CACNG3
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Official Full Name
calcium channel, voltage-dependent, gamma subunit 3
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Overview
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for childhood absence epilepsy. -
Synonyms
CACNG3; calcium channel, voltage-dependent, gamma subunit 3; voltage-dependent calcium channel gamma-3 subunit; CACNG 3; Cacng2; Calcium channel voltage dependent gamma subunit 3; Neuronal voltage gated calcium channel gamma 3 subunit; Voltage dependent calcium channel gamma 3 subunit; Voltage gated calcium channel gamma subunit; TARP gamma-3; voltage-gated calcium channel gamma subunit; transmembrane AMPAR regulatory protein gamma-3; neuronal voltage-gated calcium channel gamma-3 subunit;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Chicken
- Cynomolgus Monkey
- Homo sapiens (Human)
- Human
- Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
- Mouse
- Mus musculus (Mouse)
- Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- E.coli expression system
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- CACNG3 Related Articles
CACNG3 involved in several pathways and played different roles in them. We selected most pathways CACNG3 participated on our site, such as Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC), which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adrenergic signaling in cardiomyocytes | PPP1R1A;PIK3CG;PLCB3;BCL2;SCN1BA;PIK3R3A;AKT3A;GNAS;MAPK14B |
Arrhythmogenic right ventricular cardiomyopathy | JUP;CDH2;CACNG3;CTNNA1;DES;DSC2;CTNNA2;DMD;DSP |
Arrhythmogenic right ventricular cardiomyopathy (ARVC) | CACNA2D4;LMNA;CACNG2;CACNB2;CACNA2D3;TCF7;ATP2A2;DSP;DMD |
Cardiac muscle contraction | VMHCL;CACNB4A;COX5B2;MYL4;ATP1B1B;CACNB2A;TNNT2;COX7A1;UQCR11 |
Developmental Biology | MARK3;LGI3;HELZ2;MYL12A;SCN4A;CFL1;MED18;MED15;TCF3A |
Dilated cardiomyopathy | TNNI3;CACNG1;CACNG3;TTN;ITGA3;IGF1;MYL3;DES;DAG1 |
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity | HAND2;GRIP1;PICK1;NSFB;MYO6;AKAP5;CACNG2;NSFA;CACNG3 |
Hypertrophic cardiomyopathy (HCM) | CACNG6;CACNB2;TGFB1;PRKAB2;PRKAA1;LMNA;ITGB7;ITGB5;SGCB |
CACNG3 has several biochemical functions, for example, channel regulator activity, voltage-gated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNG3 itself. We selected most functions CACNG3 had, and list some proteins which have the same functions with CACNG3. You can find most of the proteins on our site.
Function | Related Protein |
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channel regulator activity | CNIH3;CACNG2A;SLC9A3R2;CACNG4;SNF8;CACNG8;CACNG2B;CACNG7;CACNG7A |
voltage-gated calcium channel activity | TPCN2;CACNG1;CACNA2D2;CACNG6;CACNA1SA;CACNA1DA;CALHM1;CACNB4A;CACNA2D1 |
CACNG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNG3.
- Q&As
- Reviews
Q&As (7)
Ask a questionTechniques like mass spectrometry might reveal specific post-translational modifications on CACNG3.
Genetic mutations in the CACNG3 gene can alter its regulatory function, impacting the dynamics and behavior of related calcium channels.
CACNG3 primarily interacts with the alpha-1 subunit of calcium channels and may have associations with other channel proteins.
CACNG3 is mainly expressed in the brain, especially within neural tissues.
Dysfunctions or mutations in CACNG3 are implicated in certain neurological conditions, although deeper research is essential for concrete associations.
By binding to calcium channels, CACNG3 can influence the channel's gating dynamics, its localization, and the properties of calcium ion permeation.
CACNG3 serves as an auxiliary subunit, contributing to the modulation of the trafficking, activity, and surface expression of voltage-gated calcium channels.
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