CACNB2
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Official Full Name
calcium channel, voltage-dependent, beta 2 subunit -
Overview
This gene encodes a subunit of a voltage-dependent calcium channel protein which is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome which is an autoimmune disorder. Mutations in this gene are associated with Brugada symdrome. Alternatively spliced variants have been identified for this gene. -
Synonyms
CACNB2;calcium channel, voltage-dependent, beta 2 subunit;CACNLB2, MYSB;voltage-dependent L-type calcium channel subunit beta-2;CAB2;lambert-Eaton myasthenic syndrome antigen B;myasthenic (Lambert-Eaton) syndrome antigen B;calcium channel voltage-d
Recombinant Proteins
- Human
- Rat
- Rhesus macaque
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- His
- GST
- Non
- Avi
- Fc
Involved Pathway
CACNB2 involved in several pathways and played different roles in them. We selected most pathways CACNB2 participated on our site, such as MAPK signaling pathway,Cardiac muscle contraction,Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ITGB8,DMD,CACNG4,CACNA2D3,ITGA4,PKP2,DSP,DSG2,SGCB,CACNA2D4 |
| Adrenergic signaling in cardiomyocytes | PPP2R5D,GNAI2A,PPP2R3A,CALML5,CACNG1A,ADRA1B,ADCY8,MYH7,ATP1B1,PIK3CB |
| Cardiac muscle contraction | CACNB1,CACNG4,COX5AA,CACNG2A,SLC8A1,ACTC1A,TPM4,UQCRH,CACNA2D1A,CACNG7 |
| Oxytocin signaling pathway | PRKCG,NOS3,NFATC1,MYL6B,PPP1CA,PLA2G4C,NPR2,ROCK2,RYR2,NFATC3 |
| MAPK signaling pathway | PRKACA,PPP5C,FLNC,MAPK14A,RAC2,GNA12A,RAC1A,PTPRR,RELB,GADD45B |
| Dilated cardiomyopathy | ITGAV,ITGB8,CACNB1,CACNG8,TGFB3,TNF,CACNG4,MYL2,MYL3,RYR2 |
| Hypertrophic cardiomyopathy (HCM) | TNF,ITGA6,SLC8A1,SGCB,TGFB1,PRKAB2,ITGA9,PRKAG1,ITGA7,TNNI3 |
Protein Function
CACNB2 has several biochemical functions, for example, calcium channel activity,calcium channel regulator activity,contributes_to high voltage-gated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNB2 itself. We selected most functions CACNB2 had, and list some proteins which have the same functions with CACNB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium channel activity | SLC24A2,TRPV6,TRPC5A,TMEM37,UBXN6,P2RX1,TRPC7A,TRPC3,CATSPER2,PANX1 |
| protein domain specific binding | KCNN2,ACSL3,MPP7,TNNI3,CEP68,SERPINB1A,SLC34A2,ODF1,HIST1H4D,YWHABA |
| voltage-gated calcium channel activity | NCS1,CACNG6,CACNG8,CACNG4,CACNB4B,CACNA2D4,CACNB2A,CACNA1C,CACNA1SB,RYR1 |
| contributes_to high voltage-gated calcium channel activity | CACNB4 |
| calcium channel regulator activity | PRKG1,GRM3,TSPAN13B,HPCAL4,TMEM110,STIM1B,CACNA2D3,SGK1,SGK2,CAV3 |
| protein binding | NR4A3,TRIM21,PAIP2,TEX19.1,RGS8,KIT,KRT6B,SEC23IP,ANXA9,SIGLEC8 |
| phosphoprotein binding | PITX2,GPRIN1,DPYS,CSNK1D,ARR3,FKBP4,DPYSL3,MTOR,SRC,TOX3 |
| protein kinase binding | SQSTM1,GSK3B,CAV2,CAMK2N1A,PRDX3,SNAP91,ZBTB4,HSPB1,CSPG4,SKI |
Interacting Protein
CACNB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNB2.
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