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Official Full Name chromobox homolog 5
Background This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Synonyms CBX5; chromobox homolog 5; HP1; HP1A; HEL25; chromobox protein homolog 5; HP1-ALPHA; HP1Hs alpha; antigen p25; HP1 alpha homolog; epididymis luminal protein 25; heterochromatin protein 1-alpha; heterochromatin protein 1 homolog alpha; chromobox homolog 5 (HP1 alpha homolog, Drosophila);
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CBX5-0483H Recombinant Human CBX5 Protein, GST-Tagged Wheat Germ GST
    Human CBX5-154H Recombinant Human CBX5 protein, T7/His-tagged E.coli T7/His
    Human CBX5-1781H Recombinant Human CBX5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CBX5-27763TH Recombinant Human CBX5, His-tagged E.coli His
    Human CBX5-32H Recombinant Human CBX5 Protein, MYC/DDK-tagged HEK293T Myc/DDK
    Human CBX5-3435H Recombinant Human CBX5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CBX5-7802HCL Recombinant Human CBX5 293 Cell Lysate HEK293 N/A
    Mouse CBX5-2795M Recombinant Mouse CBX5 Protein Mammalian Cell His
    Mouse Cbx5-794M Recombinant Mouse Cbx5 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rhesus Macaque CBX5-648R Recombinant Rhesus monkey CBX5 Protein, His-tagged Mammalian Cell His
    Zebrafish CBX5-5041Z Recombinant Zebrafish CBX5 Mammalian Cell His

    cbx5 involved in several pathways and played different roles in them. We selected most pathways cbx5 participated on our site, such as Aurora B signaling, E2F transcription factor network, Factors involved in megakaryocyte development and platelet production, which may be useful for your reference. Also, other proteins which involved in the same pathway with cbx5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Aurora B signaling TACC1; PEBP1; SGOL1; CDCA8; AURKC; NCAPD2; SEPT1; INCENP; CBX5; NDC80
    E2F transcription factor network E2F6; TRIM28; RBBP8; CES1; CES3; DHFR; CEBPA; HIC1; PRMT5; SMARCA2
    Factors involved in megakaryocyte development and platelet production HBBE3; MGC173646; HBD; DOCK9; IRF1B; MAFG; KIF2A; EHD1; KIF3C; KIF26A
    Hemostasis SERPINA1L; SLC16A8; WDR1; CALU; ITGB3A; CAP1; TRPC3; HBB-Y; SLC16A1; ANXA2

    cbx5 has several biochemical functions, for example, chromatin binding, histone deacetylase binding, methylated histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cbx5 itself. We selected most functions cbx5 had, and list some proteins which have the same functions with cbx5. You can find most of the proteins on our site.

    Function Related Protein
    chromatin binding HHEX; PCNA; CHAF1B; PPARG; EOMES; PHF13; ZGLP1; ZEB1; RNF168; DNMT1
    histone deacetylase binding NCOR2; PRDM1; YWHAE; MAPK8; RAD9A; ZNF703; RUNX2; CDC20; USF1; NKX3-1
    methylated histone binding RAG2; PHF2; L3MBTL2; CCDC101; FAM156A; TDRD3; CAPNS2; CBX5; RBBP5; TP53BP1
    protein binding SMURF2; ODF2; RFWD2; HSPA6; COPS7A; MAGOH; BRE; PELI1; WAS; DNAJC10
    protein binding, bridging FLRT1; ST13; SYNM; PPP2R3A; NUFIP1; FSCN2A; CAV2; CSTA; WWC1; NMD3
    protein homodimerization activity PRKG2; TERF2; ROPN1B; HSPB6; FIGF; FLT3; NTRK1; BCL2; STK4; NPR3
    repressing transcription factor binding HDAC7; TBP; HDAC7A; HHEX; TLE4; DDX20; SKI; TCF3; RUNX2; GMNN

    cbx5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cbx5 here. Most of them are supplied by our site. Hope this information will be useful for your research of cbx5.


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