF Related Research Area

BRAF involved in several pathways and played different roles in them. We selected most pathways BRAF participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRAF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayKCNA3;GADD45G;FAS;PTPN7;PLA2G4F;HSPA2;FGF2;AKT2L;PDGFRB
ErbB signaling pathwayCDKN1BB;MAPK9;PTK2AA;HRASB;NRG1;RPS6KB1;PIK3R3A;PRKCBA;PIK3R3B
Rap signaling pathwayRAC1;ITGA2B;FGF7;CALM2;ACTG1;CALML3;PRKCB;PIK3R5;PDGFA
cAMP signaling pathwayGRIA1;MAPK10;GABBR2;GRIA4;SUCNR1;RRAS2;RAP1B;TSHR;GLI1
Chemokine signaling pathwayCCR1;GNAI3;PRKCZ;ROCK1;PLCB3;CCR1L1;CCL2;DOCK2;IKBKG
FoxO signaling pathwayRBL2;MAPK12;AKT2L;PRKAB1B;PLK1;CDKN1BB;G6PC;PIK3CB;PRKAG3
mTOR signaling pathwayRPS6KA3;AKT3A;EIF4E2RS1;IRS1;AKT1;PIK3R3A;RPS6KA3B;RPS6KAL;PTENA
Vascular smooth muscle contractionMYLK3;AVPR1A;PLA2G4C;PPP1R12B;CALM3A;PRKCDA;GNA15.1;ADORA2AA;PLA2G2D
Focal adhesionERBB2;PIK3CG;COL27A1A;PXN;MYLK;LAMA4;RAF1;PIK3R1;COL6A1
Natural killer cell mediated cytotoxicitySHC2;Raet1c;PTPN6;FCER1G;SOS1;IFNA14;PRKCA;SAMD3;KLRC1
Long-term potentiationPRKCG;CAMK2G;GRIN2B;PRKACB;PRKACG;GRIN2A;PPP3CC;PRKACA;CALM2
Neurotrophin signaling pathwayIKBKB;MAP3K5;PDPK1;RAF1;KIDINS220;PLCG1;PRKCD;MAPK9;CAMK4
Serotonergic synapseMAOB;PTGS1;CYP2D26;GNAI1;GNG13;PLCB4;PLCB1;TPH2;PRKACA
Long-term depressionLYN;PPP2R1B;GNAI1;PPP2CB;ITPR1;MAP2K1;GRIA1;PLA2G4C;RAF1
Regulation of actin cytoskeletonROCK2B;GSN;PPP1CAA;ARHGEF7B;VCLA;FGF19;RHOAC;FGF22;LIMK1A
Insulin signaling pathwayINSRA;PCK1;PRKAG2A;HRASB;PKLR;PYGL;PHKB;FLOT2A;PTPRF
Progesterone-mediated oocyte maturationINS;CDH1-A;ADCY2B;ARAF;GNAI2A;SPDYB;ADCY1A;MAD1L1;PIK3CG
AlcoholismCALM3;CREB3L4;PPP1CC;CALM1;PPP1CA;SLC6A3;CAMKK2;DRD2;HIST1H2AH
Hepatitis CSTAT3;EIF2AK4;BRAF;TYK2;MAPK3;EIF2AK1;EIF3E;IFNA8;EIF2AK3
Pathways in cancerPIK3CA;WNT3A;WNT5A;GNG11;FGF2;SKP2;GLI1;EPAS1;GLI2
Proteoglycans in cancerANK2;TWIST1;FLNC;WNT11;FZD8;TFAP4;CTTN;ITGA5;PRKACB
Colorectal cancerMLH1;AKT2;BRAF;MSH2;BAX;AXIN2;TGFBR1;SMAD2;MSH3
Renal cell carcinomaPIK3R5;RAPGEF1;EGLN2;NRAS;ARAF;AKT2;CUL2;HRAS;AKT1
Pancreatic cancerCASP9;TGFB3;RAC1;PLD1;MAP2K1;RALBP1;AKT1;IKBKG;SMAD2
Endometrial cancerAXIN2;CASP9;APC2;NRAS;ARAF;BRAF;PDPK1;MLH1;AKT2
GliomaIGF1;CALM1;MDM2;CALML3;PRKCB;PDGFB;PDGFA;RAF1;PLCG1
Prostate cancerACTL6B;SMARCD1;HSP90AB1;CREB3L1;GSTP1;FGFR2;MAPK1;CCNE2;INS1
Thyroid cancerTPR;LEF1;TCF7;CDH1;KRAS;PAX8;CCDC6;MAPK1;HRAS
MelanomaCDH1;Fgf15;FGF8;FGF16;IGF1;FGF1;FGF20;PIK3CD;PIK3R1
Bladder cancerE2F2;IL-8;MAP2K2;DAPK3;MMP2;DAPK1;RB1;HRAS;MAPK3
Chronic myeloid leukemiaPIK3CA;CBLC;STAT5A;CTBP2;PTPN11;TGFBR2;RAF1;GAB2;PIK3CD
Acute myeloid leukemiaSOS1;PIK3CD;RUNX1;RPS6KB2;PIK3R1;CCND1;NFKB1;EIF4EBP1;STAT3
Non-small cell lung cancerRXRG;PIK3CD;PLCG2;RASSF1;STK4;PIK3CA;RXRA;BAD;TGFA

BRAF has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRAF itself. We selected most functions BRAF had, and list some proteins which have the same functions with BRAF. You can find most of the proteins on our site.

Function Related Protein
ATP bindingTOR1L3;NME6;KTI12;CSNK1E;CERK;EPHA8;HSPA4L;TBK1;ATP2C2
MAP kinase kinase kinase activityMAP3K3;MAP3K12;BRAF;MAP3K8;TAOK1;EGFR;MAP3K13;MAP3K15;MAP3K5
calcium ion bindingJAG1;MYL9A;GAS6;ENPP2;NELL2A;MMP25;PCDH1GB9;S100B;EGFL6
identical protein bindingPHYKPL;RYR2;PHC2;SSNA1;ATF3;SMAD1;VPS41;CCL3;NUFIP1
mitogen-activated protein kinase kinase bindingACE;RAF1;MAPK8IP3;TAOK2;TRIB3;MAP3K11;PIN1;TRIB1;BRAF
protein bindingTNNI2;CALU;CRMP1;KCNA1;SCRIB;NAT2;ADAM10;SNAP29;SRPX2
protein heterodimerization activityH2AFZ;BOK;POLA2;MPP7;RALGAPA1;P2RY1;NEFL;Bcl2a1b;TPD52L2
protein kinase activityGC3;CAMKK1A;MMD2;MAP3K11;GM4922;GSK3AB;ROCK1;SBK1;PRKAA1
protein serine/threonine kinase activityNLK2;PKZ;NEK3;TSSK6;PRKDC;MAP2K4;SRPK1B;RIPK4;BUB1B
NOT small GTPase bindingBRAF;RAF1

BRAF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRAF here. Most of them are supplied by our site. Hope this information will be useful for your research of BRAF.

MAP2K1

Johnson, DB; Peng, CW; et al. Nivolumab in melanoma: latest evidence and clinical potential. THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY 7:97-106(2015).
Bellizzi, AM; et al. Screening for Lynch Syndrome: A No-Brainer BRAF V600E Mutation-Specific Immunohistochemistry: Caveat Emptor. AMERICAN JOURNAL OF CLINICAL PATHOLOGY 143:320-324(2015).
  • Q&As
  • Reviews

Q&As (1)

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Please let us confirm whether or not the following kinase products marketed by your company are products applicable to the Cartagena Law in Japan.
If the product is used in Japan and falls under the Cartagena Law, it needs to be controlled appropriately.
BRAF-550H 04/15/2023

This protein is not a living modified organism, so it does not apply to the Cartagena Law in Japan. No worries.

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