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CACNG3

  • Official Full Name

    calcium channel, voltage-dependent, gamma subunit 3

  • Overview

    The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for childhood absence epilepsy.
  • Synonyms

    CACNG3; calcium channel, voltage-dependent, gamma subunit 3; voltage-dependent calcium channel gamma-3 subunit; CACNG 3; Cacng2; Calcium channel voltage dependent gamma subunit 3; Neuronal voltage gated calcium channel gamma 3 subunit; Voltage dependent calcium channel gamma 3 subunit; Voltage gated calcium channel gamma subunit; TARP gamma-3; voltage-gated calcium channel gamma subunit; transmembrane AMPAR regulatory protein gamma-3; neuronal voltage-gated calcium channel gamma-3 subunit;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Chicken
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
  • Mouse
  • Mus musculus (Mouse)
  • Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CACNG3-0276H Recombinant Human CACNG3 Protein, GST-Tagged Wheat Germ GST
Human CACNG3-270HCL Recombinant Human CACNG3 cell lysate N/A
Mouse CACNG3-2625M Recombinant Mouse CACNG3 Protein Mammalian Cell His
Mouse CACNG3-1176M Recombinant Mouse CACNG3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CACNG3-1176M-B Recombinant Mouse CACNG3 Protein Pre-coupled Magnetic Beads HEK293
Rat CACNG3-1072R Recombinant Rat CACNG3 Protein Mammalian Cell His
Rat CACNG3-736R-B Recombinant Rat CACNG3 Protein Pre-coupled Magnetic Beads HEK293
Rat CACNG3-736R Recombinant Rat CACNG3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bos taurus (Bovine) RFL28810BF Recombinant Full Length Bovine Voltage-Dependent Calcium Channel Gamma-3 Subunit(Cacng3) Protein, His-Tagged E.coli expression system His Full Length (1-315)
Cynomolgus Monkey CACNG3-355C Recombinant Cynomolgus CACNG3 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey CACNG3-103C Recombinant Cynomolgus Monkey CACNG3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey CACNG3-103C-B Recombinant Cynomolgus Monkey CACNG3 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL23096HF Recombinant Full Length Human Voltage-Dependent Calcium Channel Gamma-3 Subunit(Cacng3) Protein, His-Tagged E.coli expression system His Full Length (1-315)
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) RFL36730MF Recombinant Full Length Macaca Fascicularis Voltage-Dependent Calcium Channel Gamma-3 Subunit(Cacng3) Protein, His-Tagged E.coli expression system His Full Length (1-315)
Mus musculus (Mouse) RFL3533MF Recombinant Full Length Mouse Voltage-Dependent Calcium Channel Gamma-3 Subunit(Cacng3) Protein, His-Tagged E.coli expression system His Full Length (1-315)
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) RFL26907PF Recombinant Full Length Pongo Abelii Voltage-Dependent Calcium Channel Gamma-3 Subunit(Cacng3) Protein, His-Tagged E.coli expression system His Full Length (1-315)
Rattus norvegicus (Rat) RFL17065RF Recombinant Full Length Rat Voltage-Dependent Calcium Channel Gamma-3 Subunit(Cacng3) Protein, His-Tagged E.coli expression system His Full Length (1-315)
Rhesus Macaque CACNG3-604R Recombinant Rhesus monkey CACNG3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CACNG3-432R-B Recombinant Rhesus Macaque CACNG3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CACNG3-432R Recombinant Rhesus Macaque CACNG3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken CACNG3-6227C Recombinant Chicken CACNG3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CACNG3 Related Articles

CACNG3 involved in several pathways and played different roles in them. We selected most pathways CACNG3 participated on our site, such as Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC), which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adrenergic signaling in cardiomyocytesPPP1R1A;PIK3CG;PLCB3;BCL2;SCN1BA;PIK3R3A;AKT3A;GNAS;MAPK14B
Arrhythmogenic right ventricular cardiomyopathyJUP;CDH2;CACNG3;CTNNA1;DES;DSC2;CTNNA2;DMD;DSP
Arrhythmogenic right ventricular cardiomyopathy (ARVC)CACNA2D4;LMNA;CACNG2;CACNB2;CACNA2D3;TCF7;ATP2A2;DSP;DMD
Cardiac muscle contractionVMHCL;CACNB4A;COX5B2;MYL4;ATP1B1B;CACNB2A;TNNT2;COX7A1;UQCR11
Developmental BiologyMARK3;LGI3;HELZ2;MYL12A;SCN4A;CFL1;MED18;MED15;TCF3A
Dilated cardiomyopathyTNNI3;CACNG1;CACNG3;TTN;ITGA3;IGF1;MYL3;DES;DAG1
Glutamate Binding, Activation of AMPA Receptors and Synaptic PlasticityHAND2;GRIP1;PICK1;NSFB;MYO6;AKAP5;CACNG2;NSFA;CACNG3
Hypertrophic cardiomyopathy (HCM)CACNG6;CACNB2;TGFB1;PRKAB2;PRKAA1;LMNA;ITGB7;ITGB5;SGCB

CACNG3 has several biochemical functions, for example, channel regulator activity, voltage-gated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNG3 itself. We selected most functions CACNG3 had, and list some proteins which have the same functions with CACNG3. You can find most of the proteins on our site.

Function Related Protein
channel regulator activityCNIH3;CACNG2A;SLC9A3R2;CACNG4;SNF8;CACNG8;CACNG2B;CACNG7;CACNG7A
voltage-gated calcium channel activityTPCN2;CACNG1;CACNA2D2;CACNG6;CACNA1SA;CACNA1DA;CALHM1;CACNB4A;CACNA2D1

CACNG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNG3.

Endoh, T; et al. Characterization of modulatory effects of postsynaptic metabotropic glutamate receptors on calcium currents in rat nucleus tractus solitarius. BRAIN RESEARCH 1024:212-224(2004).
Yamada, E; Endoh, T; et al. Angiotensin II-induced inhibition of calcium currents via G(q/11)-protein involving protein kinase C in hamster submandibular ganglion neurons. NEUROSCIENCE RESEARCH 43:179-189(2002).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
Have any post-translational modifications been identified on CACNG3? 01/20/2022

Techniques like mass spectrometry might reveal specific post-translational modifications on CACNG3.

How do genetic mutations in the CACNG3 gene influence its regulatory role? 03/13/2021

Genetic mutations in the CACNG3 gene can alter its regulatory function, impacting the dynamics and behavior of related calcium channels.

Are there specific proteins known to interact directly with CACNG3? 08/23/2020

CACNG3 primarily interacts with the alpha-1 subunit of calcium channels and may have associations with other channel proteins.

Which human tissues or cells predominantly express CACNG3? 06/05/2020

CACNG3 is mainly expressed in the brain, especially within neural tissues.

Are there any diseases or disorders directly linked to CACNG3 dysfunction? 03/14/2020

Dysfunctions or mutations in CACNG3 are implicated in certain neurological conditions, although deeper research is essential for concrete associations.

How does CACNG3 modulate the function of associated calcium channels? 06/29/2018

By binding to calcium channels, CACNG3 can influence the channel's gating dynamics, its localization, and the properties of calcium ion permeation.

What is the main biological role of CACNG3 in relation to calcium channels? 01/19/2018

CACNG3 serves as an auxiliary subunit, contributing to the modulation of the trafficking, activity, and surface expression of voltage-gated calcium channels.

Customer Reviews (3)

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Reviews
07/06/2022

    Precision in protein characterization, unmatched quality.

    05/17/2021

      Efficient protein quantification, a time and resource saver.

      01/28/2021

        Top-tier protein sequencing, a research game-changer.

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